BRCA1--conductor of the breast stem cell orchestra:the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast cancer

Breast cancer treatment has been increasingly successful over the last 20 years due in large part to targeted therapies directed against different subtypes. However, basal-like breast cancers still represent a considerable challenge to clinicians and scientists alike since the pathogenesis underlying the disease and the target cell for transformation of this subtype is still undetermined. The considerable similarities between basal-like and BRCA1 mutant breast cancers led to the hypothesis that these cancers arise from transformation of a basal cell within the normal breast epithelium through BRCA1 dysfunction. Recently, however, a number of studies have called this hypothesis into question. This review summarises the initial findings which implicated the basal cell as the cell of origin of BRCA1 related basal-like breast cancers, as well as the more recent data which identifies the luminal progenitor cells as the likely target of transformation. We compare a number of key studies in this area and identify the differences that could explain some of the contradictory findings. In addition, we highlight the role of BRCA1 in breast cell differentiation and lineage determination by reviewing recent findings in the field and our own observations suggesting a role for BRCA1 in stem cell regulation through activation of the p63 and Notch pathways. We hope that through an increased understanding of the BRCA1 role in breast differentiation and the identification of the cell(s) of origin we can improve treatment options for both BRCA1 mutant and basal-like breast cancer subgroups.

Tish Marches On due date card

This is a due date card for the book titled Tish Marches On, stamped with Works Progress Administration.

University Summer Quarter Chorus and High School Music Intensive Orchestra, July 11, 1940

Concert program for Summer Quarter Music, July 11, 1940

Symphony Orchestra, February 11, 1940

Concert program for Symphony Orchestra, February 11, 1940

University Symphony Orchestra, May 29, 1975

Concert program for University Symphony Orchestra, May 29, 1975

The University Symphony Orchestra, December 3, 1976

Concert program for The University Symphony Orchestra, December 3, 1976

University Symphony Orchestra, January 30, 1977

Concert program for University Symphony Orchestra, January 30, 1977

University Symphony Orchestra, February 25, 1977

Concert program for University Symphony Orchestra, February 25, 1977

The University Symphony Orchestra, January 26, 1982

Concert program for The University Symphony Orchestra, January 26, 1982

The University Symphony Orchestra, January 28, 1966

Concert Program for The University Symphony Orchestra, January 28, 1966

The University Symphony Orchestra, March 10, 1967

Concert program for The University Symphony Orchestra, March 10, 1967

Concerto Concert with Members of the University Symphony Orchestra, May 14, 1969

Concert program for Concerto Concert with members of the University Symphony Orchestra, May 14, 1969

Work satisfaction and affective commitment of classical musicians: The European Union Youth Orchestra

This work project investigates career paths in the music field, by testing the application of general career and social theories for musicians. Using a sample from the European Union Youth Orchestra’ Alumni, the Boundaryless Career Theory, Intelligent Career Framework and Social Identity Theory were analysed through the impact on individual outcomes - musicians’ Overall work satisfaction and Affective commitment to the orchestra. Results suggest support for the three theories, and show their applicability for classical musicians’ careers.

4-6-20, signature de la Paix avec la Hongrie, départ des délégués hongrois [sur les marches du perron] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 59533