Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape.

Malignant melanoma accounts for most of the increasing mortality from skin cancer. Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand (FasL). In metastatic lesions, Fas-expressing T cell infiltrates were proximal to FasL+ tumor cells. In vitro, apoptosis of Fas-sensitive target cells occurred upon incubation with melanoma tumor cells; and in vivo, injection of FasL+ mouse melanoma cells in mice led to rapid tumor formation. In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors.

Les Avantages que les femmes peuvent recevoir de la philosophie, et principalement de la morale . Ou L'abrégé de cette science . Par Loüis de Lesclache.

Mécénat texte imprimé : Cet ouvrage a été numérisé grâce à Edouard Fernandez-Bollo

Recueil de règlements des métiers et corporations de Paris, connu sous le nom de Livre des métiers, d'Étienne BOILEAU.

Publié par G.-B. Depping et R. de Lespinasse (Paris, 1837 et 1879, in-4°). — Dans ce manuscrit la « tierce partie » du Livre des métiers est formée par la copie de divers privilèges et de diverses chartes : « Privilege de l'Université de Paris », mars 1302 (n. s.) (fol. 133) ; — « Privilege de Teroanne », 1190 (fol. 134 v°) ; — « Lettre de la confrarie de Nostre Dame et de Saint Jaques », mars 1319 (n. s.) (fol. 134 v°) ; — « Lettres de Saint-Germain des Prez », février 1273 (n. s.), août 1275, etc. (fol. 135) ; — « Copies de plusieurs chartes de Philippe-Auguste et de Philippe le Bel (fol. 137) ; — « Le cri pour les monnoies » (fol. 139 v°), etc. ; — « Ce sont les estatus de la geole du Chastellet de Paris signifiées... par mestre Richart de Gisors » (fol. 144) ; — « Ce sont toutes les aumosnes qui sont faites par la main de l'aumosnier monseigneur le roy de France » (fol. 147) ; — « Modus solvendi in thesauro », 1298-1335 (fol. 160) ; — Tables comparatives de la valeur des monnaies et barèmes divers (fol. 162). — Aux fol. 1 et 172, le nom d'un ancien possesseur : « Jehan Le Feron. »

Reliure de : Les oeuvres de François Villon

Numérisation partielle de reliure

Les dix premiers livres de l'Iliade d'Homère prince des poetes : Traduictz en vers Francois, par M. Hugues Salel, de la chambre du Roy, & Abbé de S. Cheron

[Iliade (français). Extrait. 1545]

Les dix premiers livres de l'Iliade d'Homère prince des poetes : Traduictz en vers Francois, par M. Hugues Salel, de la chambre du Roy, & Abbé de S. Cheron

[Iliade (français). Extrait. 1545]

Iowa Driver’s License Renewal, August 3, 2007

One-on-one communication with driver’s license customers is the most valuable tool Driver Services employees use to help drivers stay independent and safe. Driver Services employees understand that a sense of remaining independent, in everything from running errands to shopping to visits with friends, family and doctors, depends on a driver’s license. There are times when Driver Services personnel, or even the drivers themselves, determine it’s time to stop driving. In those cases, people are given a free identification card. There are also times when the DOT must suspend a person’s driving privilege. This can be caused by vision problems, a medical condition or unsafe driving. If the driver cannot be relicensed, DOT personnel make the commitment to work with the individual by providing information about available transportation alternatives. We are providing this information to make the renewal process understandable and less stressful. We hope that by explaining why the DOT screens vision, requires medical information and requests drive tests, and describing how these all relate to highway safety, drivers will know what to expect. Personnel are available to answer questions or discuss concerns at any of the Iowa Department of Transportation or County Treasurer driver’s license sites. Please contact one of the driver’s license stations listed in this booklet.

Vaccination des requérants d'asile dans le canton de Vaud [Vaccination of asylum seekers in the canton Vaud, Switzerland].

Even if only a small proportion of asylum seekers obtains a permanent resident permit, a significant number of them stay for a prolonged or indefinite period in Switzerland in a legal or illegal way. The asylum seekers can be either vectors or victims of infectious diseases. Some of these diseases can be prevented by vaccination. This article summarizes the recent decisions which have been taken in the canton Vaud concerning the vaccination of asylum seekers. These new recommendations privilege a large coverage of a maximum number of asylum seekers. Vaccinations against varicella and human papillomavirus will be proposed in addition to the already previously recommended vaccines. Finally the medical visits for the vaccinations will also be an opportunity to screen for chronic hepatitis B which has been neglected until now.