986 resultados para Dabney, Thomas Smith Gregory, 1798-1885.


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A handwritten translation of a power of attorney, on two folio-sized leaves, certified by Francis Sales and dated October 10, 1798. The power of attorney authorizes Isaac Whippo, an American citizen living in Bordeaux, France to act as the attorney general and special for his brother, Thomas Whippo, also an American citizen and captain of the ship the Ganges of New York. The power of attorney was created in the Office of Gabriel Duprat in Bordeaux, with William Henry Vernon translating for Thomas Whippo and was notarized by Joseph Fenwick, Consol of the United States of America on April 14, 1798.

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James Anderson's powerful critique of Adam Smith's position on the corn export bounty was published in 1777. It focuse d on Smith's proposition that the bounty could not lead to increased corn production because it could not increase corn's real price. Smit h's response to the critique is traced in later editions of Wealth of Nations. While Anderson's critique of Smith influenced Thomas Malthu s's writings from 1803 onwards, his theory of differential rent did n ot influence Malthus at this stage. An examination of the evolution o f Malthus's ideas on rent between 1803 and 1815, however, indicates t hat Malthus knew and used Anderson's work on rent.

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Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P <5 × 10(-8). These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P <5 × 10(-8) for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL. A genetic risk score combining SNP genotypes from all loci showed similar ability to distinguish cases and controls in all samples examined. Our findings provide new directions for biological, genetic and therapeutic studies of AMD.