Bulletin populaire, revue générale, technique et pratique, de la pisciculture et des améliorations de la pêche

"Bibliographie aquicole par R. de Drouin de Bouville", in each number of new series (except no. 6)

Congress of arts and science, Universal exposition, St. Louis, 1904;

"Special works of reference" (accompanying particularly Professor Boltzmann's address)": v. 1, p. [625]-626.

De pactionum inter graecas civitates factarum ad belium pacemque pertinentium appellationibus, formulis, ratione /

Detached from Dissertationes philologicae haleses, v. 7.

Brief sketch of the life and labors of Rev. Alexander Bettis;

Mode of access: Internet.

Wet en adat; bladen gewijd in het algemeen aan het recht en aanverwante onderwerpen, in het bizonder aan Indische rechtsbelangen.

Mode of access: Internet.

El Jardín de Falerina, Francisco de Rojas Zorrilla, Antonio Coello Ochoa y Pedro Calderón de la Barca. Edición, introducción y notas de Felipe B. Pedraza Jiménez y Rafael González Cañal, (Barcelona: Octaedro, 2010)

Parece mentira que una pieza teatral firmada por Calderón de la Barca haya tardado más de tres cientos años en aparecer impresa y que sea ahora,en el 2010, cuando lo haga por primera vez. ¿A qué se debe esta falta de interés por la obra?La respuestanos la ofrecen Felipe B. Pedza Jiménez y Rafael González Cañal en el capítulo que abre el estudio preliminar de su edicion tulado«Razones de una sin razón»

Some descriptions of the battles in which the commands of Gen. John B. Sanborn, of St. Paul, Minnesota, participated in the departments of Tennessee and Missouri during the rebellion of 1861-65.

Mode of access: Internet.

Novyi︠a︡ stikhotvorenīi︠a︡ F.B. Millera : 1861-1873.

Mode of access: Internet.

Roswell B. Taylor, a 1861, Law 1865

see Taylor letter RE his student days in

Second Lieutenant William B. McCreery, July 21, 1861 (date of battle), On reverse: First Battle of Bull Run on the battlefield, Description: three soldiers under tree with swords drawn

Scene showing a group of men, women, and children. The men appear to be members of the Grand Army of the Republic, possibly the Gov. Crapo Post #145

Life and letters of Sir James Graham, second baronet of Netherby, P. C., G. C. B., 1792-1861,

Mode of access: Internet.

An Asp49 Phospholipase A2 From Snake Venom Induces Cyclooxygenase-2 Expression And Prostaglandin E2 Production Via Activation Of Nf-κb, P38mapk, And Pkc In Macrophages.

Phospholipases A2 (PLA2) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2). Herein, we explored the molecular mechanisms and signaling pathways leading to these MT-III-induced effects. Results demonstrated that MT-III induced activation of the transcription factor NF-κB in isolated macrophages. By using NF-κB selective inhibitors, the involvement of this factor in MT-III-induced COX-2 expression and PGE2 production was demonstrated. Moreover, MT-III-induced COX-2 protein expression and PGE2 release were attenuated by pretreatment of macrophages with SB202190, and Ly294002, and H-7-dihydro compounds, indicating the involvement of p38MAPK, PI3K, and PKC pathways, respectively. Consistent with this, MT-III triggered early phosphorylation of p38MAPK, PI3K, and PKC. Furthermore, SB202190, H-7-dihydro, but not Ly294002 treatment, abrogated activation of NF-κB induced by MT-III. Altogether, these results show for the first time that the induction of COX-2 protein expression and PGE2 release, which occur via NF-κB activation induced by the sPLA2-MT-III in macrophages, are modulated by p38MAPK and PKC, but not by PI3K signaling proteins.

Sulfonyl-hydrazones of cyclic imides derivatives as potent inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB)

Searching lead compounds for new antituberculosis drugs, the activity of synthetic sulfonamides and sulfonyl-hydrazones were assayed for their potential inhibitory activity towards a protein tyrosine phosphatase from Mycobacterium tuberculosis - PtpB. Four sulfonyl-hydrazones N-phenylmaleimide derivatives were active (compounds 14, 15, 19 and 21), and the inhibition of PtpB was found to be competitive with respect to the substrate p-nitrophenyl phosphate. Structure-based molecular docking simulations were performed and indicated that the new inhibitor candidates showed similar binding modes, filling the hydrophobic pocket of the protein by the establishment of van der Waals contacts, thereby contributing significantly to the complex stability.

Acute and chronic effects of exercise on inflammatory markers and B-type natriuretic peptide in patients with coronary artery disease

Few studies have prospectively addressed the effects of exercise in the inflammatory activity of patients with coronary artery disease (CAD). We sought to evaluate the consequences of an acute bout of exercise on inflammatory markers and BNP in untrained CAD patients before and after randomization to a training program. 34 CAD patients underwent a 50-min acute exercise session on a cycle-ergometer at 65% peak oxygen uptake before and after blood sampling. They were then randomized to a 4-month chronic exercise program (15 patients) or general lifestyle recommendations (19 patients), undergoing a new acute session of exercise after that. In the overall population, acute exercise caused a significant increase in C-reactive protein [CRP; 1.79 (4.49) vs. 1.94 (4.89) mg/L, P < 0.001], monokine induced by interferon-gamma [Mig; 351 (324) vs. 373 (330) pg/mL, P = 0.027] and vascular adhesion molecule-1 [VCAM-1; 226 (82) vs. 252 (110) pg/mL, P = 0.02]. After 4-months, in exercise-trained patients, there was a significant decrease in the inflammatory response provoked by the acute exercise compared to patients in the control group reflected by a significant decrease in the differences between rest and post-exercise levels of CRP [-0.29 (0.84) mg/L vs. -0.11 (0.21) mg/L, P = 0.05]. Resting BNP was also significantly lower in exercise-trained patients when compared to untrained controls [15.6 (16.2) vs. 9.7 (11.4) pg/mL, P = 0.04 and 19.2 (27.8) vs. 23.2 (27.5) pg/mL, P = 0.76; respectively]. Chronic exercise training might partially reverse the inflammatory response caused by acute exercise in CAD patients. These results suggest that regular exercise is an important nonpharmacological strategy to the improvement in inflammation in CAD patients.