Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.

There is increasing evidence for an important role of adverse early experience on the development of major psychiatric disorders in adulthood. Corticotropin-releasing factor (CRF), an endogenous neuropeptide, is the primary physiological regulator of the mammalian stress response. Grown nonhuman primates who were exposed as infants to adverse early rearing conditions were studied to determine if long-term alterations of CRF neuronal systems had occurred following the early stressor. In comparison to monkeys reared by mothers foraging under predictable conditions, infant monkeys raised by mothers foraging under unpredictable conditions exhibited persistently elevated cerebrospinal fluid (CSF) concentrations of CRF. Because hyperactivity of CRF-releasing neurons has been implicated in the pathophysiology of certain human affective and anxiety disorders, the present finding provides a potential neurobiological mechanism by which early-life stressors may contribute to adult psychopathology.

Effects of suspended solids and sediment on reproduction and early life of warmwater fishes : a review /

Mode of access: Internet.

Life and times of Frederick Douglass : written by himself ; his early life as a slave, his escape from bondage, and his complete history to the present time /

Mode of access: Internet.

William Penn's early life in brief, 1644-1674,

"Edition strictly limited to 300 copies, numbered and signed by the author."

Early life of Eamonn de Valera,

Mode of access: Internet.

The family and early life of Stonewall Jackson /

Includes bibliographical references (p. 196-202) and index.

The early life, campaigns, and public services of Robert E. Lee; with a record of the campaigns and heroic deeds of his companions in arms ...

Added t.p. vignette: The conflagration of Richmond.

The early life of Jesus and new light on Passion Week /

Includes index.

Shelley's early life from original sources. With curious incidents, letters, and writings, now first published or collected.

Mode of access: Internet.

Early life and public career of Hon. James G. Blaine.

Mode of access: Internet.

Extracts from a manuscript left by the late Mary Reckitt of Woodbridge / containing remarks on her religious progress from early life; with an acclount of her experiences and exercises of mind during her last illness : to which is added a short account of her mother.

Smith II : 476.

Pictures of early life, or, Sketches of youth /

Mode of access: Internet.

The welcome visitor, or, The good uncle : being a collection of original stories, containing several well-authenticated anecdotes, displaying striking traits of virtue and heroism in early life.

Copy in Dept. of Rare Books and Special Collections bound in old marbled boards and dark red leather spine. Blue speckled page edges. Inscribed on front endpaper: "Gilbert Elliot from his sisters on his birthday Feb. 23, 1835."

Memoir of the early life of William Cowper, Esq /

"Dissuasives against self-murder."--p. 171-173.