940 resultados para Holm Steinhafel, Courtney
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In the metabolic syndrome, glucocorticoid activity is increased, but circulating levels show little change. Most of blood glucocorticoids are bound to corticosteroid-binding globulin (CBG), which liver expression and circulating levels are higher in females than in males. Since blood hormones are also bound to blood cells, and the size of this compartment is considerable for androgens and estrogens, we analyzed whether sex or eating a cafeteria diet altered the compartmentation of corticosterone in rat blood. The main corticosterone compartment in rat blood is that specifically bound to plasma proteins, with smaller compartments bound to blood cells or free. Cafeteria diet increased the expression of liver CBG gene, binding plasma capacity and the proportion of blood cell-bound corticosterone. There were marked sex differences in blood corticosterone compartmentation in rats, which were unrelated to testosterone. The use of a monoclonal antibody ELISA and a polyclonal Western blot for plasma CBG compared with both specific plasma binding of corticosterone and CBG gene expression suggested the existence of different forms of CBG, with varying affinities for corticosterone in males and females, since ELISA data showed higher plasma CBG for males, but binding and Western blot analyses (plus liver gene expression) and higher physiological effectiveness for females. Good cross- reactivity to the antigen for polyclonal CBG antibody suggests that in all cases we were measuring CBG.The different immunoreactivity and binding affinity may help explain the marked sex-related differences in plasma hormone binding as sex-linked different proportions of CBG forms.
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Kirja-arvio
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At the beginning of the 1990s, the concept of "European integration" could still be said to be fairly unambiguous. Nowadays, it has become plural and complex almost to the point of unintelligibility. This is due, of course, to the internal differentiation of EU membership, with several Member States pulling out of key integrative projects such as establishing an area without frontiers, the "Schengen" area, and a common currency. But this is also due to the differentiated extension of key integrative projects to European non-EU countries - Schengen is again a case in point. Such processes of "integration without membership", the focus of the present publication, are acquiring an ever-growing topicality both in the political arena and in academia. International relations between the EU and its neighbouring countries are crucial for both, and their development through new agreements features prominently on the continent's political agenda. Over and above this aspect, the dissemination of EU values and standards beyond the Union's borders raises a whole host of theoretical and methodological questions, unsettling in some cases traditional conceptions of the autonomy and separation of national legal orders. This publication brings together the papers presented at the Integration without EU Membership workshop held in May 2008 at the EUI (Max Weber Programme and Department of Law). It aims to compare different models and experiences of integration between the EU, on the one hand, and those European countries that do not currently have an accession perspective on the other hand. In delimiting the geographical scope of the inquiry, so as to scale it down to manageable proportions, the guiding principles have been to include both the "Eastern" and "Western" neighbours of the EU, and to examine both structured frameworks of cooperation, such as the European Neighbourhood Policy and the European Economic Area, and bilateral relations developing on a more ad hoc basis. These principles are reflected in the arrangement of the papers, which consider in turn the positions of Ukraine, Russia, Norway, and Switzerland in European integration - current standing, perspectives for evolution, consequences in terms of the EU-ization of their respective legal orders1. These subjects are examined from several perspectives. We had the privilege of receiving contributions from leading practitioners and scholars from the countries concerned, from EU highranking officials, from prominent specialists in EU external relations law, and from young and talented researchers. We wish to thank them all here for their invaluable insights. We are moreover deeply indebted to Marise Cremona (EUI, Law Department, EUI) for her inspiring advice and encouragement, as well as to Ramon Marimon, Karin Tilmans, Lotte Holm, Alyson Price and Susan Garvin (Max Weber Programme, EUI) for their unflinching support throughout this project. A word is perhaps needed on the propriety and usefulness of the research concept embodied in this publication. Does it make sense to compare the integration models and experiences of countries as different as Norway, Russia, Switzerland, and Ukraine? Needless to say, this list of four evokes a staggering diversity of political, social, cultural, and economic conditions, and at least as great a diversity of approaches to European integration. Still, we would argue that such diversity only makes comparisons more meaningful. Indeed, while the particularities and idiosyncratic elements of each "model" of integration are fully displayed in the present volume, common themes and preoccupations run through the pages of every contribution: the difficulty in conceptualizing the finalité and essence of integration, which is evident in the EU today but which is greatly amplified for non-EU countries; the asymmetries and tradeoffs between integration and autonomy that are inherent in any attempt to participate in European integration from outside; the alteration of deeply seated legal concepts, and concepts about the law, that are already observable in the most integrated of the non-EU countries concerned. These issues are not transient or coincidental: they are inextricably bound up with the integration of non-EU countries in the EU project. By publishing this collection, we make no claim to have dealt with them in an exhaustive, still less in a definitive manner. Our ambition is more modest: to highlight the relevance of these themes, to place them more firmly on the scientific agenda, and to provide a stimulating basis for future research and reflection.
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Opinnäytetyömme tarkoituksena oli selvittää kuvantamisyksiköiden henkilöstöjen käsityksiä lähijohtamisesta. Tarkastelimme, toteutuuko oikeudenmukainen johtaminen tutkimuskohteina olevissa kahden kunnan erikois- ja perusterveydenhuollon kuvantamisyksiköissä. Yksityiskohtaisena tavoitteenamme oli tutkia, kuinka työn organisointi toteutuu ja käyttääkö esimies vuorovaikutuksen ja motivoinnin keinoja johtamisessa. Työmme liittyy Työn organisointi ja työnjako röntgenosastoilla -projektiin, joka on osa suurempaa hanketta nimeltä Työn organisointi ja työnjako terveydenhuollon erityisaloilla. Hankkeessa ovat mukana sekä Helsingin ammattikorkeakoulu Stadia että työelämän edustajia eri tahoilta. Tutkimissamme organisaatoissa tapahtuneet muutokset luovat uusia haasteita johtamiseen. Henkilöstön käsitykset lähijohtamisesta ovat tärkeä lähtökohta toiminnan kehittämiselle. Opinnäytetyömme oli kvantitatiivinen kyselytutkimus. Tutkimuksessa käytetyt kysymykset ja väittämät laadittiin Sirpa Syväsen (2003) väitöskirjan mittarin pohjalta. Johtamista käsitteleviä väittämiä koko mittarissa oli neljätoista kappaletta. Kysely suoritettiin Internetin avulla ja se oli suunnattu kaikille kuvantamisyksiköiden työntekijöille, joita oli yhteensä 169. Kyselyyn vastasi 97 henkilöä ja vastausaktiivisuudeksi muodostui 57 %. Tarkastelimme tuloksia tutkimusongelmittain. Näiden lisäksi erikoissairaanhoidon ja perusterveydenhuollon sekä ammattiryhmien tulokset on esitetty väittämäkohtaisesti. Kokonaistuloksia katsottaessa oikeudenmukainen johtaminen toteutuu kummassakin kuvantamisyksikössä. Työn organisoinnin osalta tuloksissa ei näkynyt suurta eroa kuvantamisyksiköiden välillä. Vastaajat kokivat, että esimies tuntee hyvin heidän työtehtävänsä. Vuorovaikutuksen osalta koettiin asioiden olevan hyvin kuvantamisyksiköissä. Esimies luottaa työntekijöihinsä ja keskustelee sekä kertoo avoimesti työpaikan asioista.Vastaajat kokivat kummassakin kuvantamisyksiköissä, että esimies käyttää runsaasti motivoinnin keinoja johtamisessaan. Erityisesti opiskelemiseen ja työssä kehittymiseen koettiin saatavan runsaasti kannustusta. Ammattiryhmien tuloksia tarkateltaessa nousi esiin, että radiologit ja osastonhoitajat olivat muita tyytyväisimpiä kaikilla oikeudenmukaisen johtamisen osa-alueilla. Työmme tuloksia voidaan hyödyntää tutkimuskohteissamme toiminnan kehittämisessä. Jatkossa olisi mielenkiintoista selvittää esimerkiksi johtamistavan vaikutusta henkilöstön sairauspoissaoloihin. Avainsanat kuvantamisyksikkö, henkilöstö, lähijohtaminen, oikeudenmukainen johtaminen
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We examined root morphological and functional differences caused by restrictions imposed to vertical growth in the root system of holm oak (Quercus ilex L.) seedlings to assess the consequences of using nursery containers in the development of a confined root system for this species. Thus, root morphological, topological and functional parameters, including hydraulic conductance per leaf unit surface area (K $_{\rm RL})$, were investigated in one-year seedlings cultivated in three PVC tubes differing in length (20, 60 and 100 cm). Longer tubes showed greater projected root area, root volume, total and fine root lengths, specific root length (SRL) and K$_{\rm RL}$ values than did shorter tubes. On the other hand, the length of coarse roots (diameter > 4.5 mm) and the average root diameter were greater in shorter tubes. The strong positive correlation found between K$_{\rm RL}$ and SRL (r=+0.69; P<0.001) indicated that root thickness was inversely related to water flow through the root system. We concluded that root systems developed in longer tubes are more efficient for plant water uptake and, therefore, changes in root pattern produced in standard forest containers (i.e. about 20 cm length) may in fact prevent a proper establishment of the holm oak in the field, particularly in xeric environments.
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Helsingfors : K.E. Holm 1885, A. Weger
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Helsingfors : K.E. Holm 1885, A. Weger
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Helsingfors : K. E. Holm 1885, A. Weger
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Helsingfors : K.E. Holm 1885, A. Weger
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Helsingfors : K. E. Holm 1885, A. Weger
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Helsingfors : K. E. Holm 1885
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Thomas Campanius Holmin (1670-1702) teos on ensimmäinen ruotsiksi ilmestynyt kuvaus Pohjois-Amerikasta. Holm ei koskaan itse käynyt Amerikassa, vaan kirjoitti kuvauksen sukulaistensa ja muiden henkilöiden kertomusten ja muistiinpanojen pohjalta. Teos kertoo ruotsalaisen siirtokunnan muodostamisesta Delawareen, Pennsylvaniaan 1600-luvun alkupuolelta lähtien, sekä kuvaa paikallisten alkuasukkaiden kieltä ja kulttuuria. Se sisältää myös tietoja varhaisimmasta suomalaisasutuksesta Pohjois-Amerikassa. Teoksessa on kahdeksan kauniisti käsin väritettyä kuvaa ja karttaa. Teos kuuluu A. E. Nordenskiöldin kartografiseen ja maantieteelliseen kokoelmaan, joka on ainoana suomalaisena kohteena hyväksytty Unescon Memory of the World - rekisteriin.
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Invocatio: D.O.M.D.
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Arkit: 1 arkintunnukseton lehti, C-D8.
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Dedicatio: Johannes Agricola.