Queueing Theory And Other Applications Of Stochastic Processes Queueing And Inventory Models With Rest Periods

In this thesis we study the effect of rest periods in queueing systems without exhaustive service and inventory systems with rest to the server. Most of the works in the vacation models deal with exhaustive service. Recently some results have appeared for the systems without exhaustive service.

ReST Coursework 1516

COMP6218 coursework

Proxy and agency : the rest is literature. 'Poderes y agencia : el resto es literatura'.

Resumen en español

El uso informatizado del cuestionario de problemas sociomorales (DIT) del Rest.

Resumen basado en el de la publicación

Visualización geográfica 3D mediante un API Universal y políglota. Acercando los globos virtuales al desarrollador de mashups de mapas

La librería Javascript de código abierto Mapstraction permite al desarrollador abstraerse de las pequeñas diferencias entre las distintas APIs de mapas. Mediante el uso de esta librería, el creador de mashups de mapas puede implementar sus aplicaciones tan sólo una vez con la posibilidad de cambiar de proveedor de mapas de forma sencilla, si así se requiere. En el presente trabajo se ha extendido la funcionalidad de esta librería para el soporte de funcionalidad 3D propia de los globos virtuales, de la que hasta ahora carecía: selección del ángulo de visión, extrusión del terreno, estereoscopía 3D o inclusión de modelos tridimensionales, por citar algunas. Además, se ha realizado una integración del globo virtual de la Nasa, de código abierto, World Wind, antes apenas utilizado para el desarrollo de mashups al no disponer de un API Javascript para su fácil incorporación

Integración de la recomendación WMS-C en los estándares preexistentes en la IDE

La experiencia en el uso de los servicios de mapas basados en la especificación Web Map Service (WMS) del Open Geospatial Consortium (OGC) ha demostrado que es necesario utilizar cachés de teselas para lograr un rendimiento aceptable en aplicaciones de difusión masiva, sin embargo no hay ningún mecanismo estándar para que los clientes de mapas aprovechen, a partir de la información proporcionada por el servidor de mapas, la disponibilidad de esta caché. A la espera de que la nueva recomendación WMTS se implante suficientemente, el mecanismo más extendido es la recomendación de perfil WMS-C de OsGeo. Para conseguir que la definición de mapas que contienen servicios WMSC sea lo más automática posible, se ha ampliado el servidor Geoserver para soportar un modelo de mapas de acuerdo con la recomendación WMC con algunas extensiones ad-hoc. La extensión desarrollada para Geoserver amplía su API REST para incluir soporte de WMC. De esta forma, cuando se registra una nueva configuración de mapa, mediante un documento WMC, en el que ciertas capas están cacheadas se procede automáticamente a la activación del cacheado mediante la extensión GeoWebCache. Para la utilización de las nuevas capacidades proporcionadas a Geoserver, se ha desarrollado un cliente de mapas que identifica la existencia de capas cacheadas y procede a utilizar, según convenga, los servicios cacheados y los servicios WMS tradicionales

IDELab MapstractionInteractive: API Universal y Políglota

Continuamente aparecen nuevas plataformas de gestión de cartografía web, con el inconveniente de que cada una de ellas utiliza un API propia. Dada la gran heterogeneidad de APIs de Mapas existente, sería conveniente disponer de una librería de mapas capaz de abstraer al desarrollador de las pequeñas diferencias entre ellas. Este es el objetivo de la librería Javascript de código abierto Mapstraction. Este tipo de API recibe el nombre de «API Universal y Políglota». Gracias a Mapstraction se pueden desarrollar aplicaciones en las que el usuario puede visualizar la información cartográfica con varios proveedores, pero presenta el inconveniente de no proporcionar mecanismos de creación y/o edición. En este documento se recogen las principales novedades que presenta la librería IDELab MapstractionInteractive, una extensión de Mapstraction que ofrece nueva funcionalidad para solventar las carencias de ésta. Las nuevas funcionalidades implementadas para los proveedores que se incluyen dentro de la librería brindan al usuario la posibilidad de poder editar y crear geometrías sobre el mapa (puntos, líneas y polígonos). Por otra parte, también se implementan dentro de la librería nuevos eventos para los mapas, de forma que el programador puede tener un mayor control de lo que el usuario hace sobre éstos

API-CALC 1.0: a computer program for calculating the average probability of identity allowing for substructure, inbreeding and the presence of close relatives

Individual identification via DNA profiling is important in molecular ecology, particularly in the case of noninvasive sampling. A key quantity in determining the number of loci required is the probability of identity (PIave), the probability of observing two copies of any profile in the population. Previously this has been calculated assuming no inbreeding or population structure. Here we introduce formulae that account for these factors, whilst also accounting for relatedness structure in the population. These formulae are implemented in API-CALC 1.0, which calculates PIave for either a specified value, or a range of values, for F-IS and F-ST.

Why was urban overcrowding much more severe in Scotland than in the rest of the British Isles? Evidence from the first (1904) official household expenditure survey

This article presents an analysis of British urban working-class housing conditions in 1904, using a rediscovered survey. We investigate overcrowding and find major regional differences. Scottish households in the survey were more overcrowded despite being less poor. Investigating the causes of this overcrowding, we find little support for supply-side theories or for the idea that the Scottish households in our survey experienced particularly great variations in income, causing them to commit to overly modest accommodation. We present evidence that is consistent with idea that particularly tough Scottish tenancy and local tax laws caused excess overcrowding. We also provide evidence that Scottish workers had a relatively high preference for food, rather than housing, expenditure, which can be at least partly attributed to their inheritance of more communal patterns of urban living.

Amygdala functional connectivity with medial prefrontal cortex at rest predicts the positivity effect in older adults’ memory

As people get older, they tend to remember more positive than negative information. This age-by-valence interaction has been called “positivity effect.” The current study addressed the hypotheses that baseline functional connectivity at rest is predictive of older adults' brain activity when learning emotional information and their positivity effect in memory. Using fMRI, we examined the relationship among resting-state functional connectivity, subsequent brain activity when learning emotional faces, and individual differences in the positivity effect (the relative tendency to remember faces expressing positive vs. negative emotions). Consistent with our hypothesis, older adults with a stronger positivity effect had increased functional coupling between amygdala and medial PFC (MPFC) during rest. In contrast, younger adults did not show the association between resting connectivity and memory positivity. A similar age-by-memory positivity interaction was also found when learning emotional faces. That is, memory positivity in older adults was associated with (a) enhanced MPFC activity when learning emotional faces and (b) increased negative functional coupling between amygdala and MPFC when learning negative faces. In contrast, memory positivity in younger adults was related to neither enhanced MPFC activity to emotional faces, nor MPFC–amygdala connectivity to negative faces. Furthermore, stronger MPFC–amygdala connectivity during rest was predictive of subsequent greater MPFC activity when learning emotional faces. Thus, emotion–memory interaction in older adults depends not only on the task-related brain activity but also on the baseline functional connectivity.

Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease

Huntingtin (Htt) protein interacts with many transcriptional regulators, with widespread disruption to the transcriptome in Huntington's disease (HD) brought about by altered interactions with the mutant Htt (muHtt) protein. Repressor Element-1 Silencing Transcription Factor (REST) is a repressor whose association with Htt in the cytoplasm is disrupted in HD, leading to increased nuclear REST and concomitant repression of several neuronal-specific genes, including brain-derived neurotrophic factor (Bdnf). Here, we explored a wide set of HD dysregulated genes to identify direct REST targets whose expression is altered in a cellular model of HD but that can be rescued by knock-down of REST activity. We found many direct REST target genes encoding proteins important for nervous system development, including a cohort involved in synaptic transmission, at least two of which can be rescued at the protein level by REST knock-down. We also identified several microRNAs (miRNAs) whose aberrant repression is directly mediated by REST, including miR-137, which has not previously been shown to be a direct REST target in mouse. These data provide evidence of the contribution of inappropriate REST-mediated transcriptional repression to the widespread changes in coding and non-coding gene expression in a cellular model of HD that may affect normal neuronal function and survival.

REST: transcriptional and epigenetic regulator

Acquisition and maintenance of cell fate and potential are dependent on the complex interplay of extracellular signaling, gene regulatory networks and epigenetic states. During embryonic development, embryonic stem cells become progressively more restricted along specific lineages, ultimately giving rise to the diversity of cell types in the adult mammalian organism. Recent years have seen major advances in our understanding of the mechanisms that regulate the underlying transcriptional programmes during development. In particular, there has been a significant increase in our knowledge of how epigenetic marks on chromatin can regulate transcription by generating more or less permissive chromatin conformations. This article focuses on how a single transcription factor, repressor element-1 silencing transcription factor, can function as both a transcriptional and epigenetic regulator, controlling diverse aspects of development. We will discuss how the elucidation of repressor element-1 silencing transcription factor function in both normal and disease conditions has provided valuable insights into how the epigenome and transcriptional regulators might cooperatively orchestrate correct development.