No evidence for an association of posttraumatic stress disorder with circulating levels of CRP and IL-18 in a population-based study.

Several studies have shown associations of posttraumatic stress disorder (PTSD) with the development of cardiometabolic diseases. The underlying psychopathological mechanisms, including potential links to inflammatory processes, have been discussed but remain elusive. Therefore, the aim of the present study was to evaluate the association of PTSD symptoms with the inflammatory biomarkers C-reactive protein (CRP) and interleukin-18 (IL-18). The study population consisted of 3012 participants aged 32-81years drawn from the population-based KORA F4 study conducted in 2006-08 in the Augsburg region (Southern Germany). PTSD symptoms were measured by the Impact of Event Scale, the Posttraumatic Diagnostic Scale and interview data and classified as no, partial or full PTSD. The associations of PTSD with CRP and IL-18 concentrations were estimated by multiple regression analyses with adjustments for age, sex and cardiometabolic risk factors. Linear regression analyses showed no significant association between PTSD and CRP or IL-18 concentration: adjusted for age and sex, the geometric mean concentrations in participants with full PTSD was for CRP 9% lower and for IL-18 1% higher than in participants with no PTSD (p values 0.53 and 0.89). However, further analyses indicated that individuals with partial PTSD had an increased chance of belonging to the highest quartile of the IL-18 concentration. No significant association was observed for any of the three subscales intrusion, avoidance or hyperarousal with CRP or IL-18 concentration. This large, population-based study could not find an association of full PTSD with CRP and IL-18 concentrations. Further research is needed to analyse these relationships.

Das jüdische Unterrichtswesen während der spanisch-arabischen Periode : nebst hs. arab. u. hebr. Beil.

von M. Güdemann

Mus Hs Opern 381 (7) - Don Juan : eine komische Oper ; nach dem italienischen frey bearbeitet ; in zwey Aufzügen

nach der Musik des ... Mozard

Geschichte der Juden in Cöln und Umgebung : aus ältester Zeit bis auf die Gegenwart ; nach hs. u. gedr. Quellen bearb.

von Carl Brisch

Der Tanz zum Tode : eine wahre Geschichte nach den hs. Mittheilungen eines Zeitgenossen

erz. von E. Carmoly

Der Kampf der Juden um ihre Emanzipation in Bayern : auf Grund hs. Quellenmaterials

von A. Eckstein

Die Juden unter den Braunschweigischen Herzögen Julius und Heinrich Julius : nach hs. Quellen dargest.

von M. Wiener

Mus Hs 750/3 - No. 1

[Carl Oestreich]

Mus Hs 750/4 - Horn=musik : für Parsetthorn, 3 Horn, Trombone basso, Flauto ; desgleichen Trio-, Quartett

[Carl Oestreich]

Mus Hs 750/6 - Scherzando

[Carl Oestreich]

Mus Hs 750/7 - No. 1

[Carl Oestreich]

Mus Hs 750/9 - Allegretto scherzando

[Carl Oestreich]

Mus Hs 750/10 - Jaegerchor

[Carl Oestreich]

Mus Hs 771 - No 1.: während der Reise : im Auftrag S:. Ehrw:. M: v.: St. componirte ich diese zwei Lieder zum 2ten Grad um, und [unleserlich] führte selbige den 27ten August 5830 [!], zum erstenmale aus. in [Stein als ein Symbol für Freimaurerei] Socrates

[Carl Oestreich]

Serum ficolin-2 correlates worse than fecal calprotectin and CRP with endoscopic Crohn's disease activity.

BACKGROUND AND AIMS Ficolin-2 is an acute phase reactant produced by the liver and targeted to recognize N-acetyl-glucosamine which is present in bacterial and fungal cell walls. We recently showed that ficolin-2 serum levels were significantly higher in CD patients compared to healthy controls. We aimed to evaluate serum ficolin-2 concentrations in CD patients regarding their correlation with endoscopic severity and to compare them with clinical activity, fecal calprotectin, and CRP. METHODS Patients provided fecal and blood samples before undergoing ileo-colonoscopy. Disease activity was scored clinically according to the Harvey-Bradshaw Index (HBI) and endoscopically according to the simplified endoscopic score for CD (SES-CD). Ficolin-2 serum levels and fecal calprotectin levels were measured by ELISA. RESULTS A total of 136 CD patients were prospectively included (mean age at inclusion 41.5±15.4 years, 37.5% females). Median HBI was 3 [2-6] points, median SES-CD was 5 [2-8], median fecal calprotectin was 301 [120-703] μg/g, and median serum ficolin-2 was 2.69 [2.02-3.83] μg/mL. SES-CD correlated significantly with calprotectin (R=0.676, P<0.001), CRP (R=0.458, P<0.001), HBI (R=0.385, P<0.001), and serum ficolin-2 levels (R=0.171, P=0.047). Ficolin-2 levels were higher in CD patients with mild endoscopic disease compared to patients in endoscopic remission (P=0.015) but no difference was found between patients with mild, moderate, and severe endoscopic disease. CONCLUSIONS Ficolin-2 serum levels correlate worse with endoscopic CD activity when compared to fecal calprotectin or CRP.