Early occurrence of lung adenocarcinoma and breast cancer after radiotherapy of a chest wall sarcoma in a patient with a de novo germline mutation in TP53

We report a 26-year-old female patient who was diagnosed within 4 years with chest sarcoma, lung adenocarcinoma, and breast cancer. While her family history was unremarkable, DNA sequencing of TP53 revealed a germline de novo non-sense mutation in exon 6 p.Arg213X. One year later, she further developed a contralateral ductal carcinoma in situ, and 18 months later a jaw osteosarcoma. This case illustrates the therapeutic pitfalls in the care of a young cancer patient with TP53 de novo germline mutations and the complications related to her first-line therapy. Suggestion is made to use the less stringent Chompret criteria for germline TP53 mutation screening. Our observation underlines the possibly negative effect of radiotherapy in generating second tumors in patients with a TP53 mutation. We also present a review of six previously reported cases, comparing their cancer phenotypes with those generally produced by TP53 mutations.

Early-onset Crohn's disease is a risk factor for smaller final height.

OBJECTIVES Growth retardation is a frequent complication of paediatric inflammatory bowel disease (IBD). Only a few studies report the final height of these patients, with controversial results. We compared adult height of patients with paediatric IBD with that of patients with adult-onset disease. METHODS Height data of 675 women 19-44 years of age and 454 men 23-44 years of age obtained at inclusion in the Swiss IBD cohort study registry were grouped according to the age at diagnosis: (a) prepubertal (men≤13, women≤11 years), (b) pubertal (men 13-22, women 11-18 years) and (c) adult (men>22, women>18 years of age), and compared with each other and with healthy controls. RESULTS Male patients with prepubertal onset of Crohn's disease (CD) had significantly lower final height (mean 172±6 cm, range 161-182) compared with men with pubertal (179±6 cm, 161-192) or adult (178±7 cm, 162-200) age at onset and the general population (178±7 cm, 142-204). Height z-scores standardized against heights of the normal population were significantly lower in all patients with a prepubertal diagnosis of CD (-0.8±0.9) compared with the other patient groups (-0.1±0.8, P<0.001). Prepubertal onset of CD emerged as a risk factor for reduced final height in patients with prepubertal CD. No difference for final height was found between patients with ulcerative or unclassified IBD diagnosed at prepubertal, pubertal or adult age. CONCLUSION Prepubertal onset of CD is a risk for lower final height, independent of the initial disease location and the necessity for surgical interventions.

Early English Text Society.

Latest issue consulted: No. 229 (for 1948), published in 1954.

Vices and virtues, being a soul's confession of its sins with reason's description of the virtues. A middle-English dialogue of about 1200 A.D.

Includes index.

Early English Text Society.

Published for the Early English Text Society by various publishers.

Isidori Hispalensis episcopi Liber differentiarum (II) /

Originally presented as the editor's thesis (doctoral)--Universidad de Salamanca, 1996.

Missale Gothicum : e codice Vaticano Reginensi Latino 317 editum /

Includes bibliographical references (p. 334-348) and indexes.

"The Rockefeller McCormick manuscript and what came of it," a bibliographical record,

Mode of access: Internet.

Early English prose romances : with bibliographical and historical introductions /

Originally issued separately (?) in 1827, with cover-title: Early prose romances. A collection of ancient English fictions.

A select library of the Nicene and post-Nicene fathers of the Christian church.

Mode of access: Internet.

Our Christian classics : readings from the best divines with notices biographical and critical /

Mode of access: Internet.

The China Christian year book

Mode of access: Internet.

The Plutarch’s Motive of "Descensus Animae" in "Nag Hammadi and the Corpus Hermeticum"

Al evaluar los contactos de Plutarco con otras culturas contemporáneas, los investigadores todavía no han llegado a un consenso acerca de la relación entre el queronense y la literatura cristiano-primitiva. Un buen ejemplo de esto aparece al atender al motivo de la creación del alma humana. La intención de las próximas páginas es, tras un análisis de los textos plutarqueos, atender a estos posibles contactos con NHC, los heresiólogos y el Corpus Hermeticum a fin de dilucidar sus similitudes y diferencias.

Eclipses, razón y superstición en las vidas de Nicias y Dión de Plutarco

A partir de un abordaje retórico-literario, nuestro objetivo es indagar las representaciones discursivas de los elementos supersticiosos en la biografía de Nicias y en la de Dión. Tomaremos como ejemplo el eclipse de luna narrado en Nicias 23 y reiterado en Dión 24, para demostrar que mediante la repetición del ejemplo en dos contextos distintos Plutarco nos invita a reflexionar sobre la superstición de un modo más atractivo que la mera exposición teórica de doctrinas filosóficas.

La música en el desarrollo de la espiritualidad y la religiosidad. Una aproximación al Cristianismo y al Budismo

La música puede afectar al individuo en todos sus niveles –físico, mental y espiritual–. El presente artículo se centra en el papel que ésta desempeña en el desarrollo de la vida espiritual y trascendental. Para ello, realizaremos un repaso histórico de su evolución estética y social, abordaremos dicho fenómeno a nivel fisiológico y presentaremos sus aplicaciones clínicas y sociales. Seguidamente y a modo de ejemplo de las concepciones de pensamiento occidental y oriental, trataremos la forma en que el cristianismo y el budismo conciben la música dentro de su doctrina. Finalizaremos con algunas reflexiones sobre el tema.