Toowoomba's 'miracle girl' surfaces after being feared drowned

Musician Hannah Reardon-Smith is the woman who came back from the dead after she and her mother were plunged into last week's catastrophic flash flood in Toowoomba...

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: A systematic analysis for the Global Burden of Disease Study 2010

BACKGROUND Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time. METHODS We estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010. We estimated exposure distributions for each year, region, sex, and age group, and relative risks per unit of exposure by systematically reviewing and synthesising published and unpublished data. We used these estimates, together with estimates of cause-specific deaths and DALYs from the Global Burden of Disease Study 2010, to calculate the burden attributable to each risk factor exposure compared with the theoretical-minimum-risk exposure. We incorporated uncertainty in disease burden, relative risks, and exposures into our estimates of attributable burden. FINDINGS In 2010, the three leading risk factors for global disease burden were high blood pressure (7·0% [95% uncertainty interval 6·2-7·7] of global DALYs), tobacco smoking including second-hand smoke (6·3% [5·5-7·0]), and alcohol use (5·5% [5·0-5·9]). In 1990, the leading risks were childhood underweight (7·9% [6·8-9·4]), household air pollution from solid fuels (HAP; 7·0% [5·6-8·3]), and tobacco smoking including second-hand smoke (6·1% [5·4-6·8]). Dietary risk factors and physical inactivity collectively accounted for 10·0% (95% UI 9·2-10·8) of global DALYs in 2010, with the most prominent dietary risks being diets low in fruits and those high in sodium. Several risks that primarily affect childhood communicable diseases, including unimproved water and sanitation and childhood micronutrient deficiencies, fell in rank between 1990 and 2010, with unimproved water and sanitation accounting for 0·9% (0·4-1·6) of global DALYs in 2010. However, in most of sub-Saharan Africa childhood underweight, HAP, and non-exclusive and discontinued breastfeeding were the leading risks in 2010, while HAP was the leading risk in south Asia. The leading risk factor in Eastern Europe, most of Latin America, and southern sub-Saharan Africa in 2010 was alcohol use; in most of Asia, North Africa and Middle East, and central Europe it was high blood pressure. Despite declines, tobacco smoking including second-hand smoke remained the leading risk in high-income north America and western Europe. High body-mass index has increased globally and it is the leading risk in Australasia and southern Latin America, and also ranks high in other high-income regions, North Africa and Middle East, and Oceania. INTERPRETATION Worldwide, the contribution of different risk factors to disease burden has changed substantially, with a shift away from risks for communicable diseases in children towards those for non-communicable diseases in adults. These changes are related to the ageing population, decreased mortality among children younger than 5 years, changes in cause-of-death composition, and changes in risk factor exposures. New evidence has led to changes in the magnitude of key risks including unimproved water and sanitation, vitamin A and zinc deficiencies, and ambient particulate matter pollution. The extent to which the epidemiological shift has occurred and what the leading risks currently are varies greatly across regions. In much of sub-Saharan Africa, the leading risks are still those associated with poverty and those that affect children.

Intellectual property, innovation, and the environment (2014) edited by Peter Menell and Sarah Tran: A review

Peter S. Menell and Sarah M. Tran (ed.), Intellectual Property, Innovation and the Environment, Cheltenham (UK) and Northampton (MA): Edward Elgar, 2014, 756 pp Hardback 978 1 78195 160 6, http://www.e-elgar.com/bookentry_main.lasso?id=15063 There has been a longstanding deadlock over intellectual property and clean technologies in international climate talks. The United States — and other developed countries such as Japan, Denmark Germany, the United Kingdom, Australia, and New Zealand — have pushed for stronger and longer protection of intellectual property rights related to clean technologies. BASIC countries — such as Brazil, South Africa, India, and China — have pushed for greater flexibilities in respect of intellectual property for the purpose of addressing climate change and global warming. Small island states, least developed countries, and nations vulnerable to climate change have called for climate-adaptation and climate-mitigation technologies to be available in the public domain. In the lead-up to the United Nations Climate Summit in New York on the 23rd September 2014, it is timely to consider the debate over intellectual property, innovation, the environment, and climate change.

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1–3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region4, 5, 6, 7, 8, 9, 10, 11. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods—recursive partitioning and regression...

Ulkomaisen kirjallisuuden tuonti Suomeen 1800-luvun alkupuolella : Waseniuksen kirjakaupan kansainväliset yhteydet 1823-1836

Opinnäytetyöni tarkastelee eurooppalaisen kulttuurin kannalta keskeistä kommunikaatiovälinettä, painettua kirjaa, ja sen kansainvälistä luonnetta ja liikkumista. Teemaan perehdytään helsinkiläisen Gustaf Otto Waseniuksen (1789-1852) kirjakaupan toiminnan avulla keskittyen tarkastelemaan ulkomaisen kirjallisuuden tuomista Suomeen 1800-luvun alkupuolella. Tutkielma käsittelee ensisijaisesti itse kauppiastoimintaa: mitä kirjakauppayhteyksiä Waseniuksella oli sekä miten ja keiden ehdoilla ne toimivat. Näiden kysymysten ohessa pohdin myös itse kirjojen välityksellä tapahtunutta tiedonvälitystä. Työn tavoitteena on paljastaa, minkälaisia suomalaisten kirjakauppiaiden ja lukijoiden kirjallisuudenhankinnan sekä lukemisen kontekstit ja resurssit olivat 1800-luvun alkupuolella. Tutkielman lähteinä on käytetty Waseniuksen kirjakaupan kirjeitä ja kuitteja sekä sensuuriviranomaisten arkistoja. Tutkielmani jakautuu kolmeen osaan. Ensiksi paneudun Waseniuksen kauppaverkoston syntyyn ja sen esittelyyn: Waseniuksen kansainväliset yhteydet keskittyivät kolmelle kulttuurialueelle. Ruotsista hän sai kirjoja kaikilta merkittäviltä kustantajilta, kauppiailta sekä itsenäisesti toimivilta kirjailijoilta. Saksankielisen kulttuurin tarjontaa Wasenius pystyi hankkimaan Leipzigin kansainvälisten kirjakauppiaiden avulla. Ranskalaisen kirjallisuuden osalta Wasenius omasi toimivat yhteydet Pariisin kirjakauppiaisiin. Sen sijaan Brittein saaret jäivät vielä Waseniuksen kontaktiverkoston ulkopuolelle, samoin myös Pietarin huomattava kulttuurikeskus. Tämän jälkeen keskityn yhteyksien toimintaan. Wasenius solmi kauppakumppaniensa kanssa yleiseurooppalaisen komissionääri-sopimuksen, jonka valtuuttamana hän sai myydä kunkin ulkomaisen kauppiaan tuotteita liikkeessään. Ensiksi tarkastelen kauppiaiden välisten etäisyyksien ylittämistä. Aikakauden kuljetustavat huomioonottaen suuret etäisyydet eivät Waseniuksen kirjojen hankintaa juuri haitanneet, vaan suurkauppiaana hän pystyi käyttämään aikansa parhaat resurssit lähetystensä kuljettamiseen. Toiseksi pohdin aikakauden kauppiastoimintojen ja kulttuuripiirteiden vaikutusta kirjakauppaan. Waseniuksen toiminta kirjakauppiaana perustui taloudellisen voiton tavoittelulle, mikä tarkoitti mm. sitä, että lähetysten sisältö määrättiin etukäteen hyvin tarkasti. Ennen Suomeen saapumistaan kirjoilla piti olla varma ostaja, minkä Wasenius useimmiten varmisti ennakkotilausluetteloin ja etumaksuin. Kolmanneksi esiin nousevat 1800-luvun alun poliittiset tapahtumat, jotka osaltaan, kauppiaan silmiin kaikkein näkyvimmin, vaikuttivat kirjojen tuontiin. Sensuurin piti periaatteessa estää useiden satojen vaarallisena pidetyn kirjan levittäminen ja lukeminen Suomessa, mutta Wasenius ei suinkaan lopettanut kiellettyjen kirjojen tuontia, vaan salakuljetti sensuroitavia teoksia jatkuvasti liikkeeseensä myytäväksi. Suomalaiset viranomaiset hyväksyivät usein tämänkaltaisen toiminnan, joten venäläistä sensuuriasetusta tai hallintoa ei juuri kunnioitettu. Vertailu eurooppalaiseen kirjakauppatoimintaan osoittaa Waseniuksen omanneen erittäin hyvät kansainväliset suhteet. Tämä kuitenkin johtui niin kirjakauppatoiminnan keskittymisestä harvojen kauppiaiden käsiin kuin myös oman kustannustoiminnan vähyydestä. Tiedonvälityksen kehityksen ja kulttuurihistorian kannalta Waseniuksen kansainvälinen toiminta osoittautuu noudattelevan vielä vanhan eliittikulttuurin muotoja, mutta kirjakauppainstituution kehittyminen aivan uudenlaiseen kukoistukseen valmisteli jo kansallisen kulttuurin nousemista lähivuosikymmeninä.

An abuse of process - traditionally: Smith v Lucht [2014] QDC 302

In Smith v Lucht [2014] QDC 302 McGill DCJ considered whether in Queensland the concept of abuse of process was sufficiently broad as to encompass circumstances in which the resources of the court and the parties to be expended to determine the claim were out of all proportion to the interest at stake. Stay of proceedings - abuse of process - whether disproportionality between interest at stake and costs of litigating may amount to abuse of process - plaintiff with good cause of action entitled to pursue it.

Martha Smith

[Excerpt] Martha Smith said goodbye to her long withstanding career as Associate Director of ILR’s Office of Career Services. Smith earned a B.S. in Business Administration from California State University, Hayward in 1969. In 1976, she came to Ithaca when her husband was a Ph.D. student at Cornell, and in 1978 Smith became a temporary assistant to Professor Larry Williams. Shortly after, Smith was offered a permanent position in the Office of Career Services where she advised and befriended students for over 26 years. After retiring, Smith plans to devote more time to her community and her church. When reflecting upon her career of assisting and nurturing in the development of ILR students, Smith said, "They come in as caterpillars; they evolve, and then they leave as butterflies. They have to learn to be students, it isn’t always easy Martha Smith but they always manage. As they open up we all learn that we are more alike than we are different and together we learn to appreciate the likenesses and the differences."

Studio portrait of Sarah-Bertha Klarenmeyer nee Meyerhof called "Spatz" as a young woman. portraits women

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Studio portrait of Sarah-Bertha Klarenmeyer nee Meyerhof called Spatz Portrait Women

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A review of Taenaris Hubner (Lepidoptera: Nymphalidae: Amathusiinae) in Queensland, together with first Australian records for T. myops kirschi Staudinger and Elymnias agondas melanippe Grose-Smith (Satyrinae).

Species of the amathusiine genus Taenaris Hubner known to occur in Australia, predominantly from Torres Strait, are reviewed and illustrated. T. myops kirschi Staudinger is recorded for the first time in Australia from four male specimens collected on Dauan Island, Torres Strait. A female specimen of the satyrine Elymnias agondas melanippe Grose-Smith also collected from Dauan Island represents the first record of this taxon from Australia. The high degree of variation observed in the external facies of Taenaris from Torres Strait and reliable taxonomic separation of female specimens are discussed. Taenaris-like forms of the papilionid, Papilio aegeus ormenus Guerin-Meneville and E. a. melanippe from Torres Strait and Dauan Island respectively are illustrated and reviewed. The form of P. a. ormenus from Torres Strait that is most similar to Taenaris spp. is identified as form ormenus Guerin-Meneville variety onesimus Hewitson.

Negligible evidence for regional genetic population structure for two shark species Rhizoprionodon acutus (Rüppell, 1837) and Sphyrna lewini (Griffith & Smith, 1834) with contrasting biology

Biodiversity of sharks in the tropical Indo-Pacific is high, but species-specific information to assist sustainable resource exploitation is scarce. The null hypothesis of population genetic homogeneity was tested for scalloped hammerhead shark (Sphyrna lewini, n = 237) and the milk shark (Rhizoprionodon acutus, n = 207) from northern and eastern Australia, using nuclear (S. lewini, eight microsatellite loci; R. acutus, six loci) and mitochondrial gene markers (873 base pairs of NADH dehydrogenase subunit 4). We were unable to reject genetic homogeneity for S. lewini, which was as expected based on previous studies of this species. Less expected were similar results for R. acutus, which is more benthic and less vagile than S. lewini. These features are probably driving the genetic break found between Australian and central Indonesian R. acutus (F-statistics; mtDNA, 0.751–0.903, respectively; microsatellite loci, 0.038–0.047 respectively). Our results support the spatially homogeneous monitoring and management plan for shark species in Queensland, Australia.

New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

FTO genotype is associated with phenotypic variability of body mass index

There is evidence across several species for genetic control of phenotypic variation of complex traits1, 2, 3, 4, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using ~170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype)5, 6, 7, is also associated with phenotypic variability. We show that the results are not due to scale effects or other artefacts, and find no other experiment-wise significant evidence for effects on variability, either at loci other than FTO for BMI or at any locus for height. The difference in variance for BMI among individuals with opposite homozygous genotypes at the FTO locus is approximately 7%, corresponding to a difference of ~0.5 kilograms in the standard deviation of weight. Our results indicate that genetic variants can be discovered that are associated with variability, and that between-person variability in obesity can partly be explained by the genotype at the FTO locus. The results are consistent with reported FTO by environment interactions for BMI8, possibly mediated by DNA methylation9, 10. Our BMI results for other SNPs and our height results for all SNPs suggest that most genetic variants, including those that influence mean height or mean BMI, are not associated with phenotypic variance, or that their effects on variability are too small to detect even with samples sizes greater than 100,000.

Albert Einstein sailing with Margarete Lebach; Huntington Portraits; Couples

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