482 resultados para Pratt
Resumo:
Esta pesquisa teve como objetivo geral analisar a racionalidade que em-basa a formao de professores atravs de EaD, atravs de descrio de prtica, nos cursos de formao de professores oferecidos a distncia de uma instituio privada de ensino superior. Como objetivos especficos pretende identificar na rela-o tutor aluno a racionalidade: prtica ou tcnica; relacionar dificuldades e/ ou faci-lidades no processo de transposio didtico-metodolgica no ambiente virtual en-tre tutor/aluno, frente proposta da racionalidade prtica. O trabalho foi desenvolvi-do no modelo qualitativo de investigao, como estudo de caso. Foram entrevista-dos 10 tutores que utilizam o ambiente virtual na modalidade distncia de uma instituio superior privada. A fundamentao terica foi referenciada em Popke-witz, na anlise da Reforma Educacional, e Boaventura Santos, com contribuies quanto politizao da tecnologia. Tambm contamos com Alarco, Prestes, Brze-zinski e Namo de Mello, que tratam das possibilidades e perplexidades na formao de profissionais da educao a partir da LDB (Lei 9.394/96). Tambm com os estu-dos das novas tecnologias, como Macedo, Sancho, Lvy, Lemos, Palloff, Pratt, Ala-va, Preti, Pellanda e Lithwin. Dessa forma, a pesquisa dirige-se para um novo olhar sobre os processos semi-presenciais do ensinar e do aprender no contexto das tec-nologias digitais. O estudo sinalizou que o EaD ainda carece de ateno especial, em vrias questes no processo educativo, entre elas, tempo de alunos e tutores e capacitao tecnolgica. Assim, busca-se contribuir para a reflexo sobre essa te-mtica to contempornea. Nessa perspectiva, o estudo no pretende se esgotar e sim, obter subsdios para futuros debates.
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Procurou-se no presente trabalho examinar o significado exato do conceito de reduo, enquanto aplicvel s cincias, particularmente Psicologia. O reducionismo, conforme foi destacado, ter de ser verificado, inicialmente sob os aspectos legais, metodolgicos e lingusticos, isto , segundo as formas de natureza mais geral. No mbito da Psicologia, foram consideradas mais detalhadas as contribuies de R. Carnap e C.C. Pratt propondo, respectivamente, uma reduo de linguagem e Fisiologia. A anlise crtica destas contribuies ressaltou suas deficincias principalmente sob dois aspectos: a rejeio da concepo de que os objetos apresentam diversos ngulos vlidos de investigao cientfica, e a ausncia de rigorosa comprovao emprica dos argumentos reducionistas enquanto passam do plano lgico para o concreto, ou ultrapassam diversos nveis ontologicamente definidos da realidade. O estudo tambm mostra a articulao do reducionismo com o problems corpo-mente, procedendo-se a um exame das principais solues, monistas e dualistas, oferecidas para solucinar a questo. A alternativa mais adequada para o exame das manisfestaes psicolgicas dever sera adoo de diversos planos de investigao ao invs de uma orientao que se caracterize pela unilateralidade. O carter complementar do resultado das diversas contribuies cientficas poder ser explorado em benefcio de uma concepo antropolgica mais rica. O desenvolvimento e a aceitao de esquemas reducionistas, longe de se apresentar como um fenmino estranho no quadro cultural contemporneo, corresponde a perspectivas filosficas que se definem em termos de um mecanismo e determinismo. Em qualquer situao, na medida em que no se pretenda contribuir para a descaracterizao da cincia, devem ser salvaguardados os critrios sintticos e semnticos como recursos para o julgamento das contribuies que se pretende cientficas. Este procedimento contudo no deve se oferecer como um obstculo a outras iniciativas, como as de ordem filosfica, que seguem o curso definido por sua prpria metodologia. Abre-se, portanto, neste nvel, a oportunidade para um trabalho de integrao mais elevado.
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Na ltima dcada, tem havido um crescente nmero de estudos focados na influncia do envolvimento fsico (EnvF) nos nveis de actividade fsica (AF). Tem sido assim possvel verificar-se que o EnvF incluindo edifcios, infra-estruturas de transporte, elementos de design e instalaes recreativas, influenciam os nveis de AF (Powell et al., 2006; Sallis, 2006). A identificao dos factores do EnvF que esto associados AF dos jovens pode revelar determinantes promissoras e levar ao desenvolvimento de estratgias de interveno mais eficazes (Sallis, Bauman & Pratt 1998). O presente estudo pretende verificar se, a existncia e acessibilidade a determinados espaos fsicos para a prtica da AF esto associados aos nveis de actividade e Aptido Fsica em alunos do 5 e 7 ano de escolaridade da RAM. Metodologia: Neste estudo participaram 2724 sujeitos de ambos os sexos, com uma mdia de 11,7 + 1,59 anos de idade, pertencentes a oito escolas da RAM. Os alunos foram avaliados nos parmetros: composio corporal (peso, altura e pregas de adiposidade tricipital e geminal); aptido aerbia (teste do vaivm); historial e participao desportiva. A percentagem de Massa Gorda foi calculada atravs da equao de Slaughter et al. (1988) e os sujeitos classificados em nveis de adiposidade de acordo com as categorias de risco de Lohman (1987). Ao nvel do ndice de Massa Corporal (IMC) todos os participantes foram categorizados segundo os valores de referncia de Cole et al. (2000 e 2007). Os dados relativos participao e historial desportivo, grupo de participao, frequncia e durao de AF foram obtidos atravs de questionrios. O EnvF foi caracterizado atravs da oferta de espaos de AF e das caractersticas dos mesmos dentro e fora da escola (raio de 800m), com base na observao directa e GPS, e entrevistas aos directores de instalaes das escolas. Resultados: Verificou-se a existncia de 71 espaos para a prtica de AF. Relativamente totalidade da amostra: 23,6% e 9,2% classificam-se, respectivamente, como sujeitos com excesso de peso e obesidade; 7% revelou participar em AF diria; e 61,7% classifica-se abaixo da zona saudvel da aptido aerbia. Foram encontradas associaes entre a prtica desportiva e os indicadores de adiposidade e aptido aerbia (p<0,05). A participao desportiva est associada oferta de espaos existentes dentro e fora das escolas.
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After five years of running at RHIC, and on the eve of the LHC heavy-ion program, we highlight the status of femtoscopic measurements. We emphasize the role interferometry plays in addressing fundamental questions about the state of matter created in such collisions, and present an enumerated list of measurements, analyses and calculations that are needed to advance the field in the coming years.
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Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP)
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Abstract Background Plasmodium vivax merozoite surface protein-1 (MSP-1) is an antigen considered to be one of the leading malaria vaccine candidates. PvMSP-1 is highly immunogenic and evidences suggest that it is target for protective immunity against asexual blood stages of malaria parasites. Thus, this study aims to evaluate the acquired cellular and antibody immune responses against PvMSP-1 in individuals naturally exposed to malaria infections in a malaria-endemic area in the north-eastern Amazon region of Brazil. Methods The study was carried out in Paragominas, Par State, in the Brazilian Amazon. Blood samples were collected from 35 individuals with uncomplicated malaria. Peripheral blood mononuclear cells were isolated and the cellular proliferation and activation was analysed in presence of 19kDa fragment of MSP-1 (PvMSP-119) and Plasmodium falciparum PSS1 crude antigen. Antibodies IgE, IgM, IgG and IgG subclass and the levels of TNF, IFN- and IL-10 were measured by enzyme-linked immunosorbent assay. Results The prevalence of activated CD4+ was greater than CD8+ T cells, in both ex-vivo and in 96h culture in presence of PvMSP-119 and PSS1 antigen. A low proliferative response against PvMSP-119 and PSS1 crude antigen after 96h culture was observed. High plasmatic levels of IFN- and IL-10 as well as lower TNF levels were also detected in malaria patients. However, in the 96h supernatant culture, the dynamics of cytokine responses differed from those depicted on plasma assays; in presence of PvMSP-119 stimulus, higher levels of TNF were noted in supernatant 96h culture of malaria patients cells while low levels of IFN- and IL-10 were verified. High frequency of malaria patients presenting antibodies against PvMSP-119 was evidenced, regardless class or IgG subclass.PvMSP-119-induced antibodies were predominantly on non-cytophilic subclasses. Conclusions The results presented here shows that PvMSP-119 was able to induce a high cellular activation, leading to production of TNF and emphasizes the high immunogenicity of PvMSP-119 in naturally exposed individuals and, therefore, its potential as a malaria vaccine candidate.
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A combined spectroscopic and ab initio theoretical study of the doubly hydrogen-bonded complex of 2-pyridone (2PY) with NH3 has been performed. The S-1 <- S-0 spectrum extends up to approximate to 1200 cm(-1) above the 0(0)(0) band, close to twice the range observed for 2PY. The S-1 state nonradiative decay for vibrations above approximate to 300 cm(-1) in the NH3 complex is dramatically slowed down relative to bare 2PY. Also, the Delta v=2,4,... overtone bands of the v(1)' and v(2)' out-of-plane vibrations that dominate the low-energy spectral region of 2PY are much weaker or missing for 2PY center dot NH3, which implies that the bridging (2PY)NH center dot center dot center dot NH3 and H2NH center dot center dot center dot O=C H-bonds clamp the 2PY at a planar geometry in the S-1 state. The mass-resolved UV vibronic spectra of jet-cooled 2PY center dot NH3 and its H/D mixed isotopomers are measured using two-color resonant two-photon ionization spectroscopy. The S-0 and S-1 equilibrium structures and normal-mode frequencies are calculated by density functional (B3LYP) and correlated ab initio methods (MP2 and approximate second-order coupled-cluster, CC2). The S-1 <- S-0 vibronic assignments are based on configuration interaction singles (CIS) and CC2 calculations. A doubly H-bonded bridged structure of C-S symmetry is predicted, in agreement with that of Held and Pratt [J. Am. Chem. Soc. 1993, 115, 9718]. While the B3LYP and MP2 calculated rotational constants are in very good agreement with experiment, the calculated H2NH center dot center dot center dot O=C H-bond distance is approximate to 0.7 angstrom shorter than that derived by Held and Pratt. On the other hand, this underlines their observation that ammonia can act as a strong H-bond donor when built into an H-bonded bridge. The CC2 calculations predict the H2NH center dot center dot center dot O distance to increase by 0.2 angstrom upon S-1 <- S-0 electronic excitation, while the (2PY)NH center dot center dot center dot NH3 H-bond remains nearly unchanged. Thus, the expansion of the doubly H-bonded bridge in the excited state is asymmetric and almost wholly due to the weakening of the interaction of ammonia with the keto acceptor group.
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We report the analysis of the SI So rotational band contours of jet-cooled 5-methyl-2-hydroxypyrimidine (5M2HP), the enol form of deoxythymine. Unlike thymine, which exhibits a structureless spectrum, the vibronic spectrum of 5M2HP is well structured, allowing us to determine the rotational constants and the methyl group torsional barriers in the S-0 and S-1 states. The 0(0)(0), 6a(0)(1), 6b(0)(1), and 14(0)(1) band contours were measured at 900 MHz (0.03 cm(-1)) resolution using mass-specific two-color resonant two-photon ionization (2C-R2PI) spectroscopy. All four bands are polarized perpendicular to the pyrimidine plane (>90% c type), identifying the S-1 <- S-0 excitation of 5M2HP as a 1n pi* transition. All contours exhibit two methyl rotor subbands that arise from the lowest 5-methyl torsional states 0A '' and 1E ''. The S-0 and S-1 state torsional barriers were extracted from fits to the torsional subbands. The 3-fold barriers are V-3 '' = 13 cm(-1) and V3' = SI cm(-1); the 6-fold barrier contributions V-6 '' and V-6' are in the range of 2-3 cm(-1) and are positive in both states. The changes of A, B, and C rotational constants upon S-1 <- S-0 excitation were extracted from the contours and reflect an "anti-quinoidal" distortion. The 0(0)(0) contour can only be simulated if a 3 GHz Lorentzian line shape is included, which implies that the S-1(1n pi*) lifetime is similar to 55 ps. For the 6a(0)(1) and 6b(0)(1) bands, the Lorentzian component increases to 5.5 GHz, reflecting a lifetime decrease to similar to 30 ps. The short lifetimes are consistent with the absence of fluorescence from the 1n pi* state. Combining these measurements with the previous observation of efficient intersystem crossing (ISC) from the Si state to a long-lived T-1((3)n pi*) state that lies similar to 2200 cm(-1) below [S. Lobsiger, S. et al. Phys. Chem. Chem. Phys. 2010, 12, 5032] implies that the broadening arises from fast intersystem crossing with k(ISC) approximate to 2 x 10(10) s(-1). In comparison to 5-methylpyrimidine, the ISC rate is enhanced by at least 10 000 by the additional hydroxy group in position 2.
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Question and answer session with presenters Auvo Kostiainen, William Pratt, and Richard Hudelson.
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Farm protest in the United States attracted widespread attention in the 1930s as militant farmers interfered with foreclosure sales, demonstrated at county court houses and state capitals, and blocked highways and stopped trains to prevent crops and livestock from going to market in an effort to raise farm prices. The best known of the protest groups was the Farmers Holiday Association, which was formed in 1932. Prior to the Holiday, however, a left-wing group organized by Communists in 1930 known as the United Farmers League (UFL) gained an initial following in the cutover country of the Upper Peninsula of Michigan, northern Wisconsin, northern Minnesota, and parts of the Dakotas and northeast Montana. Finnish Americans dominated the UFL in the Upper Midwest and in a few locales in the Dakotas. Evidence for this high level of influence comes from the fact that the head of the Communist Partys Agrarian Department was Henry Puro, a key figure in Finnish American Communist circles and a member of the Partys Politburo. This paper will focus on Finnish American involvement in the UFL and, to a lesser extent, the broader-based Farmers Holiday movement.