University of South Carolina publications. Series 3. Biology. V.1 No.5

This publication is volume 1, issue 5 of the University of South Carolina Publications. Series III. Biology. on taxonomic studies of the flora and fauna of South Carolina.

University of South Carolina publications. Series 3. Biology. V.2 No.1

This publication is volume 2, issue 1 of the University of South Carolina Publications. Series III. Biology. on taxonomic studies of the flora and fauna of South Carolina.

University of South Carolina publications. Series 3. Biology. V.2 No.2

This publication is volume 2, issue 2 of the University of South Carolina Publications. Series III. Biology. on taxonomic studies of the flora and fauna of South Carolina.

University of South Carolina publications. Series 3. Biology. V.2 No.4

This publication is volume 2, issue 4 of the University of South Carolina Publications. Series III. Biology. on taxonomic studies of the flora and fauna of South Carolina.

University of South Carolina publications. Series 3. Biology. V.1 No.4

This publication is volume 1, issue 4 of the University of South Carolina Publications. Series III. Biology. on taxonomic studies of the flora and fauna of South Carolina.

University of South Carolina publications. Series 3. Biology. V.2 No.3

This publication is volume 2, issue 3 of the University of South Carolina Publications. Series III. Biology. on taxonomic studies of the flora and fauna of South Carolina.

University of South Carolina publications. Series 3. Biology. V.3 No.1

This publication is volume 3, issue 1 of the University of South Carolina Publications. Series III. Biology. on taxonomic studies of the flora and fauna of South Carolina.

Approach to site, C House, Cooparoo

Looking uphill towards house from road.

Vitamin B12 stalls the 80 S ribosomal complex on the hepatitis C internal ribosome entry site

The effect of cyanocobalamin (CNCbl, vitamin 1312) on hepatitis C virus internal ribosome entry site (HCV IRES)-dependent initiation of translation was studied by ribosomal toeprinting and sucrose gradient centrifugation analysis. These results suggested that CNCbl did not inhibit HCV IRES-dependent translation by a competitive binding mechanism. CNCbl allowed 80 S elongation complex formation on the mRNA, but stalled the initiation at that point, effectively trapping the 80 S ribosomal complexes on the HCV TRES. CNCbl had no effect on cap-dependent mRNA, consistent with the known mRNA specificity of this translational inhibitor. To help elucidate the mechanism, comparative data were collected for the well-characterised translation inhibitors cycloheximide and 5'-guanylyl-imidophosphate, Although CNCbl stalled HCV IRES-dependent translation at approximately the same step in initiation as cycloheximide, the mechanisms of these two inhibitors are distinct. (C) 2002 Elsevier Science Ltd. All rights reserved.

A copper protein and a cytochrome bind at the same site on bacterial cytochrome c peroxidase

Biochemistry, 2004, 43 (46), pp 14566–14576 DOI: 10.1021/bi0485833

Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma

It is well established that interleukin-6 (IL-6) is an essential growth factor for multiple myeloma (MM) and patients with increased IL-6 levels have a poor prognosis. In healthy subjects, the presence of the C allele at a polymorphic site (-174 G/C) of the IL-6 gene is related to low IL-6 levels. In view of the potential association of this particular polymorphism with IL-6 concentration, and the relevance of IL-6 in MM pathogenesis, the objective of the present study was to investigate the prevalence of IL-6 (-174 G/C) promoter polymorphism and its association with development of MM in Brazilian individuals. We investigated the prevalence of these alleles in 52 patients and 60 healthy subjects (matched by age, sex, and race) of a Brazilian population. Thirty patients were male (42.4%), 24 (46.2%) were white and the median age at diagnosis was 58.5 years (range: 28 to 84 years). To determine the IL-6 (-174 G/C) polymorphism, molecular analysis was performed by polymerase chain reaction followed by endonuclease restriction digestion. The genotype distributions observed in the group of patients were 4% CC, 42% GC and 54% GG. The C allele frequency was 0.25. These results were similar to the control group, suggesting no impact of this polymorphism on the susceptibility to MM.

Animadversiones de libris raris. Quarum partem priorem cons. ampl. fac. phil. Aboënsis praeside m. Henrico Gabriele Porthan, eloq. prof. reg. [et] ord. R. Acad. litt. hum. hist. [et] antiquitt. membro. Publico examini modeste submittit Petrus Johannes Alopaeus, Wiburgensis, in audit. maj. die XVI Jun. MDCCXCI, h. a. m. c

Painovuosi nimekkeestä.

Animadversiones de libris raris. Quarum partem posteriorem cons. ampl. fac. phil. Aboënsis praeside m. Henrico Gabriele Porthan, eloq. prof. reg. [et] ord. R. Acad. litt. hum. hist. [et] antiquitt. membro. Pro gradu publico examini modeste submittit Petrus Johannes Alopaeus, Wiburgensis, in audit. maj. die XVIII. Jun. MDCCXCII. h. a. m. c

Painovuosi nimekkeestä.