Service life of retroreflective traffic signs /

"October 1991."

Traffic operations control for older drivers /

"FHWA-RD-94-119."

Fuel consumption study. Urban traffic control system (UTCS) software support project. Final report.

Federal Energy Administration, Office of Transportation Policy and Research, Washington, D.C.

Variable message signing for traffic surveillance and control - a state of the art report. Final report.

Mode of access: Internet.

Minimum retroreflectivity requirements for traffic signs: summary report.

Mode of access: Internet.

Traffic controls for construction and maintenance work zones. Volume I - office function.

Federal Highway Administration, Washington, D.C.

Traffic controls for construction and maintenance work zones. Volume II - field function.

Federal Highway Administration, Washington, D.C.

A Comparison of methods for evaluating network traffic control systems /

Mode of access: Internet.

Manual on uniform traffic control devices for streets and highways.

Updated by continuing supplements and cumulated irregularly.

Illinois supplement to the national manual on uniform traffic control devices.

"Adopted March 1990."

Illinois supplement to the national manual on uniform traffic control devices /

"March 10, 2011."--cover letter.

Quality standard for work zone traffic control devices, 1998.

These standards, covering highway work zone traffic control devices, were developed for suppliers and contractors doing work for the Illinois Dept. of Transportation.

Traffic control systems in construction workzones /

"Final Report, November 1997-October 1999."

National practices for the operation and protection of school zones and crossings; an informational report by Committee on Traffic, Subcommittee on Traffic Control Devices in cooperation with Colorado Department of Highways.

Cover title.

Role of fibroblast growth factor receptor in regulation of membrane traffic

Several studies show that membrane transport mechanisms are regulated by signalling molecules. Recently, genome-wide screen analyses in C.elegans have enabled scientists to identify novel regulators in membrane trafficking and also signalling molecules which are found to couple with this machinery. Fibroblast growth factor (FGF) via binding to fibroblast growth factor receptor (FGFR) mediate signals which are essential in the development of an organism, patterning, cell migration and tissue homeostasis. Impaired FGFR-mediated signalling has been associated with various developmental, neoplastic, metabolic and neurological diseases and cancer. In this study, the potential role of FGFR-mediated signalling pathway as a regulator of membrane trafficking was investigated. The GFP-tagged yolk protein YP170-GFP trafficking was analysed in worms where 1) FGFR signalling cascade components were depleted by RNAi and 2) in mutant animals. From these results, it was found that the disruption of the genes egl-15 (FGFR), egl-17(FGF), let-756(FGF), sem-5, let-60, lin-45, mek-2, mpk-1 and plc-3 lead to abnormal localization of YP170-GFP, suggesting that signalling downstream of FGFR via activation of MAPK and PLC-γ pathway is regulating membrane transport. The route of trafficking was further investigated, to pinpoint which membrane step is regulated by worm FGFR, by analysing a number of GFP-tagged intracellular membrane markers in the intestine of Wild Type (WT) and FGFR mutant worms. FGFR mutant worms showed a significant difference in the localisation of several endosomal membrane markers, suggesting its regulatory role in early and recycling steps of endocytosis. Finally, the trafficking of transferrin in a mammalian NIH/3T3 cell line was investigated to identify the conservation of these membrane trafficking regulatory mechanisms between organisms. Results showed no significant changes in transferrin trafficking upon FGFR stimulation or inhibition.