Skehill, Caroline: History of the Present of Child Protection and Welfare Social Work in Ireland

This unique book has at least three significant strengths. First, it offers an interesting angle on Irish social history and how social work and child protection and welfare services have been developed from the 1860s to the 1990s. Secondly, the author uses the 'history of the present' method of Michel Foucault in a promising manner, incorporating his concepts of archaeology, genealogy and discourse. Most of all she has succeeded in further developing Michel Foucault's concepts and strategies of writing. Although this is a national history, she has made a remarkable contribution to social work research. Her conceptual and methodological innovations are undoubtedly fully applicable to other social and societal contexts. This book is recommendable to those who want to implement genealogical analysis in their own research. Thirdly, her skill in writing and the way she renders the difficult language and concepts of Michel Foucault accessible means that here is a book that can also be read with ease by those whose mother tongue is not English. From the viewpoint of women and women's research the focus in this book is minor but if you are interested in social work history and genealogical analysis, this is a book you have to read!

β1-Class Integrins Regulate the Development of Laminae and Folia in the Cerebral and Cerebellar Cortex

Mice that lack all beta1-class integrins in neurons and glia die prematurely after birth with severe brain malformations. Cortical hemispheres and cerebellar folia fuse, and cortical laminae are perturbed. These defects result from disorganization of the cortical marginal zone, where beta1-class integrins regulate glial endfeet anchorage, meningeal basement membrane remodeling, and formation of the Cajal-Retzius cell layer. Surprisingly, beta1-class integrins are not essential for neuron-glia interactions and neuronal migration during corticogenesis. The phenotype of the beta1-deficient mice resembles pathological changes observed in human cortical dysplasias, suggesting that defective integrin-mediated signal transduction contributes to the development of some of these diseases.

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.

Major Evans Gordon über die Juden

Evans Gordon

Ein ungedruckter Brief von Caroline Herder an Garlieb Merkel

Paul Michaelis

Die Frage nach dem Sinn des Judentums : dem Andenken meiner Mutter Caroline Schlesinger geb. Fränkel

Abraham Schlesinger

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 476 - Strafanzeige von Caroline Marquet wegen Körperverletzung durch Schopenhauer am 12. August 1821

u.a.: Carolin Médon; Martin Hinrich; Carl Lichtenstein;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 477 - Ermittlungsergebnisse des Königlichen Hausvogteigerichts Berlin in Sachen der Schadenersatzklage von Caroline Marquet

u.a.: Carolin Médon;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 483 - Protokollabschriften des Gerichtsprozesses zur Schadenersatzklage Caroline Marquet

u.a.: Gutachten von Dr. Horn, Dr. Kluge; Vergleichsvorschläge; Notizen Schopenhauers;