Marskalk Bernadotte. Skildringar ur hans lif och hans tid (1763-1810).

Also published with title: Marskalk Bernadotte och hand tid. 1763-1810.

Gospel and human lif

Mode of access: Internet.

Enhanced information transmission with signal dependent noise in an array of LIF neurons

Sensory cells usually transmit information to afferent neurons via chemical synapses, in which the level of noise is dependent on an applied stimulus. Taking into account such dependence, we model a sensory system as an array of LIF neurons with a common signal. We show that information transmission is enhanced by a nonzero level of noise. Moreover, we demonstrate a phenomenon similar to suprathreshold stochastic resonance with additive noise. We remark that many properties of information transmission found for the LIF neurons was predicted by us before with simple binary units [Phys. Rev. E 75, 021121 (2007)]. This confirmation of our predictions allows us to point out identical roots of the phenomena found in the simple threshold systems and more complex LIF neurons.

GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors

Leukemia inhibitory factor (LIF) and its receptor (LIFR) are "twins" of Oncostatin M (OSM) and OSMR, respectively, likely having arisen through gene duplications. We compared their effects in a bone nodule-forming model of in vitro osteogenesis, rat calvaria (RC) cell cultures. Using a dominant-negative LIF mutant (hLIF-05), we showed that in RC cell cultures mouse OSM (mOSM) activates exclusively glycoprotein 130 (gp130)/OSMR. In treatments starting at early nodule formation stage, LIF, mOSM, IL-11, and IL-6 + sIL-6R inhibit bone nodule formation, that is, osteoprogenitor differentiation. Treatment with mOSM, and no other cytokine of the family, in early cultures (day 1-3 or 1-4) increases bone colony numbers. hLIF-05 also dose dependently stimulates bone nodule formation, confirming the inhibitory action of gp130/LIFR on osteogenesis. In pulse treatments at successive stages of bone nodule formation and maturation, LIF blocks osteocalcin (OCN) expression by differentiated osteoblasts, but has no effect on bonesialoprotein (BSP) expression. Mouse OSM inhibits OCN and BSP expression in preconfluent cultures with no or progressively reduced effects at later stages, reflecting the disruption of early nodules, possibly due to the strong apoptotic action of mOSM in RC cell cultures. In summary, LIFR and OSMR display differential effects on differentiation and phenotypic expression of osteogenic cells, most likely through different signal transduction pathways. In particular, gp130/OSMR is the only receptor complex of the family to stimulate osteoprogenitor differentiation in the RC cell culture model. © 2005 Wiley-Liss, Inc.

Electrochemical formation of ordered pore arrays in InP in KCl

Pores are formed electrochemically in n-InP in KCl electrolytes with concentrations of 2 mol dm-3 or greater. The pore morphology is similar to what is seen in other halide-based electrolytes. At low potentials, crystallographically oriented (CO) pores are formed. At higher potentials, current-line oriented (CLO) pores are formed. Crystallographically oriented pore walls are observed for both pore morphologies. When formed at a constant current, potential oscillations are observed which have been correlated to oscillations in the pore width. The CLO pore wall smoothness and overall uniformity increase as KCl concentration is increased. The porous structures formed in KCl compare favourably with those formed in the more acidic or alkaline electrolytes that are typically used to form these structures.

Contribuicao ao conhecimento dos efeitos da radiacao em cristais de KCl com impurezas de Sr

Tese (Doutoramento)