Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.

MultiCampus Open Educational Resources : the case of OER-HE

In this paper we address the implementation strategies regarding Open Educational Resources within a multicampus setting. A comparison is made between 3 institutions that are taking a very different approach: K.U.Leuven, which is a traditional university, the Open Universiteit (Netherlands) which is in the process of starting up the Network Open Polytechnics, and the Universitat Oberta de Catalunya. We are looking deeper into the pedagogical and organizational issues involved in implementing an OER strategy and show how OER holds the promise of flexible solutions for reaching at first sight very divergent goals.

Messiah : He shall feed his flock

r1941.

Messiah : He was despised and rejected

r1941.

Sinkkunaiset - keitä he ovat?

Kirjallisuusarvostelu

Ikinaiset, keitä varten he ovat?

Kirjallisuusarvostelu

Kun he palaavat

12 x 18 cm

Kun he palaavat

12 x 18 cm

Mappe-Monde, ou, Carte générale du globe terrestre representée en deux plan-hémispheres reveiie et changée en plusieurs endroits suivant les rélations les plus récentes

Julkaisussa: Cartes générales de la géographie ancienne et nouvelle, ou les empires, monarchies, royaumes, estats, républiques, et peuples. Vol I

L' hémisphère méridional pour voir plus distinctement les terres australes où se voyent les nouvelles découvertes faites en 1739 au sud du Cap de Bonne Esperance = waar in aangetoont werd de nieuwe ontdekkingen gedaam in t'jaar 1739 bezuiden de Caap de Goede Hoop

Lisäkartta: Plan et vue des terres du Cap de la Circoncision situé à 54 degrées de lat. méridiole et environ à 28 deg. 30 min. de longitude = Plan et gezigt van de landen van de Caap der Besnydenis gelegen op 54 gr. zuider br. en omtrent op 28 gr. 30 min. - Eteläisen pallonpuoliskon halkaisija 44,6 cm

Influence of He-Ne laser therapy on the dynamics of wound healing in mice treated with anti-inflammatory drugs

We determined the effects of helium-neon (He-Ne) laser irradiation on wound healing dynamics in mice treated with steroidal and non-steroidal anti-inflammatory agents. Male albino mice, 28-32 g, were randomized into 6 groups of 6 animals each: control (C), He-Ne laser (L), dexamethasone (D), D + L, celecoxib (X), and X + L. D and X were injected im at doses of 5 and 22 mg/kg, respectively, 24 h before the experiment. A 1-cm long surgical wound was made with a scalpel on the abdomens of the mice. Animals from groups L, D + L and X + L were exposed to 4 J (cm²)-1 day-1 of He-Ne laser for 12 s and were sacrificed on days 1, 2, or 3 after the procedure, when skin samples were taken for histological examination. A significant increase of collagen synthesis was observed in group L compared with C (168 ± 20 vs 63 ± 8 mm²). The basal cellularity values on day 1 were: C = 763 ± 47, L = 1116 ± 85, D = 376 ± 24, D + L = 698 ± 31, X = 453 ± 29, X + L = 639 ± 32 U/mm². These data show that application of L increases while D and X decrease the inflammatory cellularity compared with C. They also show that L restores the diminished cellularity induced by the anti-inflammatory drugs. We suggest that He-Ne laser promotes collagen formation and restores the baseline cellularity after pharmacological inhibition, indicating new perspectives for laser therapy aiming to increase the healing process when anti-inflammatory drugs are used.