c-mos and cdc2 Cooperate in the Translational Activation of Fibroblast Growth Factor Receptor-1 during Xenopus Oocyte Maturation

During oocyte maturation in Xenopus, previously quiescent maternal mRNAs are translationally activated at specific times. We hypothesized that the translational recruitment of individual messages is triggered by particular cellular events and investigated the potential for known effectors of the meiotic cell cycle to activate the translation of the FGF receptor-1 (XFGFR) maternal mRNA. We found that both c-mos and cdc2 activate the translation of XFGFR. However, although oocytes matured by injection of recombinant cdc2/cyclin B translate normal levels of XFGFR protein, c-mos depletion reduces the level of XFGFR protein induced by cdc2/cyclin B injection. In oocytes blocked for cdc2 activity, injection of mos RNA induced low levels of XFGFR protein, independent of MAPK activity. Through the use of injected reporter RNAs, we show that the XFGFR 3′ untranslated region inhibitory element is completely derepressed by cdc2 alone. In addition, we identified a new inhibitory element through which both mos and cdc2 activate translation. We found that cdc2 derepresses translation in the absence of polyadenylation, whereas mos requires poly(A) extension to activate XFGFR translation. Our results demonstrate that mos and cdc2, in addition to functioning as key regulators of the meiotic cell cycle, cooperate in the translational activation of a specific maternal mRNA during oocyte maturation.

Reise in Ostafrika in den Jahren 1903-1905, mit Mitteln der Hermann und Elise geb. Heckmann Wentzel-Stiftung ausgeführt. Wissenschaftliche Ergebnisse.

Contributions in German, English, French or Italian.

Storia di cinque mesi del reame delle Due Sicilie (da gennajo a maggio 1859); ricordi.

Mode of access: Internet.

Bryologia europaea; sue, Genera muscorum europaeorum monographice illustrata auctoribus Ph. Bruch, W. Ph. Schimper & Th. Gümbel, editore W. Ph. Schimper ...

"Musci europaei novi; vel, Bryologiae europaeae supplementum auctore W. Ph. Schimper ..." (1 v. (various pagings) plates) issued 1864-[66]

Deutschlands flora in abbildungen nach der natur mit beschreibungen.

Filices, Musci, Hepaticae, Lichens, Algae.

School of Nursing Class of 1980

Top Row: Debbi Anderson, Cherie Armstrong, Diane Arney, Grace Ball, Marie Bazil, Suzanne Bihan, Nancy Black, Ellen Bochenck, Lisa Bramble, Ann Marie Brissette, Mary Brock, Gale Brown, Nancy Buhl, Judith Burek, Dana Leigh Burn, Mari Byce

Row 2: Dianne Byrd, Diane Cary, Julie Rosanne Cherno, Susan Copland, Lisa Corso, Sharon Corzine, Elsa Cowan, Linda Crawley, Constance D Anna, Mary Daly, Julie De May, Janet Dean, Lwah Ann Dennis, Leslie Jean De Noon, Barbara Deur, Marilynn Dowdy

Row 3: Laurie B. Dreisbach, Patricia Dvorak, Mary Earle, Judith Eason, Charlene Eickholt, Kathryn Elden, Susan Bourget, B.M. Rutkowski, J.Sebring-Mammel, Joan Kessler, Gregory Hazle, Rosa Ohno, Miriam Elgent, Micky Erickson, Kathleen Evans, Cathleen Fasse, Martha Finkelstein, Edie Firshman

Row 4: Susan Fitzpatrick, Lynn foley, Barbara Fredal, Lisa Ghormley, Susan Green, Carol Grishaw, Jennifer Hayden, Susan Hewens, Brenda J. Hooker, M. Karen Harning, Jean Huneke, Rose Hunter

Row 5: Joyce Jackson, Janet James, Mary Jesse, Christy Jones, Kathy Joy, Debra kadlec, Therese Keating, Ann Marie Kelly, Carol Key, Karen Dickstein, Jill Knechtel, Robin Kruger

Row 6: Mary Beth Kyko, Catherine Lawrence, Joni Lawrence, Eun Lee, Amy Long, Kathey F. Lord, Johanna Lund, Elizabeth Mac Kinnon, Marilyn Mackovjak, Lisa Mann, rose Marentette, Carmen McDowell

Row 7: Molly Mitchell, Mary Molewyk, Sandra Musci, Susan Nevins, Janet Newman, Marcy L. Ortquist, Jeanmarie Otto, Marci Peterhans, Marquite Pierce, Janet Pierson, Rachel Plumley, Frances Potasnik, Cynthia pressprich, Susan J. Robertson, Gilbert RodriqueZ, Deborah Romano, Deborah Ross, Patricia Rouen

Row 8: Abby Scholnick, Nancy Schuster, Cynthia Schwartz, Mary Ellen Sitek, Marqaret Smith, Ann Marie Smith, Cindy Smith, Julie Smrcka, Susan St. Onge, Michelle Stafford, Brenda Stallings, Nancy Steffler, Louise Sullivan, Laure Szatkowski, Bonnie R. Temple, Patricia A. Tevlin

Row 9: Linda L. Travis, Margaret Turner, Heidi Unger, Grace M.J. Valmassoi, Sally Van fleeren, Anne VanLoon, Jan Veseth, Anne MArie Villeneuve, Cynthia vrable, Lori E. Weyland, Theresa Wish, Anne Witham, Laura Wollum, Marla Young

Catalogue of Canadian plants ...

Part 6 is by John Macoun and N. C. Kindberg.

Botany of Rodriguez

Title from spine.