Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States

Lemur tyrosine kinase-3 (LMTK3) was recently identified as an estrogen receptor (ER)-α modulator related to endocrine therapy resistance, and its polymorphisms rs9989661 (T>C) T/T genotype and rs8108419 (G>A) G/G or A/G genotype predicted improved outcomes in breast cancer. Because different predominant ER distributions link to breast and gastric cancer and little is known of the prognostic role of LMTK3 in gastric cancer, this study was carried out to clarify the prognostic role of these polymorphisms in gastric cancer. One-hundred and sixty-nine Japanese and 137 U.S. patients with localized gastric adenocarcinoma were enrolled. Genomic DNA was extracted from blood or tissue, and all samples were analyzed by PCR-based direct DNA sequencing. Overall, these polymorphisms were not associated with survival in both cohorts. When gender was considered, in multivariate analysis, harboring rs9989661 T/T genotype was associated with disease-free survival [HR, 4.37; 95% confidence interval (CI), 2.08-9.18; P < 0.0001] and overall survival (OS; HR, 3.69; 95% CI, 1.65-8.24; P = 0.0014) in the Japanese males and time to recurrence (HR, 7.29; 95% CI, 1.07-49.80; P = 0.043) in the U.S. females. Meanwhile, harboring rs8108419 G/G genotype was associated with OS in the Japanese females (HR, 3.04; 95% CI, 1.08-8.56; P = 0.035) and the U.S. males (HR, 3.39; 95% CI, 1.31-8.80; P = 0.012). The prognostic role of these polymorphisms may be negative in gastric cancer. These findings suggest that the estrogen pathway may play a prognostic role in patients with gastric cancer but this may be dependent on the regional differences both in physiology and genetic alterations of gastric cancer.

Geologia e génese do relevo da Rocha da Pena (Algarve, Portugal) e o seu enquadramento educativo

Dissertação mest., Biologia e Geologia, Universidade do Algarve, 2006

Os vitrais do Palácio da Pena e a colecçao de D. Fernando II: contributos para o seu estudo

Tese de mestrado, Arte, Património e Teoria do Restauro, Universidade de Lisboa, Faculdade de Letras, 2011

Karta öfver Helsingfors omgifningar upptagande delar af Helsinge, Sibbo, Esbo och Kyrkslätt m. fl. socknar

Mittakaava laskettu janamittakaavasta

Revue des livres anciens : documents d'histoire littéraire, de bibliographie & de bibliophilie / direction Pierre Louÿs ; rédaction Louis Loviot

1914 (T1).

Revue des livres anciens : documents d'histoire littéraire, de bibliographie & de bibliophilie / direction Pierre Louÿs ; rédaction Louis Loviot

1917 (T2).

Sondages de l'opinion publique française / Service de sondages et statistiques ; Comité directeur Pascal Copeau, Pierre Hervé, Yvon Morandat, Max Barioux

1944/05/23 (N2).

Sondages de l'opinion publique française / Service de sondages et statistiques ; Comité directeur Pascal Copeau, Pierre Hervé, Yvon Morandat, Max Barioux

1944/06/26 (N6).

Sondages de l'opinion publique française / Service de sondages et statistiques ; Comité directeur Pascal Copeau, Pierre Hervé, Yvon Morandat, Max Barioux

1944/09/15.

Sondages de l'opinion publique française / Service de sondages et statistiques ; Comité directeur Pascal Copeau, Pierre Hervé, Yvon Morandat, Max Barioux

1944/05/28 (N3).

Sondages de l'opinion publique française / Service de sondages et statistiques ; Comité directeur Pascal Copeau, Pierre Hervé, Yvon Morandat, Max Barioux

1944/07/10 (N10).