La dénervation rénale unilatérale et le système kallikréine-bradykinine rénal chez le rat [Unilateral renal denervation and the renal kallikrein-bradykinin system in the rat].

AIM: The antihypertensive effect of renal denervation in hypertensive patients is partially explained by increased tubular natriuresis. To study the possible contribution of the kallikrein-kinin system (KKS) to this natriuretic effect in rats, we measured kallikrein activity (KA) and bradykinin concentrations (BK) in plasma and tissues. METHODS: To measure KA, we adapted and validated an enzymatic assay that cleaves para-nitroaniline (pNA) from the tripeptide H-D-Pro-Phe-Arg-pNA. The coefficients of variation (CV) within- and between-assays were less than 8% for plasma and tissue KA (plasma n=6 and 13; tissue n=4). Linear results for serially diluted samples confirmed the assay specificity. Tissue BK determinations were based on an established assay for plasma BK: tissue was homogenized and kinins extracted in ethanol, and BK was isolated by high-performance (HPLC) liquid chromatography and quantitated by radioimmunassay. Within- and between-assay CV for plasma BK were 18% (n=8 and n=35, respectively) and for BK in various tissues less than 16% (n=5-8). RESULTS: In male Wistar rats (n=3), plasma BK was 8.2±6.6 fmol/mL (mean±SD), and tissue BK (fmol/g) in 14 tested organs varied between brain (14±3) and submaxillary gland (521±315). Six days after left-sided unilateral renal denervation, left renal tissue BK (89±9) was not different from right renal BK (75±23). Similarly, KA was comparable in the two kidneys (left 18.0±1.5, right 15.8±1.4μkat/g). CONCLUSION: Any possible effect of unilateral renal denervation on the kidney's KKS would have to be bilateral.

Higher education and national identity : Polish student activism in Russia 1832-1863

Doctoral dissertation, University of Helsinki

Suomen valkoinen sotilasarkkitehtuuri 1926-1939

Summary: "White" military architecture in Finland, 1926-1939

Keskustajääkäri Aarne Sihvo : näkökulma aseellisen voiman ja yhteiskunnan vuorovaikutukseen itsenäistymisen murroksesta paasikiviläiseen toiseen tasavaltaan

Summary: Middle-of-the-roader : General Aarne Sihvo (1889-1963) and the interaction between the Finnish armed forces and democracy

Yksissä leivissä : ruokolahtelainen perhelaitos ja yhteisöllinen toiminta 1750-1850

Summary: Together as one : extended families and collective labour in Ruokolahti, 1750-1850

Vanhan Suomen lahjoitusmaat 1710-1826

English summary: Noble Land-Holding and Serfdom in "Old Finland"

Kaikki irti metsästä : metsän käyttö ja muutos taigan reunalla itäisimmässä Suomessa erätaloudesta vuoteen 2000

Summary: Capitalizing on the forest : use, users and change in the forest in the wilderness economy on the edge of the taiga in Eastern Finland through the year 2000

Arkkitehdit, sota ja yhdyskuntasuhteiden hallinta : Alvar Aallon Kokemäenjokilaakson aluesuunnitelma tilansäätelyprojektina

Summary: Architects, war, and the governance of socio-spatial relationships in localities : a study of Alvar Aalto's Kokemäenjoki River Valley regional plan as a project of the regulation of space

Talonpoikainen etiikka ja kulutuksen henki : kotitalousneuvonnasta kuluttajapolitiikkaan 1900-luvun Suomessa

Summary: Peasant ethic and the spirit of consumption : from household advising to consumer policy in the 20th century Finland

Korkeakoulutuksen kasvu, lohkoutuminen ja eriarvoisuus Suomessa

Summary: Growth, fragmentation and inequality in higher education in Finland

The discourse on political pluralism in early eighteenth-century England : a conceptual study with special reference to terminology of religious origin

Doctoral dissertation, University of Jyväskylä

Kruunun taloudenpito Hämeen linnassa 1500-luvun puolivälissä

Summary: Financial management at Häme Castle in the mid-sixteenth century (from 1539 to about 1570)

Taistelu kouludemokratiasta : kouludemokratian aalto Suomessa

Summary: The fight for school democracy in Finland

Suuresta suvusta pieneen perheeseen : itäsuomalainen perhe 1700-luvulla

Summary: From joint family to nuclear family