Sociogenomics of Cooperation and Conflict during Colony Founding in the Fire Ant Solenopsis invicta.

One of the fundamental questions in biology is how cooperative and altruistic behaviors evolved. The majority of studies seeking to identify the genes regulating these behaviors have been performed in systems where behavioral and physiological differences are relatively fixed, such as in the honey bee. During colony founding in the monogyne (one queen per colony) social form of the fire ant Solenopsis invicta, newly-mated queens may start new colonies either individually (haplometrosis) or in groups (pleometrosis). However, only one queen (the "winner") in pleometrotic associations survives and takes the lead of the young colony while the others (the "losers") are executed. Thus, colony founding in fire ants provides an excellent system in which to examine the genes underpinning cooperative behavior and how the social environment shapes the expression of these genes. We developed a new whole genome microarray platform for S. invicta to characterize the gene expression patterns associated with colony founding behavior. First, we compared haplometrotic queens, pleometrotic winners and pleometrotic losers. Second, we manipulated pleometrotic couples in order to switch or maintain the social ranks of the two cofoundresses. Haplometrotic and pleometrotic queens differed in the expression of genes involved in stress response, aging, immunity, reproduction and lipid biosynthesis. Smaller sets of genes were differentially expressed between winners and losers. In the second experiment, switching social rank had a much greater impact on gene expression patterns than the initial/final rank. Expression differences for several candidate genes involved in key biological processes were confirmed using qRT-PCR. Our findings indicate that, in S. invicta, social environment plays a major role in the determination of the patterns of gene expression, while the queen's physiological state is secondary. These results highlight the powerful influence of social environment on regulation of the genomic state, physiology and ultimately, social behavior of animals.

Analysis of nonlinear noisy integrate & fire neuron models: blow-up and steady states

Nonlinear Noisy Leaky Integrate and Fire (NNLIF) models for neurons networks can be written as Fokker-Planck-Kolmogorov equations on the probability density of neurons, the main parameters in the model being the connectivity of the network and the noise. We analyse several aspects of the NNLIF model: the number of steady states, a priori estimates, blow-up issues and convergence toward equilibrium in the linear case. In particular, for excitatory networks, blow-up always occurs for initial data concentrated close to the firing potential. These results show how critical is the balance between noise and excitatory/inhibitory interactions to the connectivity parameter.

Northern Ireland Fire (PDF 75KB)

Practice Note 3 Escape bed lifts

NIAIC - Medical Device Equipment Alerts (MEDA)

NIAIC - Medical Device Equipment Alerts

NIAIC - Medical Device and Equipment Alerts 2013

Medical Device and Equipment Alerts MDEA Updates - 2013

NIAIC - Medical Device and Equipment Alerts 2012

Medical Device and Equipment Alerts MDEA Updates - 2012

NIAIC - Medical Device and Equipment Alerts 2010

Medical Device and Equipment Alerts MDEA Updates - 2010

NIAIC - Medical Device and Equipment Alerts 2011

Medical Device and Equipment Alerts MDEA Updates - 2011

NIAIC - Medical Device and Equipment Alerts 2009

Medical Device and Equipment Alerts MDEA Updates - 2009

Disability Equipment Services in Northern Ireland Regional Summary (PDF 1815 KB)

March 2003 - main findings of the study, key recommendations and the way forward

The Fire Authority for Northern Ireland Inspection Report (PDF 67 KB)

Northern Ireland Fire Brigade - 10th and 11th March 2005

Northern Ireland's Fire and Rescue Service - Consultation Paper

Northern Ireland's Fire and Rescue Service - Consultation

Quinquennial Review of the Fire Authority of Northern Ireland Stage II Report

Quinquennial Review of the Fire Authority of Northern Ireland Stage II Report