Asbestos induces nuclear factor kappa B (NF-kappa B) DNA-binding activity and NF-kappa B-dependent gene expression in tracheal epithelial cells.

Nuclear factor kappa B (NF-kappa B) is a transcription factor regulating expression of genes intrinsic to inflammation and cell proliferation--features of asbestos-associated diseases. In studies here, crocidolite asbestos caused protracted and dose-responsive increases in proteins binding to nuclear NF-kappa B-binding DNA elements in hamster tracheal epithelial (HTE) cells. This binding was modulated by cellular glutathione levels. Antibodies recognizing p65 and p50 protein members of the NF-kappa B family revealed these proteins in two of the DNA complexes. Transient transfection assays with a construct containing six NF-kappa B-binding DNA consensus sites linked to a luciferase reporter gene indicated that asbestos induced transcriptional activation of NF-kappa B-dependent genes, an observation that was confirmed by northern blot analyses for c-myc mRNA levels in HTE cells. Studies suggest that NF-kappa B induction by asbestos is a key event in regulation of multiple genes involved in the pathogenesis of asbestos-related lung cancers.

Oversight hearings on the Susan B. Anthony dollar coin and mint operations : hearings before the Subcommittee on Consumer Affairs and the Subcommittee on General Oversight and Renegotiation of the Committee on Banking, Finance, and Urban Affairs, House of Representatives, sixty-sixth Congress, first session, September 25 and 26, 1979.

"Serial 96-30."

In the matter of: public hearing before Special Industry Committee no. 41-B for the food and related products industry in Puerto Rico. September 11, 15, and 16, 1958 ... San Juan, Puerto Rico. Reporters: John F. Hrozencik [a [and] Genevieve Biolsi.

Maynard E. Pirsig, chairman.

Orbits of the double stars, A B of [Epsilon] Hydrae and ? 883, by the graphical method.

Type-written ms.

Concerto no. 6, in B flat, for violin and piano /

Acc. arr. for piano.

Availability and use of abandoned rights of way. Task 4: A. survey of federal programs. B. survey of state and local programs.

Transportation Department, Office of Environmental Affairs, Washington, D.C.

A.S.T.M. manual on presentation of data : including Supplement A ... Supplement B ... Tables of squares and square roots /

Manual "originally issued in 1933; two supplements covering additonal material ... issued separately in 1935 ... combining this material in one volume and amplifying certain sections of the text"--Fore. to second printing, March, 1937.

Concerto no. 3 (B minor) : for violin and piano, op. 61 /

Acc. originally for orchestra.

Philosophical miscellanies : translated from the French of Cousin, Jouffroy, and B. Constant. With introductory and critical notices. By George Ripley ...

Mode of access: Internet.

Digest of rulings on Chicago Joint Agreement between the B. of L.E. and the B. of L.F. and E.; to which are appended all joint rulings of the Chief Executives of the two brotherhoods. February 20, 1914 to May 11, 1916.

4 v. called "Books"

The A B C of cutting and making garments for everyday needs ... /

Mode of access: Internet.

Jno. B. : Jeffery's guide and directory to the opera houses, theatres, public halls, bill posters, etc. of the cities and towns of America.

Spine title: Guide to the opera houses and theaters of America.

Memoir of the Rev. Francis Hodgson, B. D., scholar, poet, and divine,

Mode of access: Internet.