The development of UTCS/NETSIM/ICG: an integrated urban traffic control system - network simulation - interactive computer graphics program. Final report.

Transportation Department, Office of University Research, Washington, D.C.

Interactive simulation of the fate of hazardous chemicals during land treatment of oily wastes : RITZ user's guide /

Mode of access: Internet.

Development of an interactive system to study sub-lethal effects of pollutants on the behavior of organisms /

"Grant no. R803244."

Data base analyzer and parameter estimator (DBAPE) interactive computer program user's manual /

Mode of access: Internet.

A user's guide to ISRP : the Interactive Survey Reduction Program /

"November 1984."

Analytical modeling of driver response in crash avoidance maneuvering. Volume II: an interactive tire model for driver/vehicle simulation. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

OPTREG - an interactive computer program for optimization and regression. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Conceptual plan for an interactive highway safety design model. Final report.

Federal Highway Administration, Office of Safety and Traffic Operations Research and Development, McLean Va.

Biofuels impact on crop and food prices : using an interactive spreadsheet /

Mode of access: Internet.

Measurement of interactive computing : methodology and application /

Thesis--George Washington University.

A methodology for the selection of interactive computer services /

Includes bibliographical references (p. 39-42).

Application of measurement criteria in the selection of interactive computer services /

"Issued April 1980."

Summary of on-line or interactive physico-chemical numerical data systems /

"PB81-11551 1"

Distributed interactive simulation of combat.

Mode of access: Internet.

Interactive Effects of Morphine on HIV Infection: Role in HIV-Associated Neurocognitive Disorder

HIV epidemic continues to be a severe public health problem and concern within USA and across the globe with about 33 million people infected with HIV. The frequency of drug abuse among HIV infected patients is rapidly increasing and is another major issue since injection drug users are at a greater risk of developing HIV associated neurocognitive dysfunctions compared to non-drug users infected with HIV. Brain is a major target for many of the recreational drugs and HIV. Evidences suggest that opiate drug abuse is a risk factor in HIV infection, neural dysfunction and progression to AIDS. The information available on the role of morphine as a cofactor in the neuropathogenesis of HIV is scanty. This review summarizes the results that help in understanding the role of morphine use in HIV infection and neural dysfunction. Studies show that morphine enhances HIV-1 infection by suppressing IL-8, downregulating chemokines with reciprocal upregulation of HIV coreceptors. Morphine also activates MAPK signaling and downregulates cAMP response element-binding protein (CREB). Better understanding on the role of morphine in HIV infection and mechanisms through which morphine mediates its effects may help in devising novel therapeutic strategies against HIV-1 infection in opiate using HIV-infected population.