Chemical composition, circadian rhythm and antibacterial activity of essential oils of piper divaricatum: a new source of safrole

The essential oils from leaves, stems and fruits of Piper divaricatum were analyzed by GC-MS. The tissues showed high safrole content: leaves (98%), fruits (87%) and stems (83%), with yields of 2.0, 4.8 and 1.7%, respectively. This is a new alternative source of safrole, a compound widely used as a flavoring agent and insecticide. The leaf's oil showed antibacterial activity against gram-negative bacteria while safrole was active against Salmonella Typhimurium and Pseudomonas aeruginosa. In addition, the study of circadian rhythm of the safrole concentration in the essential oils of leaves showed a negligible variation of 92 to 98%.

[Preludes without rhythm]

Soitinnus: piano.

Mini-Mu insertions in the tetracycline resistance determinant from Proteus mirabilis

The inducible tetracycline resistance determinant isolated from Proteus mirabilis cloned into the plasmid pACYC177 was mutagenized by insertion of a mini-Mu-lac phage in order to define the regions in the cloned sequences encoding the structural and regulatory proteins. Three different types of mutants were obtained: one lost the resistance phenotype and became Lac+; another expressed the resistance at lower levels and constitutively; the third was still dependent on induction but showed a lower minimal inhibitory concentration. The mutant phenotypes and the locations of the insertions indicate that the determinant is composed of a repressor gene and a structural gene which are not transcribed divergently as are other known tetracycline determinants isolated from Gram-negative bacteria

[Urbium Londini et West-Monasterii nec non suburbii Southwark accurata iconographia = Neuester Grundris der Staedte London und West-Münster sammt der Vorstadt Southwark]

Irtokartta

A comparative analysis of preprocessing techniques of cardiac event series for the study of heart rhythm variability using simulated signals

In the present study, using noise-free simulated signals, we performed a comparative examination of several preprocessing techniques that are used to transform the cardiac event series in a regularly sampled time series, appropriate for spectral analysis of heart rhythm variability (HRV). First, a group of noise-free simulated point event series, which represents a time series of heartbeats, was generated by an integral pulse frequency modulation model. In order to evaluate the performance of the preprocessing methods, the differences between the spectra of the preprocessed simulated signals and the true spectrum (spectrum of the model input modulating signals) were surveyed by visual analysis and by contrasting merit indices. It is desired that estimated spectra match the true spectrum as close as possible, showing a minimum of harmonic components and other artifacts. The merit indices proposed to quantify these mismatches were the leakage rate, defined as a measure of leakage components (located outside some narrow windows centered at frequencies of model input modulating signals) with respect to the whole spectral components, and the numbers of leakage components with amplitudes greater than 1%, 5% and 10% of the total spectral components. Our data, obtained from a noise-free simulation, indicate that the utilization of heart rate values instead of heart period values in the derivation of signals representative of heart rhythm results in more accurate spectra. Furthermore, our data support the efficiency of the widely used preprocessing technique based on the convolution of inverse interval function values with a rectangular window, and suggest the preprocessing technique based on a cubic polynomial interpolation of inverse interval function values and succeeding spectral analysis as another efficient and fast method for the analysis of HRV signals

Bohemiae Regnum in XII circulus divisum : cum Com. Glac. et distr. Egerano ceterique circumjacentibus terris ex Müllerianis alysque chorographicis subsidys delineatum

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

新鐫全像武穆精忠傳Xin juan quan xiang wu mu jing zhong zhuan.Histoire de Yue Fei, nouvelle édition illustrée.

Par Li Chun fang, avec préface de l'auteur. Édition de Li Zhuo wu. Histoire de Yue Fei, de 1126 à 1155. Portraits des principaux personnages.8 livres.

旨准頒行詔書總目Zhi zhun ban xing zhao shu zong mu.Table de décrets du chef des Tai ping.

Contenant : 1° la table des décrets et pièces diverses comme dans le recueil précédent ; 2° un fragment de la Bible en Chinois 2e livre seulement, de Jacob jusqu'à (Moïse) publié par les Tai ping.

本草綱目Ben cao gang mu.Traité des simples.

Contient : IBin hu mo xue ; IIMo jue kao zheng ; IIIQi jing ba mo kao ; IVBen cao gang mu

三藥齋重訂本草綱目San yue zhai chong ding ben cao gang mu.Traité des simples, réédition de la salle San yue.

Édition de 1735, imitée de celle de 1717 (Chinois 5264-5271, article I). Préfaces, table, avertissement, dédicace, introduction.3 livres de figures (manque le texte).