A finite element-spherical harmonics model for radiative transfer in inhomogeneous clouds. Part II. some applications

EVENT has been used to examine the effects of 3D cloud structure, distribution, and inhomogeneity on the scattering of visible solar radiation and the resulting 3D radiation field. Large eddy simulation and aircraft measurements are used to create realistic cloud fields which are continuous or broken with smooth or uneven tops. The values, patterns and variance in the resulting downwelling and upwelling radiation from incident visible solar radiation at different angles are then examined and compared to measurements. The results from EVENT confirm that 3D cloud structure is important in determining the visible radiation field, and that these results are strongly influenced by the solar zenith angle. The results match those from other models using visible solar radiation, and are supported by aircraft measurements of visible radiation, providing confidence in the new model.

Clouds, aerosols, and precipitation in the marine boundary layer: an ARM Mobile Facility Deployment

The Clouds, Aerosol, and Precipitation in the Marine Boundary Layer (CAP-MBL) deployment at Graciosa Island in the Azores generated a 21-month (April 2009–December 2010) comprehensive dataset documenting clouds, aerosols, and precipitation using the Atmospheric Radiation Measurement Program (ARM) Mobile Facility (AMF). The scientific aim of the deployment is to gain improved understanding of the interactions of clouds, aerosols, and precipitation in the marine boundary layer. Graciosa Island straddles the boundary between the subtropics and midlatitudes in the northeast Atlantic Ocean and consequently experiences a great diversity of meteorological and cloudiness conditions. Low clouds are the dominant cloud type, with stratocumulus and cumulus occurring regularly. Approximately half of all clouds contained precipitation detectable as radar echoes below the cloud base. Radar and satellite observations show that clouds with tops from 1 to 11 km contribute more or less equally to surface-measured precipitation at Graciosa. A wide range of aerosol conditions was sampled during the deployment consistent with the diversity of sources as indicated by back-trajectory analysis. Preliminary findings suggest important two-way interactions between aerosols and clouds at Graciosa, with aerosols affecting light precipitation and cloud radiative properties while being controlled in part by precipitation scavenging. The data from Graciosa are being compared with short-range forecasts made with a variety of models. A pilot analysis with two climate and two weather forecast models shows that they reproduce the observed time-varying vertical structure of lower-tropospheric cloud fairly well but the cloud-nucleating aerosol concentrations less well. The Graciosa site has been chosen to be a permanent fixed ARM site that became operational in October 2013.

Large contribution of supercooled liquid clouds to the solar radiation budget of the Southern Ocean

The Southern Ocean is a critical region for global climate, yet large cloud and solar radiation biases over the Southern Ocean are a long-standing problem in climate models and are poorly understood, leading to biases in simulated sea surface temperatures. This study shows that supercooled liquid clouds are central to understanding and simulating the Southern Ocean environment. A combination of satellite observational data and detailed radiative transfer calculations is used to quantify the impact of cloud phase and cloud vertical structure on the reflected solar radiation in the Southern Hemisphere summer. It is found that clouds with supercooled liquid tops dominate the population of liquid clouds. The observations show that clouds with supercooled liquid tops contribute between 27% and 38% to the total reflected solar radiation between 40° and 70°S, and climate models are found to poorly simulate these clouds. The results quantify the importance of supercooled liquid clouds in the Southern Ocean environment and highlight the need to improve understanding of the physical processes that control these clouds in order to improve their simulation in numerical models. This is not only important for improving the simulation of present-day climate and climate variability, but also relevant for increasing confidence in climate feedback processes and future climate projections.

Design of novel antituberculosis compounds using graph-theoretical and substructural approaches

The increasing resistance of Mycobacterium tuberculosis to the existing drugs has alarmed the worldwide scientific community. In an attempt to overcome this problem, two models for the design and prediction of new antituberculosis agents were obtained. The first used a mixed approach, containing descriptors based on fragments and the topological substructural molecular design approach (TOPS-MODE) descriptors. The other model used a combination of two-dimensional (2D) and three-dimensional (3D) descriptors. A data set of 167 compounds with great structural variability, 72 of them antituberculosis agents and 95 compounds belonging to other pharmaceutical categories, was analyzed. The first model showed sensitivity, specificity, and accuracy values above 80% and the second one showed values higher than 75% for these statistical indices. Subsequently, 12 structures of imidazoles not included in this study were designed, taking into account the two models. In both cases accuracy was 100%, showing that the methodology in silico developed by us is promising for the rational design of antituberculosis drugs.

Långa toppar - metod för uttag av skogsbränsle i slutavverkningar : Slutrapport (STEM-projekt 21937-1)

SammanfattningHögskolan Dalarna har i samarbete med Skogsägarna Mellanskog, Naturbränsle i Mellan¬sverige AB och GDE-Net genomfört studier på en ny metod för uttag av skogsbränsle från slutavverkningar. Metoden går ut på att timmer tas ut som enda rundvirkessortiment. Resten av trädet, samt klenare träd som inte håller timmerdimension, tas ut som ett bränslesortiment. Metoden har jämförts med en konventionell slutavverkning med uttag av timmer, massaved och GROT-flis.Enligt genomförda försök skulle en avverkning enligt den nya metoden (långa toppar) ge ett högre drivningsnetto och drygt dubbelt så mycket bränsleflis som en konventionell avverk¬ning. En anledning till det högre drivningsnettot är att kostnaden för flisning blir lägre än vid flisning av GROT och att flisen betalas bättre än GROT-flis. Resultaten är beroende av de faktiska beståndsförutsättningarna och gällande prisrelationer mellan massaved och bränsle¬flis.Faktorer som har en positiv inverkan på drivningsnettot vid uttag av ”långa toppar” är t.ex. stora uttagsvolymer och korta terrängtransportavstånd samt bestånd med en hög andel virke av låg kvalitet eller udda sortiment som betalas dåligt på rundvirkesmarknaden.SummaryIn Sweden forest energy from final felling is traditionally harvested as logging residues after harvesting of timber (saw logs) and pulpwood, but depending on the market situation other methods with higher yield of forest energy might be of interest. Dalarna University has study a new method called “Undelimbed long tops” where only saw timber was taken out as an industrial assortment. The rest of the trees and smaller trees that don’t hold timber dimensions was left intact on the clear-felled area and been chipped later on. The study was done in different stands with some different conditions. The results have been compared with the traditional method for final felling. The surplus (forest owners net income) was higher in almost all stands when the method with “undelimbed long tops” was used, compared to the traditional method for taking out forest energy, and the volume of chips was more than doubled. A reason for the higher income from long tops is that the costs for chipping is lower and the prize of chips is higher compared to chips from logging residues. Other reason is that forest owners will not be paid for wasted pulpwood, but will be fully paid for the chips from such pulpwood. Factors that will have a positive influence on the ULT-method are for example large logging volumes and short distance between the logging area and the landing, different kinds of price reductions on pulpwood and large volumes of rotten wood or low paid industrial assortments.

Changes in fibre curvature during the processing of wool and alpaca fibres and their blends

This paper studied the wool and alpaca fibre curvature and its variation during the fibre processing. It revealed the effect of wool fibre crimp on the cohesion properties of alpaca and wool blended slivers. Different wool and alpaca tops were blended via a number of gillings, and the role of wool fibre curvature in alpaca/wool blend processing has also been investigated. During the wool fibre processing, fibre curvature tended to diminish gradually from scoured fibre to top. Blending wool with alpaca fibres improved the cohesion properties of the blended sliver, compared with pure alpaca slivers. For a high ratio of alpaca component in the blend, a high-crimp wool should be used to achieve good sliver cohesion.

Eri silk fibre attributes and sliver preparation

Eri silk produced by Philosamia cynthia ricini silkworm is a fibre not well-known to the silk industry, in spite of the fact that Eri silk is finer, softer, and has better mechanical and thermal properties than most animal fibres. Eri silk has a high commercial potential, as the host plants of Eri silk worms are widespread in diverse geographical locations, and the worms also have a higher degree of disease resistance than most other silk worms. Mills are often not aware of the properties of Eri for designing appropriate end products. Thus, Eri silk yarn is traditionally produced by hand spinning, and Eri silk usually ends up as material for handwoven shawls. The potential for bulk fibre processing and the development of soft luxurious novel Eri silk products is yet to be discovered. To better understand the material and its processing behaviour, Eri silk was characterised and cocoons were processed into tops through degumming, opening, and cutting filaments into different lengths, followed by a worsted spun silk processing route. Fibre properties such as fineness, crimp, strength and length at different processing stages up to combed tops were measured. The results indicate that staple Eri silk can be processed via the worsted topmaking route, using a cut length of 200 mm or 150 mm for filament sheets prepared from degummed cocoons.

Targeting hepatitis B virus and human papillomavirus induced carcinogenesis : novel patented therapeutics

Viral infections leading to carcinogenesis tops the risk factors list for the development of human cancer. The decades of research has provided ample scientific evidence that directly links 10-15% of the worldwide incidence of human cancers to the infections with seven human viruses. Moreover, the insights gained into the molecular pathogenetic and immune mechanisms of hepatitis B virus (HBV) and human papillomavirus (HPV) viral transmission to tumour progression, and the identification of their viral surface antigens as well as oncoproteins have provided the scientific community with opportunities to target these virus infections through the development of prophylactic vaccines and antiviral therapeutics. The preventive vaccination programmes targeting HBV and high risk HPV infections, linked to hepatocellular carcinoma (HCC) and cervical cancer respectively have been recently reported to alter age-old cancer patterns on an international scale. In this review, with an emphasis on HBV and HPV mediated carcinogenesis because of the similarities and differences in their global incidence patterns, viral transmission, mortality, molecular pathogenesis and prevention, we focus on the development of recently identified HBV and HPV targeting innovative strategies resulting in several patents and patent applications.

Weathering, fibre strength and colour properties of processed white cashmere

Weathering refers to the degradation of wool fibres that occur during growth from exposure of the fleece to sunlight, water and air. Weathering damage to Merino wool reduces quantities of fibre that are harvested, reduces length in both raw and processed wools, reduces spinning performance and dyeing outcomes. This work aimed to aimed to quantify if and to what extent weathering occurred in 38 lots of commercial dehaired white cashmere and cashmere top sourced from traditional and new origins of production and the extent of any association between weathering and tensile strength properties of the dehaired cashmere and cashmere top. The cashmere was tested for physical properties, bundle tenacity and extension, tristimulus values brightness (Y) and yellowness (Y-Z) and reflectance. Dye uptake was used as an index of weathering. Linear models, relating to weathering, bundle tenacity and Y-Z were fitted to origin and other objective measurements. Mean attributes (range) were: mean fibre diameter, 17.0 μm (13.5–21.3 μm); bundle tenacity of tops, 10.3 cN/tex (8.3–12.9 cN/tex), for dehaired fibre, 10.1 cN/tex (9.1–11.4 cN/tex). Stain uptake varied from 0.92 to 6.34 mg/g fibre indicating a six-fold variation in the extent of weathering. Both the extent of weathering and the bundle tenacity of commercial lots of cashmere were affected by the origin of the cashmere. Increased weathering reduced bundle tenacity, bundle extension, increased the yellowness and reduced reflectance of white cashmere. Bundle tenacity of cashmere declined as fibre diameter variability increased from 20 to 22.5%. For the samples tested, the cashmere from China, Mongolia, Afghanistan and Iran showed more weathering than cashmere from Australia, New Zealand and the USA. The differences in the extent of weathering and of bundle tenacity between cashmere from different origins were of commercial significance.

Viable approaches for increasing the efficiency of buiding integrated photovoltaic systems

Nowadays, there is growing interest towards the area of building integrated photovoltaic (BIPV) systems and PV microgrids (MGs) in the field of power generation and distribution systems. This is mainly due to the higher adaptability and compatibility of these systems with preplanned sustainable development strategies in the most urban areas. The quiet operating process and movement free characteristic of photovoltaic systems brought them to the roof tops of the buildings in urban and rural areas and made them the most demanded means of renewable energy systems. This study highlights the problems affecting the performance and efficiency of BIPV systems and presents miscellaneous solutions and recommendations to solve these problems.

Estimativa da precipitação através de técnicas de sensoriamento remoto : estudo de caso para o estado do Rio Grande do Sul

A quantificação da precipitação é dificultada pela extrema aleatoriedade do fenômeno na natureza. Os métodos convencionais para mensuração da precipitação atuam no sentido de espacializar a precipitação mensurada pontualmente em postos pluviométricos para toda a área de interesse e, desta forma, uma rede com elevado número de postos bem distribuídos em toda a área de interesse é necessária para um resultado satisfatório. No entanto, é notória a escassez de postos pluviométricos e a má distribuição espacial dos poucos existentes, não somente no Brasil, mas em vastas áreas do globo. Neste contexto, as estimativas da precipitação com técnicas de sensoriamento remoto e geoprocessamento pretendem potencializar a utilização dos postos pluviométricos existentes através de uma espacialização baseada em critérios físicos. Além disto, o sensoriamento remoto é a ferramenta mais capaz para gerar estimativas de precipitação nos oceanos e nas vastas áreas continentais desprovidas de qualquer tipo de informação pluviométrica. Neste trabalho investigou-se o emprego de técnicas de sensoriamento remoto e geoprocessamento para estimativas de precipitação no sul do Brasil. Três algoritmos computadorizados foram testados, sendo utilizadas as imagens dos canais 1, 3 e 4 (visível, vapor d’água e infravermelho) do satélite GOES 8 (Geostacionary Operational Environmental Satellite – 8) fornecidas pelo Centro de Previsão de Tempo e Estudos Climáticos do Instituto Nacional de Pesquisas Espaciais. A área de estudo compreendeu todo o estado do Rio Grande do Sul, onde se utilizaram os dados pluviométricos diários derivados de 142 postos no ano de 1998. Os algoritmos citados buscam identificar as nuvens precipitáveis para construir modelos estatísticos que correlacionem as precipitações diária e decendial observadas em solo com determinadas características físicas das nuvens acumuladas durante o mesmo período de tempo e na mesma posição geográfica de cada pluviômetro considerado. Os critérios de decisão que norteiam os algoritmos foram baseados na temperatura do topo das nuvens (através do infravermelho termal), reflectância no canal visível, características de vizinhança e no plano de temperatura x gradiente de temperatura Os resultados obtidos pelos modelos estatísticos são expressos na forma de mapas de precipitação por intervalo de tempo que podem ser comparados com mapas de precipitação obtidas por meios convencionais.

Novas tecnologias e inovação organizacional: estudos de caso para analisar a relevância da variável confiança nos processos de implementação de tecnologia em um hospital privado

A implementação crescente de novas tecnologias em todos os setores da economia aumentou o grau de complexidade e incerteza organizacional e, como resultado, fez emergir novos desafios para as empresas e seus membros. Para que se possa compreender as novas tecnologias, seu potencial inovador e seus efeitos sob as variáveis organizacionais é preciso revisar os conceitos tradicionais da Teoria das Organizações e propor novas abordagens que contemplem aspectos do contexto social. O presente trabalho analisa quatro (4) casos de implementação de novas tecnologias em uma instituição hospitalar privada de grande porte na cidade de São Paulo. Foram estudadas as tecnologias de produção e distribuição de medicamentos e materiais, tratamento de radioterapia, diangóstico por imagem e palm tops. A pesquisa de campo serviu-se de uma metodologia qualitativa e indutiva. O levantamento de dados deu-se através dos métodos de entrevistas semi-estruturadas com profissionais que estiveram envolvidos ou foram afetados pelas novas tecnologias, além de observação passiva e análise de documentos. O principal objetivo do trabalho foi verificar se o aumento da complexidade organizacional, oriundo do emprego crescente de novas tecnologias, é acompanhado por uma redefinição das relações de confiança na instituição hospitalar. Adicionalmente, pretendeu-se investigar o papel da confiança como variável social de adaptação das organizações às exigências do meio ambiente.

Umbelliferone induces changes in the structure and pharmacological activities of Bn IV, a phospholipase A(2) isoform isolated from Bothrops neuwiedi

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