Enhanced inflammatory activity of endometriotic lesions from the rectovaginal septum.

Endometriosis is characterised by the growth of ectopic lesions at multiple locations outside the uterine cavity and may be considered a collection of distinct but related conditions. The exact aetiology of endometriosis is still not clear although a role for inflammation is increasingly accepted. We therefore investigated the inflammatory activity of eutopic tissue and that of the matching ectopic lesions from different locations by measuring the genetic expression of inflammatory chemokines and cytokines. The gene expression in matching eutopic and ectopic tissue was compared, as was the gene expression in lesions from different locations. A significantly higher mRNA expression of the chemokines ENA-78 and RANTES and the cytokines IL-6 and TNF α was observed in endometriotic lesions of the rectovaginal septum (RVS) compared to that of matching eutopic tissue. Comparisons across lesion locations showed a significantly higher expression of IL-6 and TNF α in the RVS compared to lesions from either the ovaries or the peritoneum. These results show that the production of some inflammatory chemokines and cytokines is significantly increased in the ectopic endometrial tissue compared to matching eutopic tissue. Furthermore, IL-6 and TNF α are produced in significantly higher quantities in RVS lesions compared to other lesions.

Pugio fidei adversus Mauros, et Iudaeos : nunc primum in lucem editus

Raymundi Martini; cum observationibus Iosephi de Voisin

Primum et super omnium: nihil nocere Operationsindikation im Wandel bei Divertikulitis

Diverticulitis is a common disease in western countries and its incidence is increasing especially among young patients. Colonic diverticulosis, incidentally diagnosed by endoscopy or CT-scanning, has no immediate clinical consequences. Progression to diverticulitis develops in only 4 % of cases. In the last decades management of diverticular disease evolved and expectative treatment and less invasive techniques have gained importance. Elective resection has traditionally been advised after a second episode of diverticulitis or after a first episode if the patient was less than 50 years of age or complicated disease occurred. Recent changes in understanding the natural history of diverticular disease have substantially modified treatment paradigms. Elective resection in case of recurrent diverticular disease should be performed on a individual basis and in cases with complications like intestinal obstruction or fistulas. Primary anastomosis is an option even in emergency surgery due to colonic perforation, while diverting operations are indicated for selected patient groups with a high risk profile. Several prospective studies showed good results for laparoscopic drainage and lavage in the setting of perforated diverticulitis with generalized peritonitis, though this concept needs to be controlled with randomized clinical trials before application into the daily practice. This article should provide a short overview of trends in the surgical treatment of diverticulitis, help to understand the natural history of the disease and thereby explain the currently lower frequency of surgical interventions for diverticulitis.

Catena Scripturae : Tractatus Novus, In quo Ratio Accentuum, Quibus Hebraeus S. Scripturae contextus interpungitur, Nunc Primum Inventa luculentâ methodo accuratissimè exponitur

Opus ad interpretationem divinarum literarum inprimis necessarium, Autore M. Caspare Ledebuhrio, Coslino-Pomerano

Dictionum Hebraicarum, quae universo sefer tehilim continentur, Syllabus geminus : Quorum prior radices & quae inde formantur, cum singulorum interpretatione ... ordine alphabetico complectitur; In usum eorum, qui ad linguae sanctae studium primum accedunt, contextus

a Paulo Tossano

Adr. Tvrnebi Apologia Adversvs Qvorvndam Calvmnias, ad librum primum Ciceronis de Legibus

Auch als Beidr. zu: Turnèbe, Adrien: Lucubrationes variae

Ms. Barth. 75 (Ausst. 32) - In primum et secundum Sententiarum

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Fragm. lat. VIII 32 - Centiloquium cum expositione Hali Ibn Ridwan (Verbum primum - quartum)

Trägerband: Inc. oct. 361; Vorbesitzer: Dominikanerkloster Frankfurt am Main

Commentarius de Templo. Ex ejus libro, qui Schilte Haggibborim inscribitur excerptus, nunc primum a Blasio Ugolino Latina Interpretatione illustratus

Vorlage d. Digitalisats aus d. Besitz d. Theol. Hochschule St. Georgen

Ms. Praed. 23 - In primum Sententiarum Petri Lombardi

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Ms. Praed. 68 - Expositio in primum librum Canonis Avicennae

Vorbesitzer: Georg von Breidenbach; Dominikanerkloster Frankfurt am Main

Complectens accessiones er emendationes ad volumen primum totum, et partem secundi, quoad de scriptis anonymis exponit, pertinentes

fehlerhafte Seitenzählung: S. 215; 1025; 1087

Ms. Praed. 140 - Quaestiones in Sententiarum librum primum et secundum

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Calendarium Palaestinorum et universorum Judaeorum, ad annos quadraginta supputatum : nunc primum ex sermone Hebraeo in Latinum conversum ac scholiis

auctore rabbi Ori filio Simeonis judeo Palaestino. Illustratum per Jacobum Christmannum