A multi-center study of ACE and the risk of late-onset Alzheimer's disease

A key pathological feature of late-onset Alzheimer's disease (LOAD) is the abnormal extracellular accumulation of the amyloid-ß (Aß) peptide. Thus, altered Aß degradation could be a major contributor to the development of LOAD. Variants in the gene encoding the Aß-degrading enzyme, angiotensin-1 converting enzyme (ACE) therefore represent plausible candidates for association with LOAD pathology and risk. Following Alzgene meta-analyses of all published case-control studies, the ACE variants rs4291 and rs1800764 showed significant association with LOAD risk. Furthermore ACE haplotypes are associated with both plasma ACE levels and LOAD risk. We tested three ACE variants (rs4291, rs4343, and rs1800764) for association with LOAD in ten Caucasian case-control populations (n = 8,212). No association was found using multiple logistic models (all p > 0.09). We found no population heterogeneity (all p > 0.38) or evidence for association with LOAD risk following meta-analysis of the ten populations for rs4343 (OR = 1.00), rs4291 (OR = 0.97), or rs1800764 (OR = 0.99). Although we found no haplotypic association in our complete dataset (p = 0.51), a significant global haplotypic p-value was observed in one population (p = 0.007) due to an association of the H3 haplotype (OR = 0.72, p = 0.02) and a trend towards an association of H4 (OR = 1.38, p = 0.09) and H7 (OR = 2.07, p = 0.08) although these did not survive Bonferroni correction. Previously reported associations of ACE variants with LOAD will be diminished following this study. At best, ACE variants have modest effect sizes, which are likely part of a complex interaction between genetic, phenotypic and pharmacological effects that would be undetected in traditional case-control studies.

Formação, aprendizagem e organizações aprendentes

Numa era de grande mudança a todos níveis, como seja o aparecimento constante de tecnologia que permite o acesso à informação, todos os indivíduos, qualquer que seja o seu grão de formação inicial, devem estar atentos e manter-se actualizados, é uma questão de sobrevivência.

Retaining repatriates: an exploratory study in portuguese companies

This study aims to understand the factors which may explain the retention of repatriates from companies acting within Portugal. These factors can be related either to the individual, or to the work, to the organisation or to non-working contexts. Eight companies located in Portugal have participated in this study. Several semi-structured interviews were done to 16 organizational representatives and to 28 repatriates. The obtained results show that the repatriates’ retention on the visited companies may be influenced by several categories of factors. We can conclude that it is (1) the good relation with the leadership, (2) the recognition of the performed job but, also (3) the seniority, (4) the age and the (5) depressed national job market. These are the major factors that emerge as relevant factors for the retention. Hence, there is not only one category of explaining determining factors for the retention decision, but there are several. These findings will be discussed in detail and implications and suggestions for future research will be proposed as well.

Certificación de las normas ISO-9000 aplicado a la industria manufacturera del ramo de la electrónica

Tesis (Maestría en Ciencias de la Administración con Especialidad en Producción y Calidad) UANL

Guía para la creación de un programa de marketing organizado en torno a las necesidades y objetivos de las pequeñas y medianas empresas

Tesis (Maestría en Ciencias de la Administración con Especialidad en Relaciones Industriales) UANL

Amor y erotismo en la poesía de David Huerta : lectura de historia

Tesis (Maestría en Letras Españolas) UANL

Resultado de un programa informativo de VIH

Tesis (Maestría en Ciencias de Enfermería con Enfasis en Administración de Servicios) UANL

Cambios en el estilo de vida durante la semana y su relación con el turno de trabajo

Tesis (Maestría en Psicología Social) UANL

Caries dental y diabetes mellitus no insulino dependiente

Tesis (Maestría en Salud Pública con Especialidad en Odontología Social) UANL.

Autoeficacia, asertividad y consumo de tabaco y alcohol en estudiantes de secundaria

Tesis (Maestría en Ciencias de Enfermería con énfasis en Salud Comunitaria) U.A.N.L.

Propuesta de un modelo fiscal régimen de actividades empresariales en relación con el régimen de pequeños contribuyentes para ISR en México

Tesis (Maestría en Contaduría Pública con Especialidad en Impuestos) U.A.N.L.

La vinculación como estrategia para el desarrollo académico del Diseño Industrial

Tesis (Maestría en Ciencias con Orientación en Gestión e Innovación del Diseño) UANL, 2012.

Un marco integrado para el control y gestión de incendios forestales.

Tesis (Maestría en Ciencias en Ingeniería de Sistemas) UANL, 2011.

Complicaciones periodontales por el uso de aretes en labio y

Tesis (Maestría en Ciencias Odontológicas con Especialidad en Periodoncia) UANL, 2012.

Ritmos circadianos en los componentes de las funciones ejecutivas.

Tesis (Doctor en Filosofía con Especialidad en Psicología) UANL, 2010.