Lettres de L.B. Lauraguais à Madame dans lesquelles on trouve des jugemens sur quelques ouvrages; la vie de l'Abbe de Voisenon; une conversation de Champfort sur l'Abbe Syeyes, et un fragment historique des Mémoires de Madame de Brancas sur Louis XV, et Madame de Chateauroux.

Mode of access: Internet.

Clef du grand œuvre, ou lettres du Sancelrien Tourangeau, a Madame L.D.L.B***. T.D.F.A.T. [Madame le Febvre de la Borde, Trésorière de France à Tours] : Dans la premiere ... la matiere des sages. Dans la seconde, les vertus ... de l'elexir [sic] blanc et rouge ... Dans la troisieme ... sera prouvé la réalité du grand œuvre.

The attribution to Cailleau is by Barbier. A note in the de Guaita copy assigns the work to J.J. Coullon.

Œuvres choisies de L. B. Picard.

La manie de briller, comédie.--Vanglas, ou Les anciens amis, comédie.--Une matinée de Henri IV, comédie.-- Le susceptible.

Lettres de M.L.B.D.B. a M.P.L.G.H.D.L.S. a Marseille, sur l'existence du magnétisme animal, & l'agent universel de la nature, dont le docteur Mesmer se sert pour opérer ses guérisons : où l'on prouve que l'un & l'autre ont été soupçonnés par les anciens philosophes ... : pour servir de réponse à tout ce qu'on a pu dire & écrire contre le docteur Mesmer & ses principes ... /

Author identified in Barbier as: le baron de Bormeo [i.e. Bormes].

Frank B. Kellogg and American foreign relations, 1925-1929.

Mode of access: Internet.

City ways and company streets,

Poems reprinted in part from various periodicals.

Jimmy and Nelson, 670th Camp Bitely, F-22, Bitely Michigan

[Two young men in CCC work attire sit together]

Hugonis Grotii de jure belli ac pacis libri tres : cum annotatis auctoris, nec non J. F. Gronovii notis, & J. Barbeyracii animadversionibus, commentariis insuper locupletissimis Henr. l.b. de Cocceii ... sub titulo Grotii illustrati antea editis, nunc ad calcem cujusque capitis adjectis : insertis quoque observationibus Samuelis l.b. de Cocceii ... : adduntur tandem ipsius Grotii Dissertatio de mari libero, ac Libellus singularis de aequitate, indulgentia et facilitate.

Vols. 2 and 4 have at end Bibliopolae monitum = Avis du libraire, about pricing in various European currencies in 1751 and 1752.

L.R.A. triennial index digest, 1915-1917 combining notes and cases in one alphabetical arrangement, and supplementing digests 1-70 L.R.A. and 1-52 L.R.A. (N.S.) and indexes to notes 1 L.R.A.-42 L.R.A. (N.S.) and 43 L.R.A. (N.S.)-L.R.R. 1916 F.

Mode of access: Internet.

The flora of Rensselaer county, New York. A record of the phenogams and vascular eryptogams growing in said district, independent of cultivation.

Mode of access: Internet.

Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture

1 Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) have structural similarities, interact with each others receptors (calcitonin receptor-like receptor (CLR)/receptor-activity-modifying proteins (RAMPs)) and show overlapping biological activities. AM and CGRP receptors are chiefly coupled to cAMP production. In this study, a method of primary dissociated cell culture was used to investigate the presence of AM and CGRP receptors and their effects on cAMP production in embryonic spinal cord cells. 2 Both neuronal and non-neuronal CLR immunopositive cells were present in our model. 3 High affinity, specific [ 125I]-AM binding sites (K(d) 79±9 pM and B(max) 571±34 fmol mg -1 protein) were more abundant than specific [ 125I]-CGRP binding sites (K(d) 12±0.7 pM and B(max) 32±2 fmol mg -1 protein) in embryonic spinal cord cells. 4 Specific [ 125I]-AM binding was competed by related molecules with a ligand selectivity profile of rAM>hAM(22-52)>rCGRPα>CGRP(8-37) ≫[r-(r*,s*)]-N-[2-[[5-amino-1-[[4-(4-pyridinyl)-1-piperazinyl] carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1, 4-dihydro-2-oxo-3(2H)-quinazolinyl)-,1-piperidinecarboxamide (BIBN4096BS). 5 Specific [ 125I]-CGRP binding was competed by rCGRPα>rAM≥ CGRP(8-37)≥BIBN4096BS>hAM(22-52). 6 Cellular levels of cAMP were increased by AM (pEC"5"0 10.2±0.2) and less potently by rCGRPα (pEC"5"0 8.9±0.4). rCGRPα-induced cAMP accumulation was effectively inhibited by CGRP(8-37) (pA"2 7.63±0.44) and hAM(22-52) (pA"2 6.18±0.21) while AM-stimulation of cAMP levels was inhibited by CGRP(8-37) (pA"2 7.41±0.15) and AM(22-52) (pA"2 7.26±0.18). BIBN4096BS only antagonized the effects of CGRP (pA"2 8.40±0.30) on cAMP accumulation. 7 These pharmacological profiles suggest that effects of CGRP are mediated by the CGRP"1 (CLR/RAMP1) receptor in our model while those of AM are related to the activation of the AM"1 (CLR/RAMP2) receptor subtype. © 2006 Nature Publishing Group All rights reserved.

Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

Most of the gemcitabine (dFdC) resistant cell lines manifested high NF?B activity. The NF?B activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of disulfiram (DS), an anti-alcoholism drug and NF?B inhibitor, and copper (Cu) on the chemoresistant cell lines was examined. The DS/Cu complex significantly enhanced the cytotoxicity of dFdC (resistant cells: 12.2–1085-fold) and completely reversed the dFdC resistance in the resitant cell lines. The dFdC-induced NF?B activity was markedly inhibited by DS/Cu complex. The data from this study indicated that DS may be used in clinic to improve the therapeutic effect of dFdC in breast and colon cancer patients.

Piano recital consisting of works by J. S. Bach, L. Van Beethoven and F. Chopin with extended program notes

Partita No 4 in D Major, BWV 828 - Johann Sebastian Bach (1685-1750) Sonata No 23 in F minor, Op 57 - Ludwig van Beethoven (1770-1827) Scherzo No 1 in B minor, Op 20 - Frederic Chopin (1810-1849)

EXAMINATION OF VALPROIC ACID-INDUCED PERTURBATIONS TO DNA REPAIR, NF-ΚB SIGNALING AND CBP/P300 TRANSCRIPTIONAL CO-ACTIVATORS

Exposure to the antiepileptic drug valproic acid (VPA) is associated with an increased risk of congenital malformations including heart, skeletal and most frequently neural tube defects. Although the mechanisms contributing to its teratogenesis are not well understood, VPA was previously shown to increase homologous recombination (HR)-mediated DNA repair and decrease protein expression of the transcription factor NF-κB/p65. The studies in this thesis utilized in vivo and in vitro models to evaluate the expression of HR mediators, investigate the implications of decreased p65 including DNA binding and transcriptional activation, and the expression and histone acetyltransferase activity of Cbp/p300 with an aim to provide mechanistic insight into VPA-mediated alterations. The first study demonstrated that following maternal administration of VPA, mouse embryonic mRNA expression of HR mediators Rad51, Brca1 and Brca2 exhibited temporal and tissue-specific alterations. Protein expression of Rad51 was similarly altered and preceded increased cleavage of caspase-3 and PARP; indicative of apoptosis. The second study confirms previous findings of decreased total cellular p65 protein using P19 cells, but is the first to demonstrate that nuclear p65 protein is unchanged. NF-κB DNA binding was decreased following VPA exposure and maybe mediated by decreased p50 protein, which dimerizes with p65 prior to DNA binding. Transcriptional activity of NF-κB was also increased with VPA exposure which was not due to increased p65 phosphorylation at Ser276. Furthermore, the transcriptional activation capacity was unaffected by VPA exposure as combined exposure to VPA and TNFα additively increased NF-κB activity. The third study demonstrated that VPA exposure in P19 cells decreased Cbp/p300 total cellular and nuclear protein attributed primarily to ubiquitin proteasome-mediated degradation. Histone acetyltransferase (HAT) activity of p300 was decreased proportionately to nuclear protein following VPA exposure. Inhibition of Cbp/p300 HAT activity decreased p65 total cellular protein, increased caspase-3 cleavage and ROS similar to VPA exposures. Furthermore, pre-treatment with the antioxidant enzyme catalase attenuated the increase in caspase-3 cleavage, but not p65 protein. Overall, this thesis demonstrates that VPA exposure impacts the expression and activity of the transcription factor NF-κB and transcriptional co-activators/HATs Cbp/p300, which has implications for downstream VPA targets including Rad51, Brca1 and Brca2.