School Leader Update, June 2007

Monthly newsletter produced by Iowa Department of Education

School Leader Update, July 2007

Monthly newsletter produced by Iowa Department of Education

School Leader Update, August 2007

Monthly newsletter produced by Iowa Department of Education

School Leader Update, September 2007

Monthly newsletter produced by Iowa Department of Education

School Leader Update, October 2007

Monthly newsletter produced by Iowa Department of Education

School Leader Update, November 2007

Monthly newsletter produced by Iowa Department of Education

Risk dominance selects the leader. An experimental analysis

Coordination games arise very often in studies of industrial organization and international trade. This type of games has multiple strict equilibria, and therefore the identification of testable predictions isvery difficult. We study a vertical product differentiation model with two asymmetric players choosing first qualities and then prices. This game has two equilibria for some parameter values. However, we apply the risk dominance criterion suggested by Harsanyi and Selten and show that it always selects the equilibrium where the leader is the firm having some initial advantage. We then perform an experimental analysis totest whether the risk dominance prediction is supported by the behaviour oflaboratory agents. We show that the probability that the risk dominance prediction is right depends crucially on the degree of asymmetry of the game. The stronger the asymmetries the higher the predictive power of the risk dominance criterion.

The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases.

The proteasome produces MHC class I-restricted antigenic peptides carrying N-terminal extensions, which are trimmed by other peptidases in the cytosol or within the endoplasmic reticulum. In this study, we show that the N-terminal editing of an antigenic peptide with a predicted low TAP affinity can occur in the cytosol. Using proteomics, we identified two cytosolic peptidases, tripeptidyl peptidase II and puromycin-sensitive aminopeptidase, that trimmed the N-terminal extensions of the precursors produced by the proteasome, and led to a transient enrichment of the final antigenic peptide. These peptidases acted either sequentially or redundantly, depending on the extension remaining at the N terminus of the peptides released from the proteasome. Inhibition of these peptidases abolished the CTL-mediated recognition of Ag-expressing cells. Although we observed some proteolytic activity in fractions enriched in endoplasmic reticulum, it could not compensate for the loss of tripeptidyl peptidase II/puromycin-sensitive aminopeptidase activities.

School Leader Update, February 2008

Monthly newsletter produced by Iowa Department of Education

School Leader Update, March 2008

Monthly newsletter produced by Iowa Department of Education

School Leader Update, April 2008

Monthly newsletter produced by Iowa Department of Education

School Leader Update, May 2008

Monthly newsletter produced by Iowa Department of Education

School Leader Update, June 2008

Monthly newsletter produced by Iowa Department of Education

School Leader Update, July 2008

Monthly newsletter produced by Iowa Department of Education