The prognostic value of cytology and fluorescence in situ hybridization in the follow-up of nonmuscle-invasive bladder cancer after intravesical Bacillus Calmette-Guérin therapy

Molecular markers reliably predicting failure or success of Bacillus Calmette-Guérin (BCG) in the treatment of nonmuscle-invasive urothelial bladder cancer (NMIBC) are lacking. The aim of our study was to evaluate the value of cytology and chromosomal aberrations detected by fluorescence in situ hybridization (FISH) in predicting failure to BCG therapy. Sixty-eight patients with NMIBC were prospectively recruited. Bladder washings collected before and after BCG instillation were analyzed by conventional cytology and by multitarget FISH assay (UroVysion, Abbott/Vysis, Des Plaines, IL) for aberrations of chromosomes 3, 7, 17 and 9p21. Persistent and recurrent bladder cancers were defined as positive events during follow-up. Twenty-six of 68 (38%) NMIBC failed to BCG. Both positive post-BCG cytology and positive post-BCG FISH were significantly associated with failure of BCG (hazard ratio (HR)= 5.1 and HR= 5.6, respectively; p < 0.001 each) when compared to those with negative results. In the subgroup of nondefinitive cytology (all except those with unequivocally positive cytology), FISH was superior to cytology as a marker of relapse (HR= 6.2 and 1.4, respectively). Cytology and FISH in post-BCG bladder washings are highly interrelated and a positive result predicts failure to BCG therapy in patients with NMIBC equally well. FISH is most useful in the diagnostically less certain cytology categories but does not provide additional information in clearly malignant cytology.

Pliocene Paleoenvironment and Antarctic Ice Sheet Behavior: Evidence from Wright Valley

Investigations in Wright Valley, adjacent to the Transantarctic Mountains in East Antarctica, shed light on the question of whether high-latitude Pliocene climate was warm enough to cause widespread deglaciation of the East Antarctic craton with a concurrent Magellanic moorland-like environment. If Pliocene age diatoms, presently in glaciogenic deposits high in the Transantarctic Mountains, had come from seaways on the East Antarctic craton, an expanding Late Pliocene ice sheet must have first eroded them from marine sediments and then deposited the diatoms at their present high-altitude locations. This hypothetical expanding glacier would have had to have come through Wright Valley. Glacial drift sediments from the central Wright Valley were mapped, sampled, analyzed, and Ar-40/Ar-39 whole rock dated. Our evidence indicates that an East Antarctic outlet glacier has not expanded through Wright Valley, and hence cannot have overridden the Dry Valleys sector of the Transantarctic Mountains, any time in the past 3.8 myr. Rather, there was only moderate Pliocene expansion of local cola-based alpine glaciers and continuous cold-desert conditions in Wright Valley. Persistence of a cold-desert paleoenvironment implies that the sector of the East Antarctic Ice Sheet adjacent to Wright Valley has remained relatively stable without melting ablation zones since at least 3.8 Ma, in Early Pliocene time. A further implication is that Antarctic Ice Sheet behavior in the Pliocene was much like that in the Quaternary, when the ice sheet consisted of a stable, terrestrial core in East Antarctica and a dynamic, marine-based appendage in West Antarctica.

Combat de Castalla 21 Juillet 1812 [Material gráfico] : Galrie. Histque. de Versailles

Inscripción en la parte superior: "226. 928"

The entomologist's useful compendium; or, An introduction to the knowledge of British insects, comprising the best means of obtaining and preserving them, and a description of the apparatus generally used; together with the genera of Linné, and the modern method of arranging the classes...according to the views of Dr. Leach...with instructions for collecting and fitting up objects for the microscope.

1821

Address before the second plenary session of the Ninth International Conference of American States, Bogotá, Colombia, April 1, 1948.

Mode of access: Internet.

La boulangère : opera comique in three acts and four tableaux /

Includes synopsis.

The grand duchess of Gerolstein : a comic opera in three acts /

French & English in parallel columns.

Madame Favart, comic opera : English version by H. B. Farnie /

Mode of access: Internet.

Oeuvres complètes de Beaumarchais.: Nouv. éd., augmentée de quatre pièces de théatre et documents divers inédits, avec une introduction par Édouard Fournier; ornée de vingt portraits en pied coloriés, dessinés par Émile Bayard.

Mode of access: Internet.

Capital and labor. An address delivered before the American institute of the city of New York. in celebration of its semi-centennial anniversary, on Thursday evening, October 11, 1877.

Mode of access: Internet.

Un mari à la porte; opérette en un acte.

Pl. no. H.2447.

Mr. Choufleuri restera chez lui le-- : operette bouffe en un acte /

At head of title: Bouffes Parisiens.

La belle Hélène; opéra bouffe en 3 actes. Paroles de M.M. Henri Meilhac et Ludovic Halévy. Musique de J. Offenbach. Partition chant et piano arrangée par Léon Roques.

Mode of access: Internet.

Modern trio album. [music] : fifteen special concert arrangements and original compositions for violin, cello and piano /

Elegie and consolation, op. 200, no. 2 / Atherton, Frank P. -- Hungarian dance no. 5 (in G minor) / Brahms, Johannes -- Humoreske : op. 101, no. 7 / Dvor̂ák, Anton ; arr. by Gustav Saenger -- La Cinquantaine / Gabriel-Marie ; special concert arr. by C. Arnold -- Gavotte Louis XIII : Amaryllis / Ghys, H. ; arr. by N. Hansen -- Serenade, from Op. 3 / Herbert, Victor -- Dreams of love = Liebesträume : notturno III / Liszt, Franz ; arr. by R. Klugescheid -- O Belle Nuite, Barcarolle from "Contes d'Hoffmann" / Offenbach, J. ; arr. by Max Woltag -- Celebrated Andante / Reissiger, C. G. -- My heart at thy sweet voice : Cantabile from "Samson and Dalila" / Saint-Saëns, C. ; arr. by R. Klugescheid -- Melodie Mignonne / Sinding, Christian ; arr. by N. Hansen -- Vienna life = Wiener Blut / Strauss, Johann ; special concert arr. by C. Arnold -- Autumn song = Chant d'automne ; Chant sans paroles : op. 40, no. 6 / Tschaikowsky, P. ; arr. by N. Hansen -- Song to the evening star : from "Tannhäuser" / Wagner, Richard ; concert paraphrase by C. Arnold.

Le mariage aux lanternes; operette en un acte. Paroles de Michel Carré et Leon Battu. Partition piano et chant. [Réduits au piano au H. Salomon]

French words.