Experimental studies of the advanced fast ignitor scheme

Guided compression offers an attractive route to explore some of the physics issues of hot electron heating and transport in the fast ignition route to inertial confinement fusion, whilst avoiding the difficulties associated with establishing the stability of the channel formation pulse. X-ray images are presented that show that the guided foil remains hydrodynamically stable during the acceleration phase, which is confirmed by two-dimensional simulations. An integrated conical compression/fast electron heating experiment is presented that confirms that this approach deserves detailed study. (C) 2000 American Institute of Physics. [S1070-664X(00)02809-3].

Experimental studies of near-surface temperature cycling and surface wetting of stone and its implications for salt weathering

It has long been accepted that thermal and moisture regimes within stonework exert a major influence upon patterns of salt movement and, subsequently, the type and severity of salt-induced decay. For example, it is suggested that slow drying is more likely to bring dissolved salts to the surface, whereas rapid drying could result in the retention of some salt at or near the frequent wetting depth. In reality however, patterns of heating, cooling and surface wetting regimes that drive them – are complex and inconsistent responses to a wide range of environmental controls. As a first step to understanding the complexity of these relationships, this paper reports a series of experiments within a climatic cabinet designed to replicate the effects of short-term temperature fluctuations on the surface and sub-surface temperature regimes of a porous Jurassic limestone, and how they are influenced by surface wetting, ambient temperature and surface airflow. Preliminary results confirm the significance of very steep temperature/stress gradients within the outer centimetre or less of exposed stone under short-duration cycles of heating and cooling. This is important because this is the zone in which many stone decay processes, particularly salt weathering, operate, these processes invariably respond to temperature and moisture fluctuations, and short-term interruptions to insolation could, for example,
trigger these fluctuations on numerous occasions over a day. The data also indicate that there are complex patterns of temperature reversal with depth that are influenced in their intensity and location by surface wetting and moisture penetration, airflow across the surface and ambient air temperature. The presence of multiple temperature reversals and their variation over the course of heating and cooling phases belies previous assumtions of smooth, exponential increases and decreases in subsurface temperatures in response, for example to diurnal patterns of heating and cooling

The impedance cardiogram recorded through two electrocardiogram/defibrillator pads as a determinant of cardiac arrest during experimental studies

OBJECTIVE: Laypersons are poor at emergency pulse checks (sensitivity 84%, specificity 36%). Guidelines indicate that pulse checks should not be performed. The impedance cardiogram (dZ/dt) is used to assess stroke volume. Can a novel defibrillator-based impedance cardiogram system be used to distinguish between circulatory arrest and other collapse states?

DESIGN: Animal study.

SETTING: University research laboratory.

SUBJECTS: Twenty anesthetized, mechanically ventilated pigs, weight 50-55 kg.

INTERVENTIONS: Stroke volume was altered by right ventricular pacing (160, 210, 260, and 305 beats/min). Cardiac arrest states were then induced: ventricular fibrillation (by rapid ventricular pacing) and, after successful defibrillation, pulseless electrical activity and asystole (by high-dose intravenous pentobarbitone).

MEASUREMENTS AND MAIN RESULTS: The impedance cardiogram was recorded through electrocardiogram/defibrillator pads in standard cardiac arrest positions. Simultaneously recorded electro- and impedance cardiogram (dZ/dt) along with arterial blood pressure tracings were digitized during each pacing and cardiac arrest protocol. Five-second epochs were analyzed for sinus rhythm (20 before ventricular fibrillation, 20 after successful defibrillation), ventricular fibrillation (40), pulseless electrical activity (20), and asystole (20), in two sets of ten pigs (ten training, ten validation). Standard impedance cardiogram variables were noncontributory in cardiac arrest, so the fast Fourier transform of dZ/dt was assessed. During ventricular pacing, the peak amplitude of fast Fourier transform of dZ/dt (between 1.5 and 4.5 Hz) correlated with stroke volume (r2 = .3, p < .001). In cardiac arrest, a peak amplitude of fast Fourier transform of dZ/dt of < or = 4 dB x ohm x rms indicated no output with high sensitivity (94% training set, 86% validation set) and specificity (98% training set, 90% validation set).

CONCLUSIONS: As a powerful clinical marker of circulatory collapse, the fast Fourier transformation of dZ/dt (impedance cardiogram) has the potential to improve emergency care by laypersons using automated defibrillators.

Thick-microstructures for MPGDs: simulations and experimental studies

Cherenkov Imaging counters require large photosensitive areas, capable of single photon detection, operating at stable high gains under radioactive backgrounds while standing high rates, providing a fast response and a good time resolution, and being insensitive to magnetic fields. The development of photon detectors based in Micro Pattern Gaseous detectors (MPGDs), represent a new generation of gaseous photon detectors. In particular, gaseous detectors based on stacked Thick-Gaseous Electron Multipliers (THGEMs), or THGEM based structures, coupled to a CsI photoconverter coating, seem to fulfil the requirements imposed by Cherenkov imaging counters. This work focus on the study of the THGEM-based detectors response as function of its geometrical parameters and applied voltages and electric fields, aiming a future upgrade of the Cherenkov Imaging counter RICH-1 of the COMPASS experiment at CERN SPS. Further studies to decrease the fraction of ions that reach the photocathode (Ion Back Flow – IBF) to minimize the ageing and maximize the photoelectron extraction are performed. Experimental studies are complemented with simulation results, also perfomed in this work.

Disorder prediction methods, their applicability to different protein targets and their usefulness for guiding experimental studies

The role and function of a given protein is dependent on its structure. In recent years, however, numerous studies have highlighted the importance of unstructured, or disordered regions in governing a protein’s function. Disordered proteins have been found to play important roles in pivotal cellular functions, such as DNA binding and signalling cascades. Studying proteins with extended disordered regions is often problematic as they can be challenging to express, purify and crystallise. This means that interpretable experimental data on protein disorder is hard to generate. As a result, predictive computational tools have been developed with the aim of predicting the level and location of disorder within a protein. Currently, over 60 prediction servers exist, utilizing different methods for classifying disorder and different training sets. Here we review several good performing, publicly available prediction methods, comparing their application and discussing how disorder prediction servers can be used to aid the experimental solution of protein structure. The use of disorder prediction methods allows us to adopt a more targeted approach to experimental studies by accurately identifying the boundaries of ordered protein domains so that they may be investigated separately, thereby increasing the likelihood of their successful experimental solution.

Research contributions to development of particulate reinforced MMCs by theoretical and experimental studies

This thesis is a compilation of eighty publications on analytical, experimental and numerical studies on the mechanical, tribological and corrosion behaviour of metal matrix composites (MMCs). The models based on the interface between matrix and reinforcement behaviour help accurate prediction of density and locked up hysterysis-strain in the composites at elevated temperatures.

Damage identification of slab–girder structures: experimental studies

Slab–girder structures composed of steel girder and reinforced concrete slab are widely used in buildings and bridges in the world. Their advantages are largely based on the composite action through the shear connection between slab and girder. In order to assess the integrity of this kind of structures, numerous vibration-based damage identification methods have been proposed. In this study, a scaled composite slab–girder model was constructed in the laboratory. Some removable shear connectors were specially designed and fabricated to connect the girder and slab that were cast separately. Then, a two-stage experiment including both static and vibration tests was performed. In the first stage, vibration tests were conducted under different damage scenarios, where a certain number of shear connectors at certain locations were removed step by step. In the second stage, two sets of hydraulic loading equipment were used to apply four-point static loads in the test. The loads are increased gradually until concrete slab cracked. The loading histories as well as deflections at different points of the beam are recorded. Vibration test was carried out before and after concrete cracking. Experimental results show that the changes of mode shapes and relative displacement between slab and girder may be two promising parameters for damage identification of slab–girder structures.

Experimental studies and modelling of the deformation behaviour of multiple nanolayers

Microcompression tests were performed on monolithic Cu and Fe thin films and a Cu/Fe multilayer that had each individual layer of 200 nm thick, to understand the mechanical behaviour of multiple nanolayers. The micron-sized pillars were prepared by focused-ion beam (FIB) technique and compressed with a flat punch in a nanoindenter. The flow curves of the monolithic Cu and Fe thin films and Cu/Fe multilayer were extracted from the microcompression tests. The monolithic Cu thin film bulges in the top region of the pillar, while the Fe thin film cracks due to its columnar grain structure. For the Cu/Fe multilayer, the ductile Cu layers accommodate the majority of plastic deformation upon compression, while cracking in the Fe layers leads to the failure of the multilayer. Finite element models of microcompression tests were also developed to provide insights into the deformation behaviours of the multilayer and monolithic thin films. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.