A multithickness sea ice model accounting for sliding friction

A multithickness sea ice model explicitly accounting for the ridging and sliding friction contributions to sea ice stress is developed. Both ridging and sliding contributions depend on the deformation type through functions adopted from the Ukita and Moritz kinematic model of floe interaction. In contrast to most previous work, the ice strength of a uniform ice sheet of constant ice thickness is taken to be proportional to the ice thickness raised to the 3/2 power, as is revealed in discrete element simulations by Hopkins. The new multithickness sea ice model for sea ice stress has been implemented into the Los Alamos “CICE” sea ice model code and is shown to improve agreement between model predictions and observed spatial distribution of sea ice thickness in the Arctic.

The response of the sea ice edge to atmospheric and oceanic jet formation

The sea ice edge presents a region of many feedback processes between the atmosphere, ocean, and sea ice (Maslowski et al.). Here the authors focus on the impact of on-ice atmospheric and oceanic flows at the sea ice edge. Mesoscale jet formation due to the Coriolis effect is well understood over sharp changes in surface roughness such as coastlines (Hunt et al.). This sharp change in surface roughness is experienced by the atmosphere and ocean encountering a compacted sea ice edge. This paper presents a study of a dynamic sea ice edge responding to prescribed atmospheric and oceanic jet formation. An idealized analytical model of sea ice drift is developed and compared to a sea ice climate model [the Los Alamos Sea Ice Model (CICE)] run on an idealized domain. The response of the CICE model to jet formation is tested at various resolutions. It is found that the formation of atmospheric jets at the sea ice edge increases the wind speed parallel to the sea ice edge and results in the formation of a sea ice drift jet in agreement with an observed sea ice drift jet (Johannessen et al.). The increase in ice drift speed is dependent upon the angle between the ice edge and wind and results in up to a 40% increase in ice transport along the sea ice edge. The possibility of oceanic jet formation and the resultant effect upon the sea ice edge is less conclusive. Observations and climate model data of the polar oceans have been analyzed to show areas of likely atmospheric jet formation, with the Fram Strait being of particular interest.

Processes controlling surface, bottom and lateral melt of Arctic sea ice in a state of the art sea ice model

We present a modelling study of processes controlling the summer melt of the Arctic sea ice cover. We perform a sensitivity study and focus our interest on the thermodynamics at the ice–atmosphere and ice–ocean interfaces. We use the Los Alamos community sea ice model CICE, and additionally implement and test three new parametrization schemes: (i) a prognostic mixed layer; (ii) a three equation boundary condition for the salt and heat flux at the ice–ocean interface; and (iii) a new lateral melt parametrization. Recent additions to the CICE model are also tested, including explicit melt ponds, a form drag parametrization and a halodynamic brine drainage scheme. The various sea ice parametrizations tested in this sensitivity study introduce a wide spread in the simulated sea ice characteristics. For each simulation, the total melt is decomposed into its surface, bottom and lateral melt components to assess the processes driving melt and how this varies regionally and temporally. Because this study quantifies the relative importance of several processes in driving the summer melt of sea ice, this work can serve as a guide for future research priorities.

Relation of pretreatment sequence diversity in NS5A region of HCV genotype 1 with immune response between pegylated-INF/ribavirin therapy outcomes

Hepatitis C virus (HCV) infection frequently persists despite substantial virus-specific immune responses and the combination of pegylated interferon (INF)-alpha and ribavirin therapy. Major histocompatibility complex class I restricted CD8+ T cells are responsible for the control of viraemia in HCV infection, and several studies suggest protection against viral infection associated with specific HLAs. The reason for low rates of sustained viral response (SVR) in HCV patients remains unknown. Escape mutations in response to cytotoxic T lymphocyte are widely described; however, its influence in the treatment outcome is ill understood. Here, we investigate the differences in CD8 epitopes frequencies from the Los Alamos database between groups of patients that showed distinct response to pegylated alpha-INF with ribavirin therapy and test evidence of natural selection on the virus in those who failed treatment, using five maximum likelihood evolutionary models from PAML package. The group of sustained virological responders showed three epitopes with frequencies higher than Non-responders group, all had statistical support, and we observed evidence of selection pressure in the last group. No escape mutation was observed. Interestingly, the epitope VLSDFKTWL was 100% conserved in SVR group. These results suggest that the response to treatment can be explained by the increase in immune pressure, induced by interferon therapy, and the presence of those epitopes may represent an important factor in determining the outcome of therapy.

Forskning med juridiska förvecklingar : Om tolkningsflexibilitet i kontroversen om mässlingsvaccination och autism

Medical research with jurisdictional consequences: interpretative flexibility in the controversy over MMR vaccination and autism Based on the empirical case of the controversy of MMR vaccination and autism around the turn of the millennium, this paper argues for the analytical importance of the concept of “interpretative flexibility”. As shown, this concept is useful not only for the small subfield of sociology of scientific knowledge (SSK) but also for the broader social sciences. First we analyse, by reference to interpretative flexibility, the initial dispute within medical research concerning evidence for and against a possible link between the measles component of the MMR vaccine and autism. In a second step we move beyond this traditional application of the concept, showing how the interpretative flexibility of the research results remains in society although consensus has been reached in the medical community. This further step is exemplified by two legal events, in Sweden and the US respectively. In both these cases the difficulties in providing uncontested evidence affected institutions and practices at great distance and with different outcomes. Our findings suggest the importance of not only applying the concept of interpretative flexibility to classical scientific laboratory disputes, but also connecting it to its societal manifestations.

Plasma amino acid response after ingestion of different whey protein fractions

Background and objectives The digestion rate of proteins and subsequent absorption of amino acids can independently modulate protein metabolism. The objective of the present study was to examine the blood amino acid response to whey protein isolate (WPI), β-lactoglobulin-enriched WPI, hydrolysed WPI and a flavour-identical control.

Methods Eight healthy adults (four female, four male) were recruited (mean±standard error of the mean: age, 27.0±0.76 years; body mass index, 23.2±0.8 kg/cm2) and after an overnight fast consumed 500 ml of each drink, each containing 25g protein, in a cross-over design. Blood was taken at rest and then every 15 min for 2 h post ingestion.

Results Ingesting the β-lactoglobulin-enriched WPI drink resulted in significantly greater plasma leucine concentrations at 45-120 min and significantly greater branched-chain amino acid concentrations at 60-105 min post ingestion compared with hydrolysed WPI. No differences were observed between WPI and β-lactoglobulin-enriched WPI, and all protein drinks resulted in elevated blood amino acids compared with flavour-identical control.

Conclusions In conclusion, whole proteins resulted in a more rapid absorption of leucine and branched-chain amino acid into the blood compared with the hydrolysed molecular form of whey protein.

Desconcentração da polícia técnica e científica do Estado de Rondônia: uma política de administração pública

Este estudo apresenta como questão central: Por que desconcentrar o Departamento de Polícia Técnica e Científica com a criação e implantação de coordenadorias nas sub-regiões da Secretaria de Segurança Pública, Defesa e Cidadania do Estado de Rondônia? Para responder tal questão que norteia o presente estudo volta-se o enfoque para a gestão dos serviços praticados pelos órgãos de perícia técnica nas diversas regiões do Estado visando o princípio da eficiência e da produtividade, bem como do aspecto social dos órgãos de segurança pública, pois, em última análise, são estes os que deveriam agir em conjunto com a sociedade visando a garantia da aplicação da lei e da justiça a todos, com o objetivo de contribuir na gestão dos órgãos regionais, além de atender ao controle social pelo cidadão, com a criação de coordenadorias regionais naquela instituição. Como instrumento para coleta de dados optou-se pelo questionário com perguntas selecionadas sobre os conceitos dos temas abordados, e sobre as perspectivas de mudanças de formatação diferenciada da perícia no interior do estado aplicado através do fórum dos Peritos Criminais do Estado de Rondônia, via internet. Também foram realizadas pesquisas bibliográficas, documentais e a análise de dados populacionais, geográficos, de ocorrências policiais e de número de peritos. Os dados mostram que entre os profissionais da área existe um desconhecimento da distinção entre os conceitos de desconcentração e de descentralização. Apesar desse fato, as respostas apontam para a unanimidade com relação à necessidade de haver uma desconcentração do setor, que visa o reconhecimento das unidades regionais e a melhoria do trabalho produzido para a sociedade. Ao confrontar os dados referentes à área de atuação de cada uma das sub-regiões do Instituto de Criminalística, dentre as quais as unidades existentes e as desarticuladas (com área geográfica de atuação, população atingida e número de ocorrências realizadas por período de tempo escolhido), com os dados obtidos simultaneamente na sede fixada à capital do estado, ficou ainda mais clara a necessidade de desconcentração da perícia criminal no interior do estado, constatando-se a urgente e necessária criação de polos gestores em sintonia com o órgão central, desde que tal seja realizado como política pública.

Relation of pretreatment sequence diversity in NS5A region of HCV genotype 1 with immune response between pegylated-INF/ribavirin therapy outcomes

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Las transformaciones tecnológicas mundiales y sus consecuencias para América Latina y el Caribe = World technological change and its consequences for Latin America and the Caribbean

Examina las manifestaciones presentes de las transformaciones tecnologicas en curso e intenta establecer las principales tendencias de cambio y avance, con sus impactos estructurales, asi como los posibles efectos sobre la Division Internacional del Trabajo.

Directrices para el ingreso de información en la hoja de análisis de la base de datos TRANDIS

Entrega pautas para el registro en la Hoja de Analisis, de la informacion que se ingresa a la base de datos del Sistema de Informacion Documental TRANDIS en donde se identifica y describe los documentos existentes en la Division de Transporte de la CEPAL.

Dynamics of doublon-holon pairs in Hubbard two-leg ladders

The dynamics of holon-doublon pairs is studied in Hubbard two-leg ladders using the time-dependent density matrix renormalization group method. We find that the geometry of the two-leg ladder, which is qualitatively different from a one-dimensional chain due to the presence of a spin gap, strongly affects the propagation of a doublon-holon pair. Two distinct regimes are identified. For weak interleg coupling, the results are qualitatively similar to the case of the propagation previously reported in Hubbard chains, with only a renormalization of parameters. More interesting is the case of strong interleg coupling where substantial differences arise, particularly regarding the double occupancy and properties of the excitations such as the doublon speed. Our results suggest a connection between the presence of a spin gap and qualitative changes in the doublon speed, indicating a weak coupling between the doublon and the magnetic excitations.

Implementation of monotonic higher order upwind scheme in KIVA 4

KIVA is a FORTRAN code developed by Los Alamos national lab to simulate complete engine cycle. KIVA is a flow solver code which is used to perform calculation of properties in a fluid flow field. It involves using various numerical schemes and methods to solve the Navier-Stokes equation. This project involves improving the accuracy of one such scheme by upgrading it to a higher order scheme. The numerical scheme to be modified is used in the critical final stage calculation called as rezoning phase. The primitive objective of this project is to implement a higher order numerical scheme, to validate and verify that the new scheme is better than the existing scheme. The latest version of the KIVA family (KIVA 4) is used for implementing the higher order scheme to support handling the unstructured mesh. The code is validated using the traditional shock tube problem and the results are verified to be more accurate than the existing schemes in reference with the analytical result. The convection test is performed to compare the computational accuracy on convective transfer; it is found that the new scheme has less numerical diffusion compared to the existing schemes. A four valve pentroof engine, an example case of KIVA package is used as application to ensure the stability of the scheme in practical application. The results are compared for the temperature profile. In spite of all the positive results, the numerical scheme implemented has a downside of consuming more CPU time for the computational analysis. The detailed comparison is provided. However, in an overview, the implementation of the higher order scheme in the latest code KIVA 4 is verified to be successful and it gives better results than the existing scheme which satisfies the objective of this project.