496 resultados para Dorothea Orem
Resumo:
Born September 8, 1905, worked in a Jewish orphanage in Berlin and was deported to Auschwitz May 17, 1943, where she died.
Resumo:
Born September 8, 1905, worked in a Jewish orphanage in Berlin and was deported to Auschwitz May 17, 1943, where she died.
Resumo:
Paula Goldschmidt, née Harmelin, born 1880; Martin Goldschmidt, born circa 1879; Ruth Augusta Beatrice Goldschmidt, born 1923?
Resumo:
Henry, born July 15, 1914, died August 6, 1978; Ruth, born 1923?
Resumo:
Some signed by photographer Jacobi
Resumo:
Born 1880?
Resumo:
Henry, born July 15, 1914, died August 6, 1978; Ruth, born 1923?
Resumo:
Born 1879?; Married September 2, 1903 in Leipzig to Paula Harmelin; Father of Henry H. Goldschmidt Gould and Ruth Augusta Beatrice Goldschmidt
Resumo:
One photograph is stamped and signed, one is stamped with the Nazi seal
Resumo:
Paula Goldschmidt, née Harmelin, born 1880; Martin Goldschmidt, born circa 1879; Married September 2, 1903 in Leipzig
Resumo:
Born 1879?; Married September 2, 1903 in Leipzig to Paula Harmelin; Father of Henry H. Goldschmidt Gould and Ruth Augusta Beatrice Goldschmidt
Resumo:
Born 1879?; Married September 2, 1903 in Leipzig to Paula Harmelin, father of Henry H. Goldschmidt Gould and Ruth Augusta Beatrice Goldschmidt
Resumo:
Phase variation (random ON/OFF switching) of gene expression is a common feature of host-adapted pathogenic bacteria. Phase variably expressed N-6-adenine DNA methyltransferases (Mod) alter global methylation patterns resulting in changes in gene expression. These systems constitute phase variable regulons called phasevarions. Neisseria meningitidis phasevarions regulate genes including virulence factors and vaccine candidates, and alter phenotypes including antibiotic resistance. The target site recognized by these Type III N-6-adenine DNA methyltransferases is not known. Single molecule, real-time (SMRT) methylome analysis was used to identify the recognition site for three key N. meningitidis methyltransferases: ModA11 (exemplified by M.NmeMC58I) (5'-CGY(m6)AG-3'), ModA12 (exemplified by M.Nme77I, M.Nme18I and M.Nme579II) (5'-AC(m6)ACC-3') and ModD1 (exemplified by M.Nme579I) (5'-CC(m6)AGC-3'). Restriction inhibition assays and mutagenesis confirmed the SMRT methylome analysis. The ModA11 site is complex and atypical and is dependent on the type of pyrimidine at the central position, in combination with the bases flanking the core recognition sequence 5'-CGY(m6)AG-3'. The observed efficiency of methylation in the modA11 strain (MC58) genome ranged from 4.6% at 5'-GCGC(m6)AGG-3' sites, to 100% at 5'-ACGT(m6)AGG-3' sites. Analysis of the distribution of modified sites in the respective genomes shows many cases of association with intergenic regions of genes with altered expression due to phasevarion switching.