740 resultados para Katherine Parsons
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Includes index.
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Includes index.
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Mode of access: Internet.
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Mounted samples of colored paper on leaf 46.
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Only 100 copies run; this is copy 57.
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Mode of access: Internet.
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Mode of access: Internet.
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We have used microarray gene expression pro. ling and machine learning to predict the presence of BRAF mutations in a panel of 61 melanoma cell lines. The BRAF gene was found to be mutated in 42 samples (69%) and intragenic mutations of the NRAS gene were detected in seven samples (11%). No cell line carried mutations of both genes. Using support vector machines, we have built a classifier that differentiates between melanoma cell lines based on BRAF mutation status. As few as 83 genes are able to discriminate between BRAF mutant and BRAF wild-type samples with clear separation observed using hierarchical clustering. Multidimensional scaling was used to visualize the relationship between a BRAF mutation signature and that of a generalized mitogen-activated protein kinase ( MAPK) activation ( either BRAF or NRAS mutation) in the context of the discriminating gene list. We observed that samples carrying NRAS mutations lie somewhere between those with or without BRAF mutations. These observations suggest that there are gene-specific mutation signals in addition to a common MAPK activation that result from the pleiotropic effects of either BRAF or NRAS on other signaling pathways, leading to measurably different transcriptional changes.
Uma leitura de gênero nos contos "Prelúdio", "Na baía" e "A casa de bonecas", de Katherine Mansfield
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This work aims to analyze the short stories “Prelude”, “At the Bay” and “The Doll’s House”, by Katherine Mansfield under the prism of the gender studies (mainly on the works of Joan Scott and Elisabeth Badinter). To reach such objective, and based on the feminist criticism works (especially those of Elaine Showalter and Toril Moi), we analyzed the three stories, which are from the writer’s so-called “family phase”. The present work contains a bibliographical contextualization of Mansfield’s modernist work under three main aspects: modernism, the short story and women’s writing/writings on women. From the analysis of the three short stories, we observed that questions of gender, representation and identity were depicted by means of the preponderance of female characters from all ages, marital statuses and classes. At the end it was possible to verify how Mansfield works contributed to a reflection about places and roles occupied by women in turn of the XIX and XX Centuries, whereas how this author was also in search for her own identity as a woman and as a writer, exactly in a context when women writers and women’s writings started to become more visible face to a predominantly masculine literary canon.