966 resultados para Competent authority


Relevância:

20.00% 20.00%

Publicador:

Resumo:

Audit report on the Great River Regional Waste Authority for the years ended June 30, 2005 and 2006.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Agency Performance Plan

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Audit report on the Iowa State Fair Authority for the year ended October 31, 2006

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Audit report on the Iowa Water Pollution Control Works Financing Program (Clean Water Program) and the Iowa Drinking Water Facilities Financing Program (Drinking Water Program), joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources, for the year ended June 30, 2006

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Background: To enhance the induction of insert specific immune responses, a new generation of replication competent poxvirus vectors was designed and evaluated against non-replicating poxvirus vectors in a HIV vaccine study in non human primates.Methods: Rhesus macaques were immunized with either the non-replicating variant NYVAC-GagPolNef HIV-1 clade C or the replicating NYVAC-GagPolNef-C-KC, boosted with HIVGag- PolEnv-SLP and immune responses were monitored.Results: Gag-specific T-cell responses were only detected in animals immunized with the replicating NYVAC-GagPolNef-C-KC variant. Further enhancement and broadening of the immune response was studied by boosting the animals with novel T-cell immunogens HIVconsv synthetic long peptides (SLP), which direct vaccine-induced responses to the most conserved regions of HIV and contain both CD4 T-helper and CD8 CTL epitopes. The adjuvanted (Montanide ISA-720) SLP divided into subpools and delivered into anatomically separate sites enhanced the Gag-specific T-cell responses in 4 out of 6 animals, to more than 1000 SFC/106 PBMC in some animals. Furthermore, the SLP immunization broadened the immune response in 4 out of 6 animals to multiple Pol epitopes. Even Env-specific responses, to which the animals had not been primed, were induced by SLP in 2 out of 6 animals.Conclusion: This new immunization strategy of priming with replicating competent poxvirus NYVAC-HIVGagPolNef and boosting with HIVGagPolEnv-SLP, induced strong and broad Tcell responses and provides a promising new HIV vaccine approach. This study was performed within the Poxvirus T-cell Vaccine Discovery Consortium (PTVDC) which is part of the CAVD program.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The Iowa Railway Finance Authority (IRFA) was created in 1980 by the 68th General Assembly to provide for the financing of rail facilities, and to enhance and continue the operation of essential rail facilities. IRFA was authorized to offer financial assistance for the acquisition, rehabilitation, construction, refinancing, extension, replacement, maintenance, repair or leasing of any rail facility. The 2005 legislative session amended Iowa Code 327H.20 by assigning all repayments of IRFA and other Iowa DOT rail assistance loans to the Rail Revolving Loan and Grant Fund. In 2006, a state appropriation of $235,000 was added to the program. In 2007, $2 million was appropriated to support rail development and job growth.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Audit report on the Iowa Lottery Authority for the year ended June 30, 2007

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Audit report on the Iowa Water Pollution Control Works Financing Program and the Iowa Drinking Water Facilities Financing Program, joint programs of the Iowa Finance Authority and the Iowa Department of Natural Resources for the year ended June 30, 2007

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Audit report on the Great River Regional Waste Authority for the year ended June 30, 2007

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Agency Performance Plan, Iowa Finance Authority

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Agency Performance Plan, Iowa Lottery Authority

Relevância:

20.00% 20.00%

Publicador:

Resumo:

This report outlines the strategic plan for Iowa Finance Authority, goals and mission.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Audit report on the Iowa Agricultural Development Authority for the year ended June 30, 2008