Horacio : La determinación genérica y la inmortalidad inmanente

El tema de la inmortalidad en el aquende que el poeta obtiene con su poesía y la que confiere a los que canta, rehúye el ámbito estrecho de la musa pedestris y reclama un ritmo y una métrica distinta de la yámbica de los Epodos o del hexámetro coloquial y entrecortado de las Sátiras. Horacio encuentra en la métrica eolia, alcaica y sáfica, la conexión apropiada entre tópico y tipo de metro adecuada a sus Odas.

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

The immortalization of human cells is a critical step during tumorigenesis. In vitro, normal human somatic cells must overcome two proliferative blockades, senescence and crisis, to become immortal. Transformation with viral oncogenes extends the life span of human cells beyond senescence. Such transformed cells eventually succumb to crisis, a period of widespread cellular death that has been proposed to be the result of telomeric shortening. We now show that ectopic expression of the telomerase catalytic subunit (human telomerase reverse transcriptase or hTERT) and subsequent activation of telomerase can allow postsenescent cells to proliferate beyond crisis, the last known proliferative blockade to cellular immortality. Moreover, we demonstrate that alteration of the carboxyl terminus of human telomerase reverse transcriptase does not affect telomerase enzymatic activity but impedes the ability of this enzyme to maintain telomeres. Telomerase-positive cells expressing this mutant enzyme fail to undergo immortalization, further tightening the connection between telomere maintenance and immortalization.

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of divisions. This process, termed replicative senescence, is thought to be a tumor-suppressive mechanism and an underlying cause of aging. There is ample evidence that escape from senescence, or immortality, is important for malignant transformation. By contrast, the role of replicative senescence in organismic aging is controversial. Studies on cells cultured from donors of different ages, genetic backgrounds, or species suggest that senescence occurs in vivo and that organismic lifespan and cell replicative lifespan are under common genetic control. However, senescent cells cannot be distinguished from quiescent or terminally differentiated cells in tissues. Thus, evidence that senescent cells exist and accumulate with age in vivo is lacking. We show that several human cells express a beta-galactosidase, histochemically detectable at pH 6, upon senescence in culture. This marker was expressed by senescent, but not presenescent, fibroblasts and keratinocytes but was absent from quiescent fibroblasts and terminally differentiated keratinocytes. It was also absent from immortal cells but was induced by genetic manipulations that reversed immortality. In skin samples from human donors of different age, there was an age-dependent increase in this marker in dermal fibroblasts and epidermal keratinocytes. This marker provides in situ evidence that senescent cells may exist and accumulate with age in vivo.

Short nomenclator or vocabular in English and Hebrew: composed alphabetically for the use and benefit of my pupils in particular and for the advantage of those who are desirous to obtain the knowledge of the Hebrew tongue in general, which may be that great help to understand not only ye sacred oracles in their original, but even any Jewish author (so far as concern owns) as also it may give great insight in ye tongue to those, as to compose it, a work altogether new, [ca. 1735]

Headed on the first page with the words "Nomenclatura hebraica," this handwritten volume is a vocabulary with the Hebrew word in the left column, and the English translation on the right. While the book is arranged in sections by letter, individual entries do not appear in strict alphabetical order. The small vocabulary varies greatly and includes entries like enigma, excommunication, and martyr, as well as cucumber and maggot. There are translations of the astrological signs at the end of the volume. Poem written at the bottom of the last page in different hand: "Women when good the best of saints/ that bright seraphick lovely/ she, who nothing of an angel/ wants but truth & immortality./ Verse 2: Who silken limbs & charming/ face. Keeps nature warm."

Commonplace book of Nathaniel Freeman, 1786-1787

Nathaniel Freeman made entries in this commonplace book between 1786 and 1787, while he was an undergraduate at Harvard College. The book includes the notes Freeman took during three of Hollis Professor Samuel Williams' "Course of Experimental Lectures," and cover Williams' lectures on "The Nature & Properties of Matter," "Attraction & Repulsion," and "The Nature, Kind, & Affections [?] of Motion." These notes also include one diagram. The book also includes forensic compositions on the subjects of capital punishment, the probability of "the immortality of the soul," and "whether there be any disinterested benevolence." It also includes a poem Freeman composed for his uncle, Edmund Freeman; an anecdote about Philojocus and Gripus; an essay called "Character"; a draft of a letter to the Harvard Corporation requesting that, in light of the public debt, the Commencement ceremonies be held privately to lower expenses and exhibit the merits of economy; and an "epistle" to his father, requesting money. This epistle begins: "Most honored sire, / Thy son, poor Nat, in humble strains, / Impell'd by want, thy generous bounty claims."

Sämmtliche Werke.

Vol. 1. Erläuterungen und Ergänzungen zum Wesen des Christenthums.- Vol. 2. Philosophische Kritiken und Grundsätze.- Vol. 3. Gedanken über Tod und Unsterblichkeit.- Vol. 4. Geschichte der neuern Philosophie von Bacon von Verulam bis Benedict Spinoza.- Vol. 5. Darstellung, Entwicklung und Kritik der Leibnitz'schen Philosophie.- Vol. 6. Pierre Bayle, ein Beitrag zur Geschichte der Philosophie und Menschheit.- Vol. 7. Das Wesen des Christenthums.- Vol. 8. Vorlesungen über das wesen der Religion.- Vol. 9. Theogonie nachder Quellen des classisischen, hebräischen und christlichen Alterthums.- Vol. 10. Gottheit, Freiheit und Unsterblichkeit vom Standpunkte der Anthropologie.

La fin du mal, ou l'immortalité des justes et l'anéantissement graduel des impénitents /

Includes bibliographical references (p. [195]-208).

Ploughshare and pruning-hook; ten lectures on social subjects,

Great possessions. - Crime and punishment. - Christianity a danger to the state. - The salt of the earth. - The rights of majorities. - Discreditable conduct. - What is womanly? - Use and ornament. - Art and Citizenship. - Conscious and unconscious immortality.

Pedon : hu sefer hasharat ha-nefesh /

Mode of access: Internet.

Juvenilia: being a second series of essays on sundry Æsthetical questions,

v. 1. Introduction: Juvenilia. The lake of Charlemagne. Botticelli at the Villa Lemmi. Rococo. Prosaic music and poetic music. Apollo the fiddler.--v. 2. The immortality of the Maestro Galuppi. Perigot. Lombard colour studies. Don Juan (con Stenterello) Signor Curiazio. Christkindchen. Epilogue.

The Queens : being passages from the lives of Elizabeth, queen of England, and Mary, queen of Scotland /

At head of title: "The first proofs," with words in an unknown alphabet. "We claim that this literary work is of the same mind that formerly composed and wrote the immortal works now known as those of William Shakespeare. Our Brotherhood has collected the most remote history of the world in the highest spiritual study, to satisfy the truth of immortality."--Introduction (translated.).

Platōnos phaidōn. Platonis Phaedo,

Stallbaum is the "editor germanus". cf. W. Engelmann, Bibliotheca scriptorum classicorum, 1880.

The progress of the intellect : as exemplified in the religious development of the Greeks and Hebrews /

Includes bibliographical references.

In Cambridge backs : being the vacation thoughts of a schoolmistress /

In Cambridge backs -- Friendship -- The new school mistress -- The artist -- The artistic temperament -- On the criticism of others -- The first great commandment -- Immortality -- On the writing of history.

Psychical research and survival,

Mode of access: Internet.