Keyserliche Execution vber die Aechter vnd Malefitz Personen in Franckfuhrt am Mayn ergangenn : 1616

Simon Severin Aegemann fecit Anno 1616[?]

Efficient pyrophosphorolysis by a hepatitis B virus polymerase may be a primer-unblocking mechanism

Effective antiviral agents are thought to inhibit hepatitis B virus (HBV) DNA synthesis irreversibly by chain termination because reverse transcriptases (RT) lack an exonucleolytic activity that can remove incorporated nucleotides. However, since the parameters governing this inhibition are poorly defined, fully delineating the catalytic mechanism of the HBV-RT promises to facilitate the development of antiviral drugs for treating chronic HBV infection. To this end, pyrophosphorolysis and pyrophosphate exchange, two nonhydrolytic RT activities that result in the removal of newly incorporated nucleotides, were characterized by using endogenous avian HBV replication complexes assembled in vivo. Although these activities are presumed to be physiologically irrelevant for every polymerase examined, the efficiency with which they are catalyzed by the avian HBV-RT strongly suggests that it is the first known polymerase to catalyze these reactions under replicative conditions. The ability to remove newly incorporated nucleotides during replication has important biological and clinical implications: these activities may serve a primer-unblocking function in vivo. Analysis of pyrophosphorolysis on chain-terminated DNA revealed that the potent anti-HBV drug β-l-(−)-2′,3′-dideoxy-3′-thiacytidine (3TC) was difficult to remove by pyrophosphorolysis, in contrast to ineffective chain terminators such as ddC. This disparity may account for the strong antiviral efficacy of 3TC versus that of ddC. The HBV-RT pyrophosphorolytic activity may therefore be a novel determinant of antiviral drug efficacy, and could serve as a target for future antiviral drug therapy. The strong inhibitory effect of cytoplasmic pyrophosphate concentrations on viral DNA synthesis may also partly account for the apparent slow rate of HBV genome replication.

Modeling of Self-similar Traffic

Modeling of self-similar traffic is performed for the queuing system of G/M/1/K type using Weibull distribution. To study the self-similar traffic the simulation model is developed by using SIMULINK software package in MATLAB environment. Approximation of self-similar traffic on the basis of spline functions. Modeling self-similar traffic is carried outfor QS of W/M/1/K type using the Weibull distribution. Initial data are: the value of Hurst parameter H=0,65, the shape parameter of the distribution curve α≈0,7 and distribution parameter β≈0,0099. Considering that the self-similar traffic is characterized by the presence of "splashes" and long-termdependence between the moments of requests arrival in this study under given initial data it is reasonable to use linear interpolation splines.

Synchronistische tafeln der kirchengeschichte vom ursprunge des Christenthums bis auf die gegenwärtige zeit ... nach den bewährtesten hülfsmitteln ausgeführt, und mit einer kurzen uebersicht der begebenheiten versehen,

Mode of access: Internet.

Fest-Polonaise, für Orchester, op. 12.

Pl. no. C.W. 1132.

Fire sange /

Text, in part, by B.S. Ingemann.

Salomons sange, : af B. S. Ingemann's "Sulamith og Salomon" ; Op. 15 /

Salomons sang paa Vinbjerget -- Salomons sang paa Bjergstien -- Salomons sang i Gilead.

Grande polonaise : fest-polonaise pour orchestre, op. 12 /

Easy arrangement for piano; originally for orchestra.

Collections zoologiques du baron Edm. de Selys Longchamps.

Catalogue syste matique et descriptive publie par les soins de ses fils, avec le concours de MM. M. Burr, J. Desneux, F. Fo rster, Julien Fraipont, E. Gu nther-Enderlein, F. Klapalek, L. Kru ger, Rene Martin, F. Ris, Maurice de Selys-Longchamps, G. Severin, G. Ulmer et H. van der Weele.

Haandbog i verdenshistorien efter de bedste kilder /

Each vol. has special t.p.

Wien's Schandsäulen.

Mode of access: Internet.

De svuccino libri duo /

Mode of access: Internet.