Untersuchung der Kernstruktur von 3 He mittels Polarisationsobservablen

Durch die Möglichkeit, gleichzeitig mehrere Polarisationsfreiheitsgradernin der quasi-elastischen Elektronstreuung an $^3mathrm{He}$ zurnmessen, bietet sich ein neuer experimenteller Zugang zu kleinen, aber rnwichtigen Partialwellenbeiträgen ($S'$, $D$-Welle) desrn$^3mathrm{He}$-Grundzustands. Dies ermöglicht nicht nur ein tieferesrnVerständnis des Drei-Körper-Systems, sondern bietet auch diernMöglichkeit, Erkenntnisse über die $^3mathrm{He}$-Struktur undrnDynamik zu erlangen. Mit Hilfe dieser Informationen lassen sich abrninitio Rechnungen testen, sowie Korrekturen berechnen, die für anderernExperimente (z.B. Messung von $G_{en}$) benötigt werden. rnrnModerne Faddeev-Rechnungen liefern nicht nur eine quantitativernBeschreibung des $^3mathrm{He}$-Grundzustands, sondern geben auchrneinen Einblick in die sogenannten spinabhängigenrnImpulsverteilungen. Eine gründliche experimentelle Untersuchung ist in rndiesem Zusammenhang nötig, um eine solide Basis für die Üperprüfungrnder theoretische Modelle zu liefern. EinrnDreifach-Polarisationsexperiment liefert hier zum einen wichtigernDaten, zum anderen kann damit untersucht werden, ob mit der Methoderndes glqq Deuteron-Tagginggrqq polarisiertes $^3mathrm{He}$ alsrneffektives polarisiertes Protonentarget verwendet werden kann. rnrnDas hier vorgestellte Experiment kombiniert erstmals Strahl- undrnTargetpolarisation sowie die Messung der Polarisation des auslaufendenrnProtons. Das Experiment wurde im Sommer 2007 an derrnDrei-Spektrometer-Anlage der A1-Kollaboration an MAMI rndurchgeführt. Dabei wurde mit einer Strahlenergie vonrn$E=855,mathrm{MeV}$ bei $q^2=-0,14,(mathrm{GeV/c})^2$rn$(omega=0,13,mathrm{GeV}$, $q=0,4,mathrm{GeV/c})$ gemessen.rnrnDie bestimmten Wirkungsquerschnitte, sowie die Strahl-Target- und diernDreifach-Asymmetrie werden mit theoretischen Modellrechnungen vonrnJ. Golak (Plane Wave Impuls Approximation PWIA, sowie ein Modell mitrnEndzustandswechselwirkung) verglichen. Zudem wurde das Modell von dernForest verwendet, welches den Wirkungsquerschnitt über eine gemessenernSpektralfunktion berechnet. Der Vergleich mit den Modellrechnungenrnzeigt, dass sowohl der Wirkungsquerschnitt, als auch die Doppel- undrnDreifach-Asymmetrie gut mit den theoretischen Rechnungenrnübereinstimmen. rnrnDie Ergebnisse dieser Arbeit bestätigen, dass polarisiertesrn$^3mathrm{He}$ nicht nur als polarisiertes Neutronentarget, sondernrndurch Nachweis des Deuterons ebenfalls als polarisiertesrnProtonentarget verwendet werden kann.

Hadronic matrix elements in lattice QCD

The lattice formulation of Quantum ChromoDynamics (QCD) has become a reliable tool providing an ab initio calculation of low-energy quantities. Despite numerous successes, systematic uncertainties, such as discretisation effects, finite-size effects, and contaminations from excited states, are inherent in any lattice calculation. Simulations with controlled systematic uncertainties and close to the physical pion mass have become state-of-the-art. We present such a calculation for various hadronic matrix elements using non-perturbatively O(a)-improved Wilson fermions with two dynamical light quark flavours. The main topics covered in this thesis are the axial charge of the nucleon, the electro-magnetic form factors of the nucleon, and the leading hadronic contributions to the anomalous magnetic moment of the muon. Lattice simulations typically tend to underestimate the axial charge of the nucleon by 5 − 10%. We show that including excited state contaminations using the summed operator insertion method leads to agreement with the experimentally determined value. Further studies of systematic uncertainties reveal only small discretisation effects. For the electro-magnetic form factors of the nucleon, we see a similar contamination from excited states as for the axial charge. The electro-magnetic radii, extracted from a dipole fit to the momentum dependence of the form factors, show no indication of finite-size or cutoff effects. If we include excited states using the summed operator insertion method, we achieve better agreement with the radii from phenomenology. The anomalous magnetic moment of the muon can be measured and predicted to very high precision. The theoretical prediction of the anomalous magnetic moment receives contribution from strong, weak, and electro-magnetic interactions, where the hadronic contributions dominate the uncertainties. A persistent 3σ tension between the experimental determination and the theoretical calculation is found, which is considered to be an indication for physics beyond the Standard Model. We present a calculation of the connected part of the hadronic vacuum polarisation using lattice QCD. Partially twisted boundary conditions lead to a significant improvement of the vacuum polarisation in the region of small momentum transfer, which is crucial in the extraction of the hadronic vacuum polarisation.

Parity violating asymmetry in the electron deuteron quasielastic scattering, strange vector and axial vector form factors and beam normal spin asymmetries

In dieser Arbeit wurde die paritätsverletzende Asymmetrie in derrnquasielastischen Elektron-Deuteron-Streuung bei Q^2=0.23 (GeV/c)^2 mitrneinem longitudinal polarisierten Elektronstrahl bei einer Energie von 315rnMeV bestimmt. Die Messung erfolgte unter Rückwärtswinkeln. Der Detektor überdeckte einen polaren Streuwinkelbereichrnzwischen 140 und 150 deg. Das Target bestand aus flüssigemrnDeuterium in einer Targetzelle mit einer Länge von 23.4 cm. Dierngemessene paritätsverletzende Asymmetrie beträgt A_{PV}^d = (-20.11 pm 0.87_{stat} pm 1.03_{syst}), wobei der erste Fehler den statistischenrnFehlereitrag und der zweite den systematischen Fehlerbeitrag beschreibt. Ausrnder Kombination dieser Messung mit Messungen der paritätsverletzendenrnAsymmetrie in der elastischen Elektron-Proton-Streuung bei gleichem Q^2rnsowohl bei Vorwärts- als auch bei Rückwärtsmessungen können diernVektor-Strange-Formfaktoren sowie der effektive isovektorielle und isoskalarernVektorstrom des Protons, der die elektroschwachen radiativen Anapolkorrekturenrnenthält, bestimmt werden. Diese Arbeit umfasst ausserdem die Bestimmungrnder Asymmetrien bei einem transversal polarisierten Elektronstrahl sowohl beirneinem Proton- als auch einem Deuterontarget unter Rückwärtswinkeln beirnImpulsüberträgen von Q^2=0.10 (GeV/c)^2, Q^2=0.23 (GeV/c)^2rnund Q^2=0.35 (GeV/c)^2. Die im Experiment beobachteten Asymmetrien werdenrnmit theoretischen Berechnungen verglichen, welche den Imaginärteil der Zweiphoton-Austauschamplitude beinhalten.

IN-SITU TEM PLASMA CHIP NANOFABRICATION AND CHARACTERIZATION

A silicon-based microcell was fabricated with the potential for use in in-situ transmission electron microscopy (TEM) of materials under plasma processing. The microcell consisted of 50 nm-thick film of silicon nitride observation window with 60μm distance between two electrodes. E-beam scattering Mont Carlo simulation showed that the silicon nitride thin film would have very low scattering effect on TEM primary electron beam accelerated at 200 keV. Only 4.7% of primary electrons were scattered by silicon nitride thin film and the Ar gas (60 μm thick at 1 atm pressure) filling the space between silicon nitride films. Theoretical calculation also showed low absorption of high-energy e-beam electrons. Because the plasma cell needs to survive the high vacuum TEM chamber while holding 1 atm internal pressure, a finite element analysis was performed to find the maximum stress the low-stress silicon nitride thin film experienced under pressure. Considering the maximum burst stress of low-stress silicon nitride thin film, the simulation results showed that the 50 nm silicon nitride thin film can be used in TEM under 1 atm pressure as the observation window. Ex-situ plasma generation experiment demonstrated that air plasma can be ignited at DC voltage of 570. A Scanning electron microscopy (SEM) analysis showed that etching and deposition occurred during the plasma process and larger dendrites formed on the positive electrode.

MEASUREMENT OF TUMOR BLOOD FLOW FOLLOWING NEUTRON IRRADIATION (ACTIVATION)

Clinical oncologists and cancer researchers benefit from information on the vascularization or non-vascularization of solid tumors because of blood flow's influence on three popular treatment types: hyperthermia therapy, radiotherapy, and chemotherapy. The objective of this research is the development of a clinically useful tumor blood flow measurement technique. The designed technique is sensitive, has good spatial resolution, in non-invasive and presents no risk to the patient beyond his usual treatment (measurements will be subsequent only to normal patient treatment).^ Tumor blood flow was determined by measuring the washout of positron emitting isotopes created through neutron therapy treatment. In order to do this, several technical and scientific questions were addressed first. These questions were: (1) What isotopes are created in tumor tissue when it is irradiated in a neutron therapy beam and how much of each isotope is expected? (2) What are the chemical states of the isotopes that are potentially useful for blood flow measurements and will those chemical states allow these or other isotopes to be washed out of the tumor? (3) How should isotope washout by blood flow be modeled in order to most effectively use the data? These questions have been answered through both theoretical calculation and measurement.^ The first question was answered through the measurement of macroscopic cross sections for the predominant nuclear reactions in the body. These results correlate well with an independent mathematical prediction of tissue activation and measurements of mouse spleen neutron activation. The second question was addressed by performing cell suspension and protein precipitation techniques on neutron activated mouse spleens. The third and final question was answered by using first physical principles to develop a model mimicking the blood flow system and measurement technique.^ In a final set of experiments, the above were applied to flow models and animals. The ultimate aim of this project is to apply its methodology to neutron therapy patients. ^

On the fine structure of oxygen distribution in surface water layers in the area between Iceland and Faroe Islands

During the international "Overflow-Expedition'' 1973 on R.V. "Meteor" oxygen concentrations in surface layers were measured in order to determine the oxygen gradients within the first two meters and to add some informations to the mechanisms of oxygen exchange at the air-sea interface. These investigations may be interesting also with regard to longterm- observations of the oxygen distribution in the Atlantic, especially the problem of the A.O.U. (apparent oxygen utilization) determination. To measure oxygen gradients a special sampler was built which is able to take water samples each 20 cm of the first 2 meters. These data were supplemented by further samples down to 150 m, taken by conventional water samplers, from which samples were also taken to measure N2/O2-relations. By comparing these relations with theoretical relations in air-saturated water the influence of biological production and consumption on the oxygen contents in water could be estimated. A simple glass apparatus was built to extract gas from the water samples, and hereafter the N2/O2-relations were determined by mass spectrometry. Most distributions of the oxygen anomaly show a negative oxygen balance which varies largely, probably due to strong mixing processes in the Iceland-Faroe ridge area. The distribution of surface oxygen saturation values are of two different types. The values of the stations 260, 262 and 270 stem from mixed water and show homogeneous supersaturations, as can be found instantly when whitecaps appear. The values of 9 other stations are from water, sampled during calm periods which has been mixed and supersaturated before. They show a decreasing oxygen saturation towards the sea surface and often undersaturation in the upper decimeters up to 98 % and even 91 %. So at the air-sea interface even less initial oxygen saturation than 100 % can be found after supersaturation during heavy weather periods.

Diseño de laboratorio para la evaluación de silenciadores "in situ"

Se ha realizado el diseño de un sistema que permite realizar ensayos de silenciadores “in situ”. Para evaluar el comportamiento del sistema de ensayo de silenciadores se procede a caracterizar los paneles acústicos que son la base del sistema. De los paneles empleados en el sistema, se determinará por diferencia del nivel de presión sonora, el aislamiento a ruido aéreo de los mismos, partiendo del promedio de las medidas obtenidas en la sala emisora de la cámara reverberante con el material instalado y en la sala receptora. Se realizan distintas medidas de los niveles de presión sonora en sala emisora de la cámara reverberante y en la receptora así como del tiempo de reverberación con los paneles instalados en el hueco existente en el elemento de separación vertical de la cámara. Una vez ensayados los paneles, se ha procedido a medir los niveles de presión sonora que se obtienen antes y después de la interposición de distintos silenciadores en el sistema diseñado con el propósito de disponer de un laboratorio de medida de la atenuación de silenciadores. Para ello, se procede a efectuar el montaje, en la puerta sencilla de la cámara reverberante, de los componentes del sistema diseñado y se realizan mediciones de la atenuación que proporciona la colocación de un silenciador en el sistema y su posterior sustitución por un conducto. La medición de la atenuación del nivel de presión sonora que producen los distintos silenciadores se realiza por pérdidas por inserción, siguiendo las directrices de la Norma UNE-ISO 11820 y por el método de conductos forrados como cálculo teórico. ABSTRACT. A system has been designed for testing silencers “in situ”. In first place, to evaluate the behavior of the system in the test of silencers, it has been proceeded to customize the acoustic panels that are the basis of the system. The attenuation sound of the panels used in the system will be determined by the difference of sound pressure level. It will be made through the average of the measurements obtained in the source room of the reverberant chamber, the average of the measurements obtained in the receiving room, as well as the reverberation time, with the material installed in the hole of the walls. Once the panels are tested, and with the purpose of having a laboratory to measure the attenuation of silencers, the sound pressure levels has been measured before and after inserting the different silencers in the designed system. To obtain these measures, the components of the system designed have been installed in the hollow of the single door of the reverberant chamber and then the sound pressure level has been measured with a silencers first and after with a duct instead of the silencer. The measurement of the attenuation of the sound pressure level produced by different silencers has been made by insertion loss, following the 11820 UNE-ISO, as well as theoretical calculation has been made by the method of duct lined.

Extended surface fluidized bed heat transfer

Experirnental data and theoretical calculation on the heat transfer performance of extended surface submerged: in shallow air fluidized beds ~ less than 150 mm, are presented. Energy t;ransferrence from the bed material was effected by water cooled tubes passing through the fins. The extended surface tested was either manufactured from square or radial copper fins silver soldered to a circular basic tube or commercially supplied, being of the crimped or extruded helical fin type. Performances are compared, for a wide range of geometric variables, bed configurations and fluidized materials, with plain and oval tubes operating under similar experimental conditions. A statistical analysis of all results, using a regression technique, has shown the relative importance of each significant variable. The bed to surface heat transfer coefficients are higher than those reported in earlier published work using finned tubes in much deeper beds and the heat transfer to the whole of the extended surface is at least as good as that previously reported for un-finned tubes. The improved performance is attributed partly to the absence of large bubbles in shallow beds and it is suggested that the improved circulation of the solids when constrained in the narrow passages between adjacent fins may be a contributory factor. Flow visualisation studies between a perspex extended surface and a fluidized bed using air at ambient temperatures, have demonstrated the effect of too small a fin spacing. Fin material and the bonding to the basic tube are more important in the optimisation of performance than in conventional convective applications because of the very much larger heat fluxes involved. A theoretical model of heat flow for a radial fin surface, provides data concerning the maximum heat transfer and minimum metal required to fulfil a given heat exchange duty. Results plotted in a series of charts aim at assisting the designer of shalJow fluidized beds.

Some aspects of the dynamic performance of machine tool structural joints

The work presented in this thesis is concerned with the dynamic behaviour of structural joints which are both loaded, and excited, normal to the joint interface. Since the forces on joints are transmitted through their interface, the surface texture of joints was carefully examined. A computerised surface measuring system was developed and computer programs were written. Surface flatness was functionally defined, measured and quantised into a form suitable for the theoretical calculation of the joint stiffness. Dynamic stiffness and damping were measured at various preloads for a range of joints with different surface textures. Dry clean and lubricated joints were tested and the results indicated an increase in damping for the lubricated joints of between 30 to 100 times. A theoretical model for the computation of the stiffness of dry clean joints was built. The model is based on the theory that the elastic recovery of joints is due to the recovery of the material behind the loaded asperities. It takes into account, in a quantitative manner, the flatness deviations present on the surfaces of the joint. The theoretical results were found to be in good agreement with those measured experimentally. It was also found that theoretical assessment of the joint stiffness could be carried out using a different model based on the recovery of loaded asperities into a spherical form. Stepwise procedures are given in order to design a joint having a particular stiffness. A theoretical model for the loss factor of dry clean joints was built. The theoretical results are in reasonable agreement with those experimentally measured. The theoretical models for the stiffness and loss factor were employed to evaluate the second natural frequency of the test rig. The results are in good agreement with the experimentally measured natural frequencies.

Ocular motor triad with single vision contact lenses compared to spectacle lenses

Aim: Theoretically myopes are required to exert more accommodation and vergence when wearing single vision contact lenses compared to glasses and hypermetropes less. This study aims to quantify the effects clinically. Method: Thirty subjects (21 female, nine male, average age 21.0 ± 2.2 years) with a range of refractive errors (-7.87 D to +3.50 D) viewed in a random order, static targets at 0.1, 0.5, 1.0, 2.0, 3.0, 4.0 and 5.0 D accommodative demand that were matched for angular subtense. The subjects were fully corrected with spectacles and daily disposable contact lenses to their full prescription. Accommodation was monitored objectively with the PowerRefractor and Shin-Nippon SRW5000 and vergence and pupil size with the PowerRefractor. Results: Myopes exerted greater accommodative effort for viewing near targets with contact lenses than glasses and hypermetropes less (r2 = 0.35, p = 0.001 PowerRefractor). Myopes also exerted greater vergence effort for viewing near targets with contact lenses than glasses and hypermetropes less (r2 = 0.22, p < 0.01). Conclusion: Theoretical calculation of the accommodative and vergence requirements with glasses compared to contact lenses reflect clinical findings, although there is reasonable variability between individuals. © 2006 British Contact Lens Association.

The effect of digital image resolution and compression on anterior eye imaging

Aim: To determine the theoretical and clinical minimum image pixel resolution and maximum compression appropriate for anterior eye image storage. Methods: Clinical images of the bulbar conjunctiva, palpebral conjunctiva, and corneal staining were taken at the maximum resolution of Nikon:CoolPix990 (2048 × 1360 pixels), DVC:1312C (1280 × 811), and JAI:CV-S3200 (767 × 569) single chip cameras and the JVC:KYF58 (767 × 569) three chip camera. The images were stored in TIFF format and further copies created with reduced resolution or compressed. The images were then ranked for clarity on a 15 inch monitor (resolution 1280 × 1024) by 20 optometrists and analysed by objective image analysis grading. Theoretical calculation of the resolution necessary to detect the smallest objects of clinical interest was also conducted. Results: Theoretical calculation suggested that the minimum resolution should be ≥579 horizontal pixels at 25 × magnification. Image quality was perceived subjectively as being reduced when the pixel resolution was lower than 767 × 569 (p<0.005) or the image was compressed as a BMP or <50% quality JPEG (p<0.005). Objective image analysis techniques were less susceptible to changes in image quality, particularly when using colour extraction techniques. Conclusion: It is appropriate to store anterior eye images at between 1280 × 811 and 767 × 569 pixel resolution and at up to 1:70 JPEG compression.

Biomimetic modeling of the nitrogen-centered radical postulated to occur during the inhibition of ribonucleotide reductases by 2'-azido-2'-deoxynucleotides

Ribonucleotide reductases (RNR) are essential enzymes that catalyze the reduction of ribonucleotides to 2'-deoxyribonucleotides, which is a critical step that produces precursors for DNA replication and repair. The inactivation of RNR, logically, would discontinue producing the precursors of the DNA of viral or cancer cells, which then would consequently end the cycle of DNA replication. Among different compounds that were found to be inhibitors of RNR, 2'-azido-2'-deoxynucleotide diphosphates (N3NDPs) have been investigated in depth as potent inhibitors of RNR. Decades of investigation has suggested that the inactivation of RNR by N3NDPs is a result of the formation of a nitrogen-centered radical (N·) that is covalently attached to the nucleotide at C3' and cysteine molecule C225 [3'-C(R-S-N·-C-OH)]. Biomimetic simulation reactions for the generation of the nitrogen-centered radicals similar to the one observed during the inactivation of the RNR by azionuclotides was investigated. The study included several modes: (i) theoretical calculation that showed the feasibility of the ring closure reaction between thiyl radicals and azido group; (ii) synthesis of the model azido nucleosides with a linker attached to C3' or C5' having a thiol or vicinal dithiol functionality; (iii) generation of the thiyl radical under both physiological and radiolysis conditions whose role is important in the initiation on RNR cascades; and (iv) analysis of the nitrogen-centered radical species formed during interaction between the thiyl radical and azido group by electron paramagnetic resonance spectroscopy (EPR). Characterization of the aminyl radical species formed during one electron attachment to the azido group of 2'-azido-2'-deoxyuridine and its stereospecifically labelled 1'-, 2'-, 3'-, 4'- or 5,6-[2H 2]-analogues was also examined. This dissertation gave insight toward understanding the mechanism of the formation of the nitrogen-centered radical during the inactivation of RNRs by azidonucleotides as well as the mechanism of action of RNRs that might provide key information necessary for the development of the next generation of antiviral and anticancer drugs.

A study of two calcium lines in Eridani, demonstrating the calculation of theoretical profiles by three methods,

Includes bibliography.

Theoretical evaluation of the cataract extraction-refraction-implantation techniques for intraocular lens power calculation

PURPOSE: To evaluate theoretically three previously published formulae that use intra-operative aphakic refractive error to calculate intraocular lens (IOL) power, not necessitating pre-operative biometry. The formulae are as follows: IOL power (D) = Aphakic refraction x 2.01 [Ianchulev et al., J. Cataract Refract. Surg.31 (2005) 1530]; IOL power (D) = Aphakic refraction x 1.75 [Mackool et al., J. Cataract Refract. Surg.32 (2006) 435]; IOL power (D) = 0.07x(2) + 1.27x + 1.22, where x = aphakic refraction [Leccisotti, Graefes Arch. Clin. Exp. Ophthalmol.246 (2008) 729]. METHODS: Gaussian first order calculations were used to determine the relationship between intra-operative aphakic refractive error and the IOL power required for emmetropia in a series of schematic eyes incorporating varying corneal powers, pre-operative crystalline lens powers, axial lengths and post-operative IOL positions. The three previously published formulae, based on empirical data, were then compared in terms of IOL power errors that arose in the same schematic eye variants. RESULTS: An inverse relationship exists between theoretical ratio and axial length. Corneal power and initial lens power have little effect on calculated ratios, whilst final IOL position has a significant impact. None of the three empirically derived formulae are universally accurate but each is able to predict IOL power precisely in certain theoretical scenarios. The formulae derived by Ianchulev et al. and Leccisotti are most accurate for posterior IOL positions, whereas the Mackool et al. formula is most reliable when the IOL is located more anteriorly. CONCLUSION: Final IOL position was found to be the chief determinant of IOL power errors. Although the A-constants of IOLs are known and may be accurate, a variety of factors can still influence the final IOL position and lead to undesirable refractive errors. Optimum results using these novel formulae would be achieved in myopic eyes.