Kim jestem? Kim się staję? Od praktyki do teorii

W artykule w zakresie metody teologiczno-fundamentalnej przedstawione zosta��y następujące główne zagadnienia. 1. Konspekt edukacyjno-psychologicznych warsztatów, 2. Uzasadnienie metodyczne i metodologiczne przyjętej konstrukcji. W konspekcie szczegółowo opisane zosta��y kolejne kroki, które powinien podjąć prowadzący z pewnymi sugestiami ku czemu dane dzia��ania prowadzą. Szerzej zosta��y podane wnioski, do których prowadzący powinien podprowadzić uczestników warsztatów w obszarze teologii fundamentalnej – jako pomoc w poszukiwaniach celu, ca��ości i sensu – wykorzystano elementy psychologii, filozofii, teologii duchowości. Procedura ćwiczeń przeprowadza uczestnika od pyta�� o samego siebie do pyta�� o siebie poprzez relacje z drugim, tak by uświadomić mu możliwość kontaktu z Drugim. W dalszej części przedstawienia opisano próbę odpowiedzi na pytanie „Co było potrzebne, od strony metody, by ten konspekt mógł powsta��?” Koniecznym było skonstruowanie swoistej metafory i opracowano narrację, które razem sta��y się hipotezą wyja��niającą obejmującą szerokie spektrum badanych relacji, pomiędzy konspektem i procesem jego powstawania a jego twórcą, procesem przeprowadzonych warsztatów a czytelnikiem, prowadzącym warsztaty a uczestnikiem. Na zakończenie przedstawiono ewaluację przeprowadzonych warsztatów.

Kim jestem? Kim się staję? W dialogicznym napięciu JA-TY. Źródła teoretyczne

W niniejszym artykule przedstawiono komponenty wchodzące w skład źródeł teoretycznych, będących podstawą powstania konspektu warsztatów. Treść artykułu nie wychodzi poza obszar metodologii teologicznej. Badania ukazujące przesłanki procesów zaaranżowanych w czasie warsztatów oraz podane wnioski końcowe wynikają z bada�� przeprowadzonych w polu analiz teologii fundamentalnej. Ta dziedzina teologiczna zakłada interdyscyplinarne łączenie metod i osiągnięć teologii i nauk antropologicznych. W kolejnych odsłonach ukazane zosta��y trzy aspekty odkrywania ludzkiego JA w dialogicznym napięciu z TY. Dzięki analizie transakcyjnej Erica Berne’a można ukaza��, przy pomocy prostych technik edukacyjnych, że człowiek w poznaniu siebie potrzebuje drugiego w ka��dym aspekcie swego istnienia. Tym, co umożliwia mu bycie z sobą i innymi do zdolność wczucia. Tę kategorię badawczą analizowa��a Edyta Stein jako podstawę realnych relacji JA-TY, gdzie poprzez TY może zosta�� określony sam człowiek jako nie-ja, inny, drugi, czy ostatecznie osobowy Bóg. Możliwość zastosowania procesów opartych na wczuciu w przestrzeni relacji wiary doprowadza ku teologii duchowości. W jej ramach wypracowany zosta�� model antropologiczny, który widzi człowieka w ciągłym stawaniu się wobec innych i Boga. Przyjęta do bada�� praktyczno-biblijna antropologia Ignacego Loyoli pozwala na uwiarygodnienie kroków podjętych w czasie warsztatów, tak by nie były manipulacją a służyły wolnemu wyborowi uczestników w świadomym poszukiwaniu sensu i celu istnienia.

La notion de l’explosion de la coopération et ses implications chez Kim Sterelny.

Le concept de coopération est souvent utilisé dans le domaine de l’éthique et de la politique pour illustrer et comprendre l’alignement des comportements associatifs entre les êtres humains. En lien avec ce concept, notre recherche portera sur la première question de savoir si Kim Sterelny (2003) réussit à produire un modèle théorique permettant d’expliquer les origines et les mécanismes de la coopération humaine. Notre recherche portera aussi sur la deuxième question de savoir s’il arrive à se servir de ce modèle pour infirmer la thèse de la modularité massive. Ainsi, ce mémoire traitera successivement du problème de la coopération, de la théorie de la sélection de groupe, du déclencheur écologique de la coopération des hominidés, des notions de coalition, d’exécution et d’engagement et finalement de la thèse de la modularité massive. Par l’examen de ces sujets, nous souhaitons démontrer que Sterelny n’arrive qu’à fournir une esquisse probable des origines et du développement de la coopération humaine et que sa critique de la thèse de la modularité massive n’arrive pas à infirmer cette dernière.

La notion de l’explosion de la coopération et ses implications chez Kim Sterelny

Le concept de coopération est souvent utilisé dans le domaine de l’éthique et de la politique pour illustrer et comprendre l’alignement des comportements associatifs entre les êtres humains. En lien avec ce concept, notre recherche portera sur la première question de savoir si Kim Sterelny (2003) réussit à produire un modèle théorique permettant d’expliquer les origines et les mécanismes de la coopération humaine. Notre recherche portera aussi sur la deuxième question de savoir s’il arrive à se servir de ce modèle pour infirmer la thèse de la modularité massive. Ainsi, ce mémoire traitera successivement du problème de la coopération, de la théorie de la sélection de groupe, du déclencheur écologique de la coopération des hominidés, des notions de coalition, d’exécution et d’engagement et finalement de la thèse de la modularité massive. Par l’examen de ces sujets, nous souhaitons démontrer que Sterelny n’arrive qu’à fournir une esquisse probable des origines et du développement de la coopération humaine et que sa critique de la thèse de la modularité massive n’arrive pas à infirmer cette dernière.

Multimodal Mri-based Study In Patients With Spg4 Mutations.

Mutations in the SPG4 gene (SPG4-HSP) are the most frequent cause of hereditary spastic paraplegia, but the extent of the neurodegeneration related to the disease is not yet known. Therefore, our objective is to identify regions of the central nervous system damaged in patients with SPG4-HSP using a multi-modal neuroimaging approach. In addition, we aimed to identify possible clinical correlates of such damage. Eleven patients (mean age 46.0 ± 15.0 years, 8 men) with molecular confirmation of hereditary spastic paraplegia, and 23 matched healthy controls (mean age 51.4 ± 14.1years, 17 men) underwent MRI scans in a 3T scanner. We used 3D T1 images to perform volumetric measurements of the brain and spinal cord. We then performed tract-based spatial statistics and tractography analyses of diffusion tensor images to assess microstructural integrity of white matter tracts. Disease severity was quantified with the Spastic Paraplegia Rating Scale. Correlations were then carried out between MRI metrics and clinical data. Volumetric analyses did not identify macroscopic abnormalities in the brain of hereditary spastic paraplegia patients. In contrast, we found extensive fractional anisotropy reduction in the corticospinal tracts, cingulate gyri and splenium of the corpus callosum. Spinal cord morphometry identified atrophy without flattening in the group of patients with hereditary spastic paraplegia. Fractional anisotropy of the corpus callosum and pyramidal tracts did correlate with disease severity. Hereditary spastic paraplegia is characterized by relative sparing of the cortical mantle and remarkable damage to the distal portions of the corticospinal tracts, extending into the spinal cord.

Theobromine Increases Nad⁺/sirt-1 Activity And Protects The Kidney Under Diabetic Conditions.

Reduction in sirtuin 1 (Sirt-1) is associated with extracellular matrix (ECM) accumulation in the diabetic kidney. Theobromine may reduce kidney ECM accumulation in diabetic rats. In the current study, we aimed to unravel, under diabetic conditions, the mechanism of kidney ECM accumulation induced by a reduction in Sirt-1 and the effect of theobromine in these events. In vitro, we used immortalized human mesangial cells (iHMCs) exposed to high glucose (HG; 30 mM), with or without small interfering RNA for NOX4 and Sirt-1. In vivo, spontaneously hypertensive rats (SHR) were rendered diabetic by means of streptozotocin and studied after 12 wk. The effects of treatment with theobromine were investigated under both conditions. HG leads to a decrease in Sirt-1 activity and NAD(+) levels in iHMCs. Sirt-1 activity could be reestablished by treatment with NAD(+), silencing NOX4, and poly (ADP-ribose) polymerase-1 (PARP-1) blockade, or with theobromine. HG also leads to a low AMP/ATP ratio, acetylation of SMAD3, and increased collagen IV, which is prevented by theobromine. Sirt-1 or AMPK blockade abolished these effects of theobromine. In diabetic SHR, theobromine prevented increases in albuminuria and kidney collagen IV, reduced AMPK, elevated NADPH oxidase activity and PARP-1, and reduced NAD(+) levels and Sirt-1 activity. These results suggest that in diabetes mellitus, Sirt-1 activity is reduced by PARP-1 activation and NAD(+) depletion due to low AMPK, which increases NOX4 expression, leading to ECM accumulation mediated by transforming growth factor (TGF)-β1 signaling. It is suggested that Sirt-1 activation by theobromine may have therapeutic potential for diabetic nephropathy.

A universidade sob a otica da extensão universitaria : analise da função extensão universitaria no pensamento do professor universitario de Educa��ão Fisica

Universidade Estadual de Campinas . Faculdade de Educa��ão Física

Educa��ão fisica e hegemonia

Universidade Estadual de Campinas . Faculdade de Educa��ão Física

Photodynamic inactivation of four Candida species induced by photogem®

This study evaluated the in vitro susceptibility of C. albicans, C. dubliniensis, C. tropicalis and C. krusei to photodynamic therapy (PDT) induced by Photogem® and light emitting diode (LED). Suspensions of each Candida strain were treated with three photosensitizer (PS) concentrations (10, 25 and 50 mg/L) and exposed to 18.0, 25.5 and 37.5 J/cm² LED light fluences (λ ~ 455 nm). Control suspensions were treated only with PS concentrations, only exposed to the LED light fluences or not exposed to LED light or PS. Sixteen experimental conditions were obtained and each condition was repeated three times. From each sample, serial dilutions were obtained and aliquots were plated on Sabouraud Dextrose Agar. After incubation of plates (37 ºC for 48 hours), colonies were counted (cfu/mL) and the data were statistically analyzed by ANOVA and the Tukey test (α=0.05). Complete killing of C. albicans was observed after 18.0 J/cm² in association with 50 mg/L of PS. C. dubliniensis were inactivated after 18.0 J/cm² using 25 mg/L of PS. The inactivation of C. tropicalis was observed after photosensitization with 25 mg/L and subsequent illumination at 25.5 J/cm². For C. krusei, none of the associations between PS and light resulted in complete killing of this species. PDT proved to be effective for the inactivation of C. albicans, C. dubliniensis and C. tropicalis. In addition, reduction in the viability of C. krusei was achieved with some of the PS and light associations.

Methodology of a nationwide cross-sectional survey of prevalence and epidemiological patterns of hepatitis A, B and C infection in Brazil

Um inquérito de base populacional foi conduzido na popula��ão urbana de todas as capitais e do Distrito Federal no Brasil para fornecer informa��ões sobre a prevalência de hepatites virais e fatores de risco, entre 2005 e 2009. Este artigo descreve o delineamento e a metodologia do estudo que envolveu a popula��ão com idade entre 5 e 19 anos para hepatite A e 10 a 69 anos para hepatite B e C. As entrevistas e amostras de sangue foram obtidas através de visitas domiciliares e a amostra selecionada a partir de uma amostragem estratificada em múltiplos estágios (por conglomerado) com igual probabilidade para cada domínio de estudo (região e faixa etária). Nacionalmente, 19.280 residências e ~31.000 indivíduos foram selecionados. O tamanho da amostra foi suficiente para detectar uma prevalência em torno de 0,1% e para avaliar os fatores de risco por região. A metodologia apresentou-se viável para distinguir entre diferentes padrões epidemiológicos da hepatite A, B e C. Estes dados serão de valia para a avalia��ão das políticas de vacina��ão e para o desenho de estratégias de controle.

The effects of the experimental infection from a focus of transmission of Schistosoma mansoni in a population of Biomphalaria tenagophila (D'Orbigny, 1835) in the region of "Vale do Ribeira de Iguape", Brazil

To observe the effects of the parasitic infection on the biology of B. tenagophila, field and laboratory populations of this mollusk from Itariri, in Vale do Ribeira, Brazil, were experimentally infected. Each mollusk received 10 miracidia of Schistosoma mansoni (SJ lineage) and was observed throughout the parasite's development. The biological variables were compared according to the criteria "group" and "infectious phase". The main damage caused by the parasitic infection manifested itself in reproduction, longevity and lesions on the shell of the mollusks in the patent phase. An infection rate of 58.8% was observed. Microanatomical study of the mollusk's digestive gland and ovotestis revealed the presence of evolving larval forms and cercariae. It was concluded that the effects of the parasitic infection on both populations were moderate, despite the low survival rate of the infected mollusks, the damage did not prevent either reproduction or the elimination of cercariae, which continued for a long time.

Promoção da sa��de e a forma��ão cidadã: a percepção do professor sobre cidadania

Vários movimentos internacionais, como o da Promoção da Sa��de, têm colocado o exercício da cidadania como estratégia de melhoria das condições de vida e sa��de da popula��ão de pa��ses em desenvolvimento. A educa��ão tem papel importante no desenvolvimento deste exercício, merecendo atenção especial a escola e o professor, por estar mais próximo do aluno. Assim, o objetivo deste estudo foi conhecer as representa��ões sociais do professor sobre cidadania, sobre o aluno ser cidadão, além de sua visão sobre o seu papel e o da escola no desenvolvimento dela. Foram entrevistados quarenta professores de escola pública da cidade de São Paulo, e seus discursos foram analisados pela metodologia do Discurso do Sujeito Coletivo (DSC). A maioria dos professores considera a escola como um espa��o onde a cidadania deve ser desenvolvida e com o professor tendo grande responsabilidade nesse desenvolvimento; sabe da importância de suas atitudes e ensino na forma��ão do aluno; reconhece o aluno como um futuro cidadão e percebe a cidadania como uma participa��ão ativa na sociedade, além dos direitos e deveres. Os professores revelaram algumas atitudes favoráveis ao desenvolvimento do exercício da cidadania, apontando para o alcance de melhores condições de sa��de e vida da popula��ão brasileira.

The effects of the experimental onfection from a focus of transmissopn of Schistosoma mansoni in a population of Biomphalaria tenagophila (D'Orbigny, 1835) in the region of "Vale do Ribeira de Iguape", Brazil

Com objetivo de observar os efeitos da infecção parasitária na biologia de B. tenagophila, foram realizadas infecções experimentais em popula��ões de campo e laboratório, ambas procedentes de Itariri, Vale do Ribeira, Brasil. Cada molusco recebeu 10 miracídios de Schistosoma mansoni (linhagem SJ), sendo observado durante o desenvolvimento dos parasitos. As variáveis biológicas foram comparadas segundo os critérios "grupo" e "fase de infecção". Os principais danos decorrentes do parasitismo se manifestaram na reprodução, na longevidade e em lesões na concha dos moluscos na fase patente. Foi encontrada uma taxa de infecção de 58,8 por cento. O estudo microanatômico da glândula digestiva e do ovoteste do molusco revelou a presença de formas larvárias em evolução e cercárias. Concluiu-se que os efeitos da infecção parasitária, sobre as duas popula��ões, foram moderados, uma vez que os danos não impediram a reprodução e a elimina��ão de cercárias que se manteve por um longo período, apesar da baixa sobrevivência dos moluscos parasitados