Overexpression of Fc receptor-like 1 associated with B-cell activation during hepatitis B virus infection

The role of B cells in the pathogenesis of hepatitis B virus (HBV) infection has not been explored in depth. In the present study, the activation status of B cells from peripheral blood of healthy controls (N = 20) and patients with acute hepatitis B (AHB, N = 15) or chronic hepatitis B (CHB, N = 30) was evaluated by measuring the expression levels of B-cell activation markers CD69 and CD86, using quantitative real-time PCR and flow cytometry. Moreover, the potential mechanism underlying B-cell activation during HBV infection was further investigated by analyzing the expression profile of FCRL1, an intrinsic activation molecule of B cells. An elevation in the levels of B-cell activation markers including CD69 and CD86 was observed in the AHB patients (44.31 ± 9.27, 27.64 ± 9.26%) compared to CHB patients (30.35 ± 11.27, 18.41 ± 6.56%, P < 0.05), which was still higher than healthy controls (12.23 ± 7.84, 8.22 ± 3.43%, P < 0.05). Furthermore, the expression of FCRL1 was found to be similar to B-cell activation markers, which was highest in AHB patients (70.15 ± 17.11%), lowest in healthy donors (36.32 ± 9.98%, P < 0.05) and half-way between these levels in patients with CHB (55.17 ± 12.03%, P < 0.05). The results were positively associated with aberrant B-cell activation. These data suggest that B cells can play a role in HBV infection, and therefore more effort should be devoted to exploring their functions.

De integritate vocis Kaári Psalm. XXII.17

Variantti B.

De integritate vocis Kaári Psalm. XXII.17

Variantti A.

Development and optimization of a HPLC-RI method for the determination of major sugars in apple juice and evaluation of the effect of the ripening stage

The sugars in apple juice prove its authenticity and its sensory and nutritional properties. The aim of this study was to develop and validate a simple analytical method using high performance liquid chromatography with refractive index detection (HPLC-RI) to determinate and quantify the sugars sucrose, D-glucose, D-fructose, and D-sorbitol polyol in apple juices, as well as to analyze the juices from the Fuji suprema and Lis Gala cultivars at three ripening stages. The analytical performance parameters evaluated indicated that the method was specific for the compounds analyzed, and the linearity of the calibration curves of sugars showed high correlation coefficients (close to 1.0). The limits of detection and quantification are consistent with recommendations available in the literature for this type of matrix. Sample preparation is simple and generates small amount of residues. Over 70% of the sugars were determined in the juices of apples at the pre-ripe stage, with an increase during senescence. This method is applicable for the determination of sugars in juices and evaluation of apple ripening.

新註便蒙演說日記故事Xin zhu bian meng yan shuo ri ji gu shi.Recueil d'exemples moraux pour les enfants ; autre titre : 新增註釋演說二十四孝故事Xin zeng zhu shi yan shuo er shi si xiao gu shi.Les vingt-quatre exemples de piété filiale expliqués et développés.

Comprenant les vingt-quatre traits de piété filiale avec gravures (livre 1), des exemples d'intelligence précoce (livre 2), de bonne éducation domestique (livre 3), de perfectionnement de soi-même (livre 4), de fidélité et de dévouement (livre 5).

新鍥重訂補遺音釋大字日記故事大成Xin khie chong ding bu yi yin shi da zi ri ji gu shi da cheng.Recueil de traits historiques.

Livres 2 à 8.

雍正十三年三月十五日乙酉望月食圖Yong zheng shi san nian san yue shi san ri yi you wang yue shi tu.Khūwaliyasun tob i ǰuwan ilaci aniya ilan biya tofokhon de niokhon čoko inenkgi biya ǰetere nirugan.

Figures de l'éclipse de lune du 7 avril 1735. Textes mantchou et Chinois ; figures de l'éclipse pour diverses provinces.

崇禎曆書 。日躔曆指Chong zheng li shu. — Ri chan li zhi.Collection relative au calendrier, années Chong zheng : théorie du mouvement du soleil.

Comparer aussi Cat. imp., liv. 106, f. 21 (Xin fa suan shu, 100 livres).Par les PP. Giacomo Rho (1590-1638), Nicolao Longobardi et Adam Schall ; publié sous la direction de Xu Guang qi. Édition antérieure à 1644. Texte et figures.

崇禎曆書 。日躔表Chong zheng li shu. — Ri chan biao.Collection relative au calendrier, années Chong zheng : tables du mouvement du soleil.

Voir aussi Cat. imp., liv. 106, f. 21 (Xin fa suan shu, 100 livres).Par les PP. Rho et Schall ; publié sous la direction de Xu Guang qi. Édition antérieure à 1644.