The stability of alcohol consumption between age 16 and 26: Evidence from a National Birth Cohort Study

This study examined the association between moderate drinking at age 16 (adolescence) and alcohol consumption at age 26 (young adulthood), whilst controlling for possible confounding effects at the individual and family level (assessed at birth and age 10). Using the British Cohort Study (BCS70), 6515 respondents provided data on their adolescent alcohol consumption and other behaviours. Of these, 4392 also completed the survey at age 26. Consumption patterns established in adolescence persisted, to a large degree, into early adulthood. Those adolescents who drank moderately in adolescence drank significantly less in adulthood than those adolescents who drank to heavy or hazardous levels. Implications for health promotion strategies and guidance are discussed.

Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy

BACKGROUND: Ras signaling regulates a number of important processes in the heart, including cell growth and hypertrophy. Although it is known that defective Ras signaling is associated with Noonan, Costello, and other syndromes that are characterized by tumor formation and cardiac hypertrophy, little is known about factors that may control it. Here we investigate the role of Ras effector Ras-association domain family 1 isoform A (RASSF1A) in regulating myocardial hypertrophy.

METHODS AND RESULTS: A significant downregulation of RASSF1A expression was observed in hypertrophic mouse hearts, as well as in failing human hearts. To further investigate the role of RASSF1A in cardiac (patho)physiology, we used RASSF1A knock-out (RASSF1A(-)(/)(-)) mice and neonatal rat cardiomyocytes with adenoviral overexpression of RASSF1A. Ablation of RASSF1A in mice significantly enhanced the hypertrophic response to transverse aortic constriction (64.2% increase in heart weight/body weight ratio in RASSF1A(-)(/)(-) mice compared with 32.4% in wild type). Consistent with the in vivo data, overexpression of RASSF1A in cardiomyocytes markedly reduced the cellular hypertrophic response to phenylephrine stimulation. Analysis of molecular signaling events in isolated cardiomyocytes indicated that RASSF1A inhibited extracellular regulated kinase 1/2 activation, likely by blocking the binding of Raf1 to active Ras.

CONCLUSIONS: Our data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway.

Assessing elements of a family approach to reduce adolescent drinking frequency: parent-adolescent relationship, knowledge management, and keeping secrets

AIMS: To estimate 1) the associations between parent-adolescent relationship, parental knowledge and subsequent adolescent drinking frequency and 2) the influence of alcohol use on parental knowledge.

DESIGN: Path analysis of school based cohort study with annual surveys SETTING: Post primary schools from urban and intermediate/rural areas in Northern Ireland PARTICIPANTS: 4,937 post primary school students aged around 11 years in 2000 followed until around age 16 in 2005.

MEASUREMENTS: Pupil reported measures of: frequency of alcohol use; parental-child relationship quality; sub-dimensions of parental monitoring: parental control, parental solicitation, child disclosure and child secrecy.

FINDINGS: Higher levels of parental control (Ordinal logistic OR 0.86 95% CI 0.78, 0.95) and lower levels of child secrecy (OR 0.83 95% CI 0.75 0.92) were associated with less frequent alcohol use subsequently. Parental solicitation and parent-child relationship quality were not associated with drinking frequency. Weekly alcohol drinking was associated with higher subsequent secrecy (Beta -0.42 95% CI -0.53, -0.32) and lower parental control (Beta -0.15 95% CI -0.26, -0.04). Secrecy was more strongly predictive of alcohol use at younger compared with older ages (P=0.02), and alcohol use was less strongly associated with parental control among families with poorer relationships (P=0.04).

CONCLUSIONS: Adolescent alcohol use appears to increase as parental control decreases and child secrecy increases. Greater parental control is associated with less frequent adolescent drinking subsequently, while parent-child attachment and parental solicitation have little influence on alcohol use. 

Bell Family Bible, Deaths, 1862-1916

A single page from the Deaths section of the Bell Family Bible listing the names and dates of death for various members of the family.The handwritten entries appear to read as follows: "John William Taylor, died April 30th Anne Domini 1862; aged 52 years. Jess J Bell died April 11th 1872 O Mary Franices Bell died August 20th 1872. Mrs. Susan Hall. Died May, 24th, 1898 Born January 1st 1829 age. 69 William B Bell died March 19th 1897 Richard Jones died June 6th 1912 Mastam Jone died Charles H. Hall died November 11th 1916."

Bell Family Bible, Family Record, 1853-1897

The Family Record page from the Bell Family Bible providing information on the births of Bell ancestors. Relatives of the Bell family include former American slaves who later settled in Canada. This Bible was in the possession of the Rick Bell Family of St. Catharines, Ontario.

Bell Family Bible, Marriages, Tyrell - Gains, 1849

The Marriages page from the Bell Family Bible listing the marriage of Lewis Tyrell to Jane Gains on Aug. 31, 1849 at Culpepper Court House, Virginia. This Bible was in the possession of the Richard Bell Family of St. Catharines, Ontario. Ancestors of the Bell family include former American slaves who settled in Canada.

Bell Family Bible, Deaths, Tyrrell, 1886-1908

The Deaths page from the Bell Family Bible listing the deaths of Jane Tyrrell in 1886, William C. Tyrrell in 1898, and Lewis Tyrrell in 1908. This Bible was in the possession of the Rick Bell family of St. Catharines, Ontario. Relatives of the Bell family were former Black slaves from the United States who settled in Canada.The handwritten entry appears to read as follows: "Jane Tyrrell, died March 1st 1886 age 64 yrs. William C. Tyrrell died January 15th 1898 by accident in Albany N.Y. age 33 yrs 3 months Lewis Tyrrell died September 25th 1908 at his late residence Vine and Welland Ave. St. Catharines age 81 yrs 5 months." There are various spellings of the Tyrrell name within the Bell family archive. Other forms of the name include Tyrell, Tyrrill, and Terrell.

Bell Family Bible, Miscellaneous, 1895 - 1918

A page from the Bell Family Bible entitled "Miscellaneous" recording the dates and places of birth of the children of Charles and Mary Bell. The birth dates for the eight children listed range from 1895 to 1918. There is also a single entry under the heading "Age of Children of Delbert Bell". This Bible was in the possession of the Rick Bell of St. Catharines. The Bell family is descended from former Black slaves from the United States who settled in Canada.The handwritten entries appear to be as follows: "Ages of the children of Charles and Mary Bell are Wilbert Otto Bell born November 7th 1895 Erie Pa. Edna Beatrice Bell born May 25th 1897 Erie Pa. Lewis Terrell Bell born April 8th 1899 St. Catharines Ont. Gertrude Bell born November 26th 1902 St. Catharines Ont. Charles Henry Bell born June 6th 1906 St. Catharines Ont. Richard Wilson Bell born March 19th 1911 William Willoughby Bell born May 2nd 1912 both in St. Catharines Ontario Age of Children of Delbert Bell March 12th 1918 Delbert Charlie Bell"

Photograph of Rev. and Mrs. Wright and Family signed to Mrs. Mary Bell [n.d.]

An undated black and white studio portrait of Rev. and Mrs. Wright and family presented to Mrs. Mary Bell. The photograph is mounted in a decorative board frame and bears the handwritten inscription "Mrs. Mary Bell from Mrs. and Rev. Wright" on the reverse. This photograph was included in memorabilia owned by the Richard Bell family of St. Catharines, Ontario.

Photograph of Bell Family Relative [n.d.]

Small black and white photograph mounted on black card of an unidentified Bell family relative, possibly a sibling of Irene Bell, whose photo is similarly featured. This undated photograph was in the possession of the Rick Bell family, whose relatives include former Black slaves from the United States.According to the 1911 Census of Canada, Irene Bell had the following siblings: Ernest Bell, born 1889 Archie Bell, born 1895 Allen Bell, born 1901 Kenneth Bell, born 1910

Photograph of Irene Bell age 16 years, 1909

An unidentified girl, believed to be Irene Bell, is featured in this small black and white portrait photograph. Handwritten inscription on the reverse indicates the photo was presented in August 1909. The name of the recipient is illegible. This photo was in the possession of the Rick Bell family of St. Catharines, Ontario.According to entries in the Bell Family Bible, Irene Frances Bell, daughter of George A. Bell and Nellie F. Bell, was born on Jan. 19, 1893. This would make her 16-years-old at the time this photograph was presented in 1909.