Review : "Spatial planning and climate change" by Elizabeth Wilson and Jake Piper

This timely and thorough book seeks to provide evidence-based assessments of ways in which spatial planning may develop and deliver new strategies for addressing both the causes and impacts of climate change. The authors state that much of the analysis is informed by experiences and learning from their own involvements with climate change projects. The book aims to be relevant to a wide audience and nominates its intended readership to include planning practitioners, scholars, post-graduate students of built environment courses, politicians and the ‘interested’ public. In this regard, the authors skilfully deliver with a comprehensive and accessible dissemination of the nexus between spatial planning and climate change...

Computer-assisted measurements of coronal knee joint laxity in vitro are related to low-stress behavior rather than structural properties of the collateral ligaments

The relationship between coronal knee laxity and the restraining properties of the collateral ligaments remains unknown. This study investigated correlations between the structural properties of the collateral ligaments and stress angles used in computer-assisted total knee arthroplasty (TKA), measured with an optically based navigation system. Ten fresh-frozen cadaveric knees (mean age: 81 ± 11 years) were dissected to leave the menisci, cruciate ligaments, posterior joint capsule and collateral ligaments. The resected femur and tibia were rigidly secured within a test system which permitted kinematic registration of the knee using a commercially available image-free navigation system. Frontal plane knee alignment and varus-valgus stress angles were acquired. The force applied during varus-valgus testing was quantified. Medial and lateral bone-collateral ligament-bone specimens were then prepared, mounted within a uni-axial materials testing machine, and extended to failure. Force and displacement data were used to calculate the principal structural properties of the ligaments. The mean varus laxity was 4 ± 1° and the mean valgus laxity was 4 ± 2°. The corresponding mean manual force applied was 10 ± 3 N and 11 ± 4 N, respectively. While measures of knee laxity were independent of the ultimate tensile strength and stiffness of the collateral ligaments, there was a significant correlation between the force applied during stress testing and the instantaneous stiffness of the medial (r = 0.91, p = 0.001) and lateral (r = 0.68, p = 0.04) collateral ligaments. These findings suggest that clinicians may perceive a rate of change of ligament stiffness as the end-point during assessment of collateral knee laxity.

Cungellela by William ‘Dura Danje’ Leisha and Shem ‘Curan Danje’ Leisha

Research background: Cungelela is an intercultural music project undertaken in collaboration with William ‘Dura Danje’ Leisha and Shem ‘Curan Danje’ Leisha. The project contributes to cultural maintenance for Australian First Nations peoples, and is informed by prior work in this area by scholars including Peter Dunbar-Hall, Chris Gibson and Karl Neuenfeldt. These existing studies have discussed the complexities of intercultural collaboration, and the types of cultural politics that are involved when Indigenous and non-Indigenous musicians and scholars work together on projects of cultural significance. Critical race theory has also informed the creative work, as a means of interpreting the implicit and explicit discourses of race that arise through intercultural creative practice. The project asked the research question, in what ways can collaborative music making contribute to intercultural understanding and support cultural maintenance for Australian First Nations people affected by the Stolen Generations? Research contribution: This project has identified that collaborative production of recorded popular music can produce shared affective, embodied and transformative forms of knowledge about the impact of the Stolen Generations on Australian First Nations peoples. Research significance: The compact disc was presented by Aunty Anne Leisha as part of an invited presentation at the World Indigenous Nations Higher Education Consortium in New Mexico, 2013. The work also formed part of a refereed conference presentation at the 2013 conference of the International Association for the Study of Popular Music held at the University of Oviedo, Gijon, Spain.

Prevalence and predictors of advance directives in Australia

Background Advance care planning is regarded as integral to better patient outcomes yet little is known about the prevalence of advance directives in Australia. Aims To determine the prevalence of advance directives (ADs) in the Australian population. Methods A national telephone survey about estate and advance planning. Sample was stratified by age (18-45 and >45 years) and quota sampling occurred based on population size in each State and Territory. Results Fourteen percent of the Australian population has an AD. There is State variation with people from South Australia and Queensland more likely to have an AD than people from other states. Will making and particularly completion of a financial enduring power of attorney are associated with higher rates of AD completion. Standard demographic variables were of limited use in predicting whether a person would have an AD. Conclusions Despite efforts to improve uptake of advance care planning (including ADs), barriers remain. One likely trigger for completing an AD and advance care planning is undertaking a wider future planning process (e.g. making a will or financial enduring power of attorney). This presents opportunities to increase advance care planning but steps are needed to ensure that planning which occurs outside the health system is sufficiently informed and supported by health information so that it is useful in the clinical setting. Variations by State could also suggest that redesign of regulatory frameworks (such as a user-friendly and well publicised form backed by statute) may help improve uptake of ADs.

5-year Chlamydia vaccination programme could reverse disease-related koala population decline: Predictions from a mathematical model using field data

BACKGROUND Many koala populations around Australia are in serious decline, with a substantial component of this decline in some Southeast Queensland populations attributed to the impact of Chlamydia. A Chlamydia vaccine for koalas is in development and has shown promise in early trials. This study contributes to implementation preparedness by simulating vaccination strategies designed to reverse population decline and by identifying which age and sex category it would be most effective to target. METHODS We used field data to inform the development and parameterisation of an individual-based stochastic simulation model of a koala population endemic with Chlamydia. The model took into account transmission, morbidity and mortality caused by Chlamydia infections. We calibrated the model to characteristics of typical Southeast Queensland koala populations. As there is uncertainty about the effectiveness of the vaccine in real-world settings, a variety of potential vaccine efficacies, half-lives and dosing schedules were simulated. RESULTS Assuming other threats remain constant, it is expected that current population declines could be reversed in around 5-6 years if female koalas aged 1-2 years are targeted, average vaccine protective efficacy is 75%, and vaccine coverage is around 10% per year. At lower vaccine efficacies the immunological effects of boosting become important: at 45% vaccine efficacy population decline is predicted to reverse in 6 years under optimistic boosting assumptions but in 9 years under pessimistic boosting assumptions. Terminating a successful vaccination programme at 5 years would lead to a rise in Chlamydia prevalence towards pre-vaccination levels. CONCLUSION For a range of vaccine efficacy levels it is projected that population decline due to endemic Chlamydia can be reversed under realistic dosing schedules, potentially in just 5 years. However, a vaccination programme might need to continue indefinitely in order to maintain Chlamydia prevalence at a sufficiently low level for population growth to continue.

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10−8). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10−4, Bonferroni corrected), of which six reached P < 5 × 10−8, including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.

William James, Sciences of Mind, and Anti-imperial Discourse

In the past few decades, the humanities and social sciences have developed new methods of reorienting their conceptual frameworks in a “world without frontiers.” In this book, Bernadette M. Baker offers an innovative approach to rethinking sciences of mind as they formed at the turn of the twentieth century, via the concerns that have emerged at the turn of the twenty-first. The less-visited texts of Harvard philosopher and psychologist William James provide a window into contemporary debates over principles of toleration, anti-imperial discourse, and the nature of ethics. Baker revisits Jamesian approaches to the formation of scientific objects including the child mind, exceptional mental states, and the ghost to explore the possibilities and limits of social scientific thought dedicated to mind development and discipline formation around the construct of the West.

Ei sanat salahan joua : fennistiikan murteenkeruun historiaa 1868 - 1925

Pro gradu -tutkielmani käsittelee Suomen murteiden sanakirjan taustaksi kerätyn Suomen murteiden sana-arkiston kartuttamisen historiaa; fennistisen murteenkeruun alkuvaiheita. Lähestyn murresanakirjan pitkää hanketta tutkimus- ja kulttuurihistoriallisesta näkökulmasta. Kansankielen sanakirja on fennistiikan merkittävimpiä tutkimushankkeita. Suo-men kielen vanhojen pitäjänmurteiden sanasto on ällistyttävän laaja aineisto, jonka keräämiseen ja julkaisemiseen on kulunut toista vuosisataa, ja sanakirjan toimitustyö jatkuu edelleen. Kansanmurteemme sisältävät paitsi kielitieteellisesti mielenkiintoista aineistoa myöskin runsaasti tietoa agraarisen elinkeinorakenteen aikakaudelta. Dialektologia ja kansatiede kulkevat käsikkäin. Murresanakirja on niin ollen merkittävä kansallinen omaisuus, jonka arvo koko suomalaiselle yhteiskunnalle on eittämättä suuri. Murteiden sanakirjan syntysanat on ajoitettavissa vuoteen 1868, vaikka toki fennistiikassa oli leksikografisia pyrintöjä jo ennen sitä (mm. Lönnrotin Suomalais-ruotsalainen sanakirja). Sanakirjahankkeessa on hahmotettavissa kolme vaihetta, joita kutsun ryhdistäytymisiksi. Nämä tapahtuivat noin vuosina 1896, 1916 ja 1925. Valotan työni aluksi hieman kansallisten tieteiden ja 1800-luvun alun aatehistoriallista taustaa (luku 2), jonka jälkeen tutkin murresanakirjahankkeen alkuvaiheita ja ensimmäisten sanastonkeruiden käynnistymistä (luku 3). Käsittelen kutakin hankkeen organisatorista muutosvaihetta ja hallinnollisten puitteiden kehittymistä luvuissa 4-6. Lopuksi pohdin murresanakirjan ja murteenkeruun historiallista merkitystä fennistiikalle ja yhteiskunnalle (luku 7). Tutkimukseni lähteinä on oppihistoriallista kirjallisuutta sekä murteiden keruusta vastanneiden yhteisöjen asiakirjoja. Erityisen kiinnostaviksi osoittautuivat Kotimaisten kielten tutkimuskeskuksessa säilytettävät sanakirjahankkeen hallinnolliset asiakirjat 1916-1925. Tuon esiin varhaisempiakin pöytäkirjamainintoja. Hankkeen alussa Suomalaisen Kirjallisuuden Seuran Kielitieteellinen Osakunta ja Kotikielen Seura keräsivät ensimmäisiä sanastokokoelmia. Tämän jälkeen ensimmäinen ryhdistäytyminen tapahtui vuodesta 1896 lähtien, jolloin Suomalaisen Kirjallisuuden Seura otti vastuun hankkeesta, E. N. Setälän tunnettua sanakirjaohjelmaa ja E. A. Ekmanin Suomen kielen keräilysanastoa noudattaen. Keruu oli kuitenkin liian hidasta, joten 1916 perustettiin Suomen kielen sanakirjaosakeyhtiö, jotta toimintaan saataisiin enemmän varoja. Ensimmäinen maailmansota ja sisällissota kuitenkin romahduttivat rahan arvon, ja kolmannen kerran hanke jouduttiin organisoimaan uudelleen vuonna 1925, Sanakirjasäätiön muodossa. Vuonna 1976 Sanakirjasäätiö liittyi Kotimaisten kielten tutkimuskeskukseen. Kansanmurteiden keräämisessä korostuu kaikissa keruun vaiheissa kaksi asiaa. Ensinnäkin sanastuksella oli aina kiire. Vanhat murteet olivat katoamassa, ja ne piti saada nopeasti talteen. Tähän kiinnitettiin huomiota jo varhain, ja vielä 1900-luvun loppupuoliskollakin, kun keruuhanke hiljalleen saatiin loppuunviedyksi. Toiseksi sanakirjahanke on aina joutunut elämään kädestä suuhun, toisin sanoen taloudelliset puitteet ovat sanelleet keruumahdollisuudet. Vakaalle taloudelliselle pohjalle hanke pääsi vasta 1930-luvulla Sanakirjasäätiön aikana, jolloin siihen alettiin saada valtion rahoitusta. Murresanakirjahankkeen läpi kulkee punaisena lankana kansallisromanttinen innostus ja isänmaallis-tieteellinen pyrkimys suomen kirjakielen kehittämiseen, joka vielä 1800-luvun puolivälissä oli meneillään. Kansalliset tieteet lujittivat itsenäistymistä ja suoma-laistumista. Aatehistorian kautta sanakirjahanke asettuu laajempaan yhteyteen. Avainsanat: tutkimushistoria, suomen kielen murteet, murteenkeruu, dialektologia, suomen murteiden sanakirja, fennistiikan oppihistoria, leksikografia, kansalliset tieteet, Suomalaisen Kirjallisuuden Seura, Kotikielen Seura, Suomen kielen sanakirjaosakeyhtiö, Sanakirjasäätiö

In Defence of "the Lesser Cousin of History": An Interview with Rohan Wilson

Few branches of postcolonial literature are as contested as the historical fiction of settler societies. This interview with the Australian historical novelist Rohan Wilson, author of The Roving Party (2011) and To Name Those Lost (2014), explores the intersections between truth, accuracy, and existential authenticity in his fictional accounts of nineteenth-century Tasmania. Wilson offers a nuanced yet robust defence of fiction’s role in narrating colonial history. He explains his intentions in writing two linked yet distinctive novels of the frontier—one that focuses on the “Black War” of the 1820s and 1830s, and another that explores how racial violence is refracted by capitalism in subsequent decades.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

FTO genotype is associated with phenotypic variability of body mass index

There is evidence across several species for genetic control of phenotypic variation of complex traits1, 2, 3, 4, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using ~170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype)5, 6, 7, is also associated with phenotypic variability. We show that the results are not due to scale effects or other artefacts, and find no other experiment-wise significant evidence for effects on variability, either at loci other than FTO for BMI or at any locus for height. The difference in variance for BMI among individuals with opposite homozygous genotypes at the FTO locus is approximately 7%, corresponding to a difference of ~0.5 kilograms in the standard deviation of weight. Our results indicate that genetic variants can be discovered that are associated with variability, and that between-person variability in obesity can partly be explained by the genotype at the FTO locus. The results are consistent with reported FTO by environment interactions for BMI8, possibly mediated by DNA methylation9, 10. Our BMI results for other SNPs and our height results for all SNPs suggest that most genetic variants, including those that influence mean height or mean BMI, are not associated with phenotypic variance, or that their effects on variability are too small to detect even with samples sizes greater than 100,000.

Group portrait at the farewell banquet for Dr. William Antopol from the laboratory staff of Mount Sinai Hospital; Ken's Chop House, New York city Portraits Groups

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Portrait of William and Charlotte Engel Levison Portraits Couples

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