973 resultados para Hulke, Scott


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Scott Joplin’s (1867–1917) opera Treemonisha is the only opera in existence about the Reconstruction era African-American experience written by a black man who actually lived through it. This fact alone makes the opera a work of tremendous significance. Further, Joplin’s music is profoundly expressive and as stylistically unique as anything ever created in America. Through his score and libretto, Joplin vividly documented a culture that has left us few other artifacts: The echoes of the “field hollers,” spirituals, fiddle tunes, revival hymns, and ancient African dances of his rural childhood are all heard, along with the dialects of his people rising up from slavery. Yet for all of its obvious significance, Treemonisha has been a deeply misunderstood work. The opera was complex and virtually unprecedented, two reasons why 1910s America could not embrace it. And tragically, Joplin's original 1911 materials for the opera were almost entirely destroyed in the early 1960s. In the early 1970s several attempts were made to reconstruct it, but for the most part these were not concerned with the opera’s cultural origins or historic authenticity. But now, on the centennial of this extraordinary creation, comes this new recording of a completely authentic reconstruction of Treemonisha by Rick Benjamin, based on eighteen years of research.

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Faciogenital dysplasia or Aarskog-Scott syndrome (AAS) is an X-linked disorder characterized by craniofacial, skeletal, and urogenital malformations and short stature. Mutations in the only known causative gene FGD1 are found in about one-fifth of the cases with the clinical diagnosis of AAS. FGD1 is a guanine nucleotide exchange factor (GEF) that specifically activates the Rho GTPase Cdc42 via its RhoGEF domain. The Cdc42 pathway is involved in skeletal formation and multiple aspects of neuronal development. We describe a boy with typical AAS and, in addition, unilateral focal polymicrogyria (PMG), a feature hitherto unreported in AAS. Sequencing of the FGD1 gene in the index case and his mother revealed the presence of a novel mutation (1396A>G; M466V), located in the evolutionary conserved alpha-helix 4 of the RhoGEF domain. M466V was not found in healthy family members, in >300 healthy controls and AAS patients, and has not been reported in the literature or mutation databases to date, indicating that this novel missense mutation causes AAS, and possibly PMG. Brain cortex malformations such as PMG could be initiated by mutations in the evolutionary conserved RhoGEF domain of FGD1, by perturbing the signaling via Rho GTPases such as Cdc42 known to cause brain malformation.

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In Fraktur

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Signatur des Originals: S 36/F01826

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Signatur des Originals: S 36/G04197

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neu übers. von Friedrich Funck

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Fil: Bonilla, Manuel. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

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Este artículo se propone analizar la noción de experiencia presente en la obra de la historiadora feminista norteamericana Joan W. Scott. Se realiza un recorrido por las conceptualizaciones de dicha noción utilizadas en la Historia Social de los años sesenta, setenta y ochenta con las cuales Scott ha tenido importantes diálogos y discusiones. Por último, se presentan algunas críticas y limitaciones que, tanto desde la historia con perspectiva de género como desde la teoría feminista, se han señalado sobre el concepto de experiencia desarrollada por Scott

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Fil: Vicente, María Eugenia. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

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Este artículo se propone analizar la noción de experiencia presente en la obra de la historiadora feminista norteamericana Joan W. Scott. Se realiza un recorrido por las conceptualizaciones de dicha noción utilizadas en la Historia Social de los años sesenta, setenta y ochenta con las cuales Scott ha tenido importantes diálogos y discusiones. Por último, se presentan algunas críticas y limitaciones que, tanto desde la historia con perspectiva de género como desde la teoría feminista, se han señalado sobre el concepto de experiencia desarrollada por Scott

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Fil: Vicente, María Eugenia. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

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Fil: Bonilla, Manuel. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.