Public health impact of statin prescribing strategies based on jupiter

Texte intégral: http://www.springerlink.com/content/3q68180337551r47/fulltext.pdf

10-8-19, Deauville, [Jacques] Keyser [coureur à pied] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55416

Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.

Polysaccharide sidechains attached to proteins play important roles in cell-cell and receptor-ligand interactions. Variation in the carbohydrate component has been extensively studied for the iron transport protein transferrin, because serum levels of the transferrin isoforms asialotransferrin + disialotransferrin (carbohydrate-deficient transferrin, CDT) are used as biomarkers of excessive alcohol intake. We conducted a genome-wide association study to assess whether genetic factors affect CDT concentration in serum. CDT was measured in three population-based studies: one in Switzerland (CoLaus study, n = 5181) and two in Australia (n = 1509, n = 775). The first cohort was used as the discovery panel and the latter ones served as replication. Genome-wide single-nucleotide polymorphism (SNP) typing data were used to identify loci with significant associations with CDT as a percentage of total transferrin (CDT%). The top three SNPs in the discovery panel (rs2749097 near PGM1 on chromosome 1, and missense polymorphisms rs1049296, rs1799899 in TF on chromosome 3) were successfully replicated , yielding genome-wide significant combined association with CDT% (P = 1.9 × 10(-9), 4 × 10(-39), 5.5 × 10(-43), respectively) and explain 5.8% of the variation in CDT%. These allelic effects are postulated to be caused by variation in availability of glucose-1-phosphate as a precursor of the glycan (PGM1), and variation in transferrin (TF) structure.

Factum pour François de La Salle, sieur de Clochet, tant pour lui que pour Louis et Suzanne de La Salle, ses neveu et nièce mineurs, et Salomon de La Salle, sieur de Puyrichard,... tous lesdits de La Salle enfants et petits-enfants et héritiers de défunt Jacques de La Salle et de Françoise Penigaud, leur mère,... demandeurs en lettres de rescision du 4 juin 1631,... contre damoiselle Catherine Penigaud, veuve de Barthélemy de Pivert des Gittons, sieur de Chenay...

[Factum. La Salle, Jacques de (Héritiers). 1631?]

Deux livres des venins , ausquels il est amplement discouru des bestes venimeuses, thériaques, poisons & contre-poisons, par Jacques Grévin,... Ensemble les oeuvres de Nicandre,... traduictes en vers françois

Comprend : [Œuvres]

[Jacques] Brugnon [joueur de tennis du Sporting club de Paris, rue de Saussure] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57570

[Jacques] Brugnon, [Marcel] Dupont [joueurs de tennis du Sporting club de Paris, rue de Saussure] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57568