Adaptive lighting design as a holistic approach to public lighting

Dissertação para obtenção do grau de Doutor em Design, apresentada na Universidade de Lisboa - Faculdade de Arquitetura.

Diseño positivo: Innovación centrada en el bienestar humano

El ‘Diseño Positivo’ es una filosofía de innovación desarrollada por investigadores líderes en diseño experiencial de la facultad de Diseño Industrial de la Universidad Tecnológica de Delft (TU Delft), en Los Países Bajos. El ‘Diseño Positivo’ plantea estrategias de innovación que buscan esencialmente promover, facilitar o fomentar el bienestar de los usuarios. Lo hace por medio de la aplicación práctica del conocimiento derivado de la investigación científica sobre la experiencia humana: psicología positiva, psicología emocional, economía conductual. Entre los descubrimientos que se han dilucidado se encuentran modelos detallados sobre el comportamiento humano, sobre la forma en que tomamos decisiones, sobre cómo las emociones se suscitan, e incluso sobre cómo está moldeado nuestro sentido del gusto partiendo de teorías evolutivas. El Diseño Positivo busca combinar estos conocimientos científicos con marcos conceptuales sobre la experiencia del usuario (User Experience – UX) en procesos de innovación En la presentación, Simón discutió las premisas básicas del Diseño Positivo, y en especial, cómo estas pueden ser aplicadas a procesos de innovación para crear productos y servicios que generen un impacto positivo en el bienestar psicológico y felicidad de las personas. Además, discutió cómo este conocimiento podría ser aplicado en procesos de innovación en las bibliotecas

La mejora del proceso de enseñanza-aprendizaje en educación ambiental: un estudio centrado en la educación general básica de Ecuador

La crisis ambiental que atravesamos actualmente es consecuencia del avance vertiginoso de las diferentes actividades humanas, lo cual se constituye en una amenaza constante a la biodiversidad. Los problemas ambientales afectan a la totalidad de los elementos de la naturaleza, es decir: el aire, el agua, el suelo, los bosques y la cobertura vegetal en general, los animales, la energía, el clima y las personas; y ello está amenazando a la vida de las presentes y futuras generaciones. Ecuador, a pesar de su riqueza ecológica y cultural, durante las últimas décadas ha ejercido cada vez mayor presión sobre el ambiente a raíz de: el incremento acelerado de la población, la migración del campo a la ciudad, los modelos de consumo insostenibles, la explotación del llamado oro negro o petróleo, la degradación y pérdida directa de bosques, humedales y otros ecosistemas. Aspectos que constituyen un riesgo, no solo para el ambiente, sino también para la sociedad y el bienestar humano, pues la biodiversidad representa la base para la vida en nuestro planeta y es uno de los pilares fundamentales del desarrollo sostenible. Aún cuando los grandes problemas ambientales que estamos atravesando son comunes a los del resto del mundo, en Ecuador encontramos cuatro grandes problemas o macroproblemas ambientales: la destrucción y fragmentación de los hábitats, la introducción de especies exóticas, la sobreexplotación de recursos naturales y la contaminación. A éstos podríamos sumar uno más: el cambio climático global, cuyos efectos a mediano y largo plazo ponen en riesgo la biodiversidad y la calidad de vida de toda la humanidad. Ante la magnitud de los problemas ambientales que nos afectan, el universo tiene los ojos puestos en la búsqueda de alternativas a los mismos. Por esta razón, se vienen desarrollando una serie de eventos, reuniones, conferencias a nivel nacional e internacional, con el propósito de aunar esfuerzos en el diseño de políticas y estrategias generales y particulares, que permitan aproximarse al equilibrio en las relaciones del ser humano con la naturaleza...

Los mecanismos de influencia en el liderazgo

Este trabajo tiene como objetivo fundamental identificar las tácticas de influencia que utiliza el señor Carlos Pérez, gerente y socio principal de G. & M., en su trato cotidiano con sus colaboradores, así como la reacción de estos últimos ante dichas tácticas.

Competencias en educación: Ideas para el diseño curricular desde la deliberación práctica y crítica, basada en el desarrollo humano y la transformación social

Los sistemas educativos, en América Latina y en el mundo entero, están siendo llamados a dar respuesta a las exigencias de profesionales altamente formados, que respondan a los conocimientos y habilidades emergentes exigidas por los avances científicos y tecnológicos. Ante esas peticiones de la realidad económica y productiva, las competencias se han convertido en el estandarte para que los sistemas educativos planteen sus propuestas curriculares. En estas se manifiesta la ampliación de los contenidos al aprender funciones o tareas con base en adaptaciones de otros contextos, desde la experticia y sin estudios profundos de la realidad de las fuentes curriculares. En este artículo se plantea la importancia de considerar que un proyecto educativo basado en competencias profesionales se debe visualizar como un proceso de formación de la persona, de manera integral. En el análisis de esa proposición se discute el abordaje de las competencias desde la educación, el cual ha pretendido relacionar la teoría y la práctica, acercando los contenidos académicos al hacer en un puesto de trabajo, en divergencia con la necesidad de razonar las competencias en educación como el medio para integrar el conocimiento y la experiencia. No se trata solo de resolver tareas específicas en un futuro puesto de trabajo, sino también de la búsqueda de soluciones de los problemas en los diferentes ámbitos de la vida. Para el logro de esa visión integradora de la educación, se proponen algunas ideas para diseñar proyectos curriculares por competencias desde la tradición práctica deliberativa y crítica, con una concepción curricular humanista y de transformación social.

Design, Synthesis And Biological Evaluation Of Hybrid Bioisoster Derivatives Of N-acylhydrazone And Furoxan Groups With Potential And Selective Anti-trypanosoma Cruzi Activity.

Hybrid bioisoster derivatives from N-acylhydrazones and furoxan groups were designed with the objective of obtaining at least a dual mechanism of action: cruzain inhibition and nitric oxide (NO) releasing activity. Fifteen designed compounds were synthesized varying the substitution in N-acylhydrazone and in furoxan group as well. They had its anti-Trypanosoma cruzi activity in amastigotes forms, NO releasing potential and inhibitory cruzain activity evaluated. The two most active compounds (6, 14) both in the parasite amastigotes and in the enzyme contain the nitro group in para position of the aromatic ring. The permeability screening in Caco-2 cell and cytotoxicity assay in human cells were performed for those most active compounds and both showed to be less cytotoxic than the reference drug, benznidazole. Compound 6 was the most promising, since besides activity it showed good permeability and selectivity index, higher than the reference drug. Thereby the compound 6 was considered as a possible candidate for additional studies.

Study Of The Homogeneity Of Drug Loaded In Polymeric Films Using Near-infrared Chemical Imaging And Split-plot Design.

Split-plot design (SPD) and near-infrared chemical imaging were used to study the homogeneity of the drug paracetamol loaded in films and prepared from mixtures of the biocompatible polymers hydroxypropyl methylcellulose, polyvinylpyrrolidone, and polyethyleneglycol. The study was split into two parts: a partial least-squares (PLS) model was developed for a pixel-to-pixel quantification of the drug loaded into films. Afterwards, a SPD was developed to study the influence of the polymeric composition of films and the two process conditions related to their preparation (percentage of the drug in the formulations and curing temperature) on the homogeneity of the drug dispersed in the polymeric matrix. Chemical images of each formulation of the SPD were obtained by pixel-to-pixel predictions of the drug using the PLS model of the first part, and macropixel analyses were performed for each image to obtain the y-responses (homogeneity parameter). The design was modeled using PLS regression, allowing only the most relevant factors to remain in the final model. The interpretation of the SPD was enhanced by utilizing the orthogonal PLS algorithm, where the y-orthogonal variations in the design were separated from the y-correlated variation.

Doehlert Design-desirability Function Multi-criteria Optimal Separation Of 17 Phenolic Compounds From Extra-virgin Olive Oil By Capillary Zone Electrophoresis.

In Brazil, the consumption of extra-virgin olive oil (EVOO) is increasing annually, but there are no experimental studies concerning the phenolic compound contents of commercial EVOO. The aim of this work was to optimise the separation of 17 phenolic compounds already detected in EVOO. A Doehlert matrix experimental design was used, evaluating the effects of pH and electrolyte concentration. Resolution, runtime and migration time relative standard deviation values were evaluated. Derringer's desirability function was used to simultaneously optimise all 37 responses. The 17 peaks were separated in 19min using a fused-silica capillary (50μm internal diameter, 72cm of effective length) with an extended light path and 101.3mmolL(-1) of boric acid electrolyte (pH 9.15, 30kV). The method was validated and applied to 15 EVOO samples found in Brazilian supermarkets.

Design And Synthesis Of N-acylated Aza-goniothalamin Derivatives And Evaluation Of Their In Vitro And In Vivo Antitumor Activity.

Herein we describe the synthesis of a focused library of compounds based on the structure of goniothalamin (1) and the evaluation of the potential antitumor activity of the compounds. N-Acylation of aza-goniothalamin (2) restored the in vitro antiproliferative activity of this family of compounds. 1-(E)-But-2-enoyl-6-styryl-5,6-dihydropyridin-2(1H)-one (18) displayed enhanced antiproliferative activity. Both goniothalamin (1) and derivative 18 led to reactive oxygen species generation in PC-3 cells, which was probably a signal for caspase-dependent apoptosis. Treatment with derivative 18 promoted Annexin V/7-aminoactinomycin D double staining, which indicated apoptosis, and also led to G2 /M cell-cycle arrest. In vivo studies in Ehrlich ascitic and solid tumor models confirmed the antitumor activity of goniothalamin (1), without signs of toxicity. However, derivative 18 exhibited an unexpectedly lower in vivo antitumor activity, despite the treatments being administered at the same site of inoculation. Contrary to its in vitro profile, aza-goniothalamin (2) inhibited Ehrlich tumor growth, both on the ascitic and solid forms. Our findings highlight the importance of in vivo studies in the search for new candidates for cancer treatment.

Use Of Experimental Design To Optimize A Triple-potential Waveform To Develop A Method For The Determination Of Streptomycin And Dihydrostreptomycin In Pharmaceutical Veterinary Dosage Forms By Hplc-pad.

An HPLC-PAD method using a gold working electrode and a triple-potential waveform was developed for the simultaneous determination of streptomycin and dihydrostreptomycin in veterinary drugs. Glucose was used as the internal standard, and the triple-potential waveform was optimized using a factorial and a central composite design. The optimum potentials were as follows: amperometric detection, E1=-0.15V; cleaning potential, E2=+0.85V; and reactivation of the electrode surface, E3=-0.65V. For the separation of the aminoglycosides and the internal standard of glucose, a CarboPac™ PA1 anion exchange column was used together with a mobile phase consisting of a 0.070 mol L(-1) sodium hydroxide solution in the isocratic elution mode with a flow rate of 0.8 mL min(-1). The method was validated and applied to the determination of streptomycin and dihydrostreptomycin in veterinary formulations (injection, suspension and ointment) without any previous sample pretreatment, except for the ointments, for which a liquid-liquid extraction was required before HPLC-PAD analysis. The method showed adequate selectivity, with an accuracy of 98-107% and a precision of less than 3.9%.

PARAFAC: uma ferramenta quimiométrica para tratamento de dados multidimensionais. Aplicações na determinação direta de fármacos em plasma humano por espectrofluorimetria

Since the last decade, the combined use of chemometrics and molecular spectroscopic techniques has become a new alternative for direct drug determination, without the need of physical separation. Among the new methodologies developed, the application of PARAFAC in the decomposition of spectrofluorimetric data should be highlighted. The first objective of this article is to describe the theoretical basis of PARAFAC. For this purpose, a discussion about the order of chemometric methods used in multivariate calibration and the development of multi-dimensional methods is presented first. The other objective of this article is to divulge for the Brazilian chemical community the potential of the combination PARAFAC/spectrofluorimetry for the determination of drugs in complex biological matrices. For this purpose, two applications aiming at determining, respectively, doxorrubicine and salicylate in human plasma are presented.

Espécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: principais métodos analíticos para sua determinação

We review here the chemistry of reactive oxygen and nitrogen species, their biological sources and targets; particularly, biomolecules implicated in the redox balance of the human blood, and appraise the analytical methods available for their detection and quantification. Those biomolecules are represented by the enzymatic antioxidant defense machinery, whereas coadjutant reducing protection is provided by several low molecular weight molecules. Biomolecules can be injured by RONS yielding a large repertoire of oxidized products, some of which can be taken as biomarkers of oxidative damage. Their reliable determination is of utmost interest for their potentiality in diagnosis, prevention and treatment of maladies.

Movimento humano em uma perspectiva psicossomática: estudos de Judith Kestenberg

This paper considers Judith Kestenberg's approach to the psychic contextualization of human body movements, presenting: 1) the main movement categories identified by Kestenberg and their meanings; 2) the relations (affinities and shocks) within these movement patterns; 3) the relations between the initial preferences of a child for certain rhythms of movements and his/her movement patterns in adult life. The aim of this research was to present Kestenberg's studies, which offer a necessary knowledge to those willing to comprehend human body movement in a therapeutic context.

Desenvolvimento humano, lazer e educação fisica escolar : o papel do componente ludico da cultura

Universidade Estadual de Campinas. Faculdade de Educação Física

Metodologia para descrição da orientação do corpo humano

Universidade Estadual de Campinas. Faculdade de Educação Física