Persiles y Sigismunda. Edición publicada por Rodolfo Schevill y Adolfo Bonilla.

Mode of access: Internet.

El "Diario" de Rodolfo Walsh o la impotencia de la escritura

El presente trabajo se propone poner de relieve un rastreo de la experiencia de la imposibilidad de escribir en Ese hombre y otros papeles personales de Rodolfo Walsh, como una forma de exposición de la impotencia. Para ello se detendrá en diversas entradas del "Diario" donde tal impotencia -fundamentalmente ligada a la escritura de la Novela- se manifiesta en sus matices, y ensayará una hipótesis sobre la índole de los mismos a partir de la idea de materia escrituraria, como pura posibilidad, apoyándose en los trabajos de Giorgio Agamben.

Rodolfo Kusch y la constitución de lo popular en la Argentina

De la vasta obra del filósofo argentino Rodolfo Kusch (1922-1979), quién desarrollara diversas líneas de reflexión-investigación, abordaremos sus tesis sobre la constitución de lo popular en la Argentina. Para ello nos detendremos en dos momentos: por un lado, desarrollaremos su peculiar lectura sobre el ciclo político de la independencia y sobre el período de la organización nacional-estatal argentina, centrándonos en su debate con el clásico binomio sarmientino "civilización o barbarie" y subrayando el parentesco de ciertos conceptos de nuestro autor con aportes más recientes del paradigma de la modernidad / colonialidad. En una segunda instancia, nos referiremos a la persistencia de lo indígena en la constitución de lo popular en nuestro país, en diálogo con otras posiciones del pensamiento nacional y latinoamericano, y derivaremos de allí ciertas conclusiones para la investigación en ciencias sociales.

El "Diario" de Rodolfo Walsh o la impotencia de la escritura

El presente trabajo se propone poner de relieve un rastreo de la experiencia de la imposibilidad de escribir en Ese hombre y otros papeles personales de Rodolfo Walsh, como una forma de exposición de la impotencia. Para ello se detendrá en diversas entradas del "Diario" donde tal impotencia -fundamentalmente ligada a la escritura de la Novela- se manifiesta en sus matices, y ensayará una hipótesis sobre la índole de los mismos a partir de la idea de materia escrituraria, como pura posibilidad, apoyándose en los trabajos de Giorgio Agamben.

Rodolfo Kusch : Tesis para la descolonización

Rodolfo Kusch (1922-1979) es autor de una obra vasta que aún sigue parcialmente inexplorada. El presente trabajo se propone sistematizar críticamente lo que identificamos como una de sus cuatro grandes líneas de reflexión-investigación, constituida por una serie ?tesis histórico-sociológicas?. Además de recuperar estas tesis apenas abordadas por sus comentaristas, nos propondremos indagar someramente en algunos trazos de su itinerario intelectual, para situar en ciertas coordenadas espacio-temporales y en un determinado campo intelectual y político la producción del autor. Por último, a lo largo de todo el trabajo también nos abocaremos a tender ciertos puentes entre la obra kuscheana y otras teorías críticas, señalando límites, potencialidades, anticipaciones y vigencias de sus aportes para reflexionar sobre las tareas inconclusas de la descolonización en América Latina

Rodolfo Kusch : Tesis para la descolonización

Rodolfo Kusch (1922-1979) es autor de una obra vasta que aún sigue parcialmente inexplorada. El presente trabajo se propone sistematizar críticamente lo que identificamos como una de sus cuatro grandes líneas de reflexión-investigación, constituida por una serie ?tesis histórico-sociológicas?. Además de recuperar estas tesis apenas abordadas por sus comentaristas, nos propondremos indagar someramente en algunos trazos de su itinerario intelectual, para situar en ciertas coordenadas espacio-temporales y en un determinado campo intelectual y político la producción del autor. Por último, a lo largo de todo el trabajo también nos abocaremos a tender ciertos puentes entre la obra kuscheana y otras teorías críticas, señalando límites, potencialidades, anticipaciones y vigencias de sus aportes para reflexionar sobre las tareas inconclusas de la descolonización en América Latina

Rodolfo Kusch : Tesis para la descolonización

Rodolfo Kusch (1922-1979) es autor de una obra vasta que aún sigue parcialmente inexplorada. El presente trabajo se propone sistematizar críticamente lo que identificamos como una de sus cuatro grandes líneas de reflexión-investigación, constituida por una serie ?tesis histórico-sociológicas?. Además de recuperar estas tesis apenas abordadas por sus comentaristas, nos propondremos indagar someramente en algunos trazos de su itinerario intelectual, para situar en ciertas coordenadas espacio-temporales y en un determinado campo intelectual y político la producción del autor. Por último, a lo largo de todo el trabajo también nos abocaremos a tender ciertos puentes entre la obra kuscheana y otras teorías críticas, señalando límites, potencialidades, anticipaciones y vigencias de sus aportes para reflexionar sobre las tareas inconclusas de la descolonización en América Latina

“La hoz y el machete. La internacional Comunista y Centroamérica". (Rodolfo Cerdas Cruz)

IntroducciónHace aproximadamente una década Rodolfo Cerdas Cruz presentó una tesis de doctorado en Francia titulada "Strategie et Tactique de l'Internationale Communiste en Amérique Lanite" de la cual La hoz y el Machete, presumiblemente, es su versión española en forma de libro; acutalizada a juzgar por algunas de las referencias bibliográficas...

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5–89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.

Career adaptability and career entrenchment

Career adaptability constitutes a resource that can help employees to effectively manage career changes and challenges. The goal of this study was to investigate the relationship between the two higher-order constructs of career adaptability and career entrenchment (i.e., the perceived inability and/or unwillingness to pursue new career opportunities), as well as relationships among the dimensions of career adaptability and career entrenchment. We hypothesized a negative relationship between overall career adaptability and career entrenchment, and more differentiated associations among their dimensions. Data for this study came from 404 employees in Brazil. Results of structural equation modeling showed that overall career adaptability weakly negatively predicted overall career entrenchment (standardized effect = − .13), after controlling for age, gender, education, and job tenure. More differentiated findings emerged at the dimension level. Future research should examine the mechanisms and boundary conditions of the relationship between career adaptability and career entrenchment.

Ebselen is a potent non-competitive inhibitor of extracellular nucleoside diphosphokinase

Nucleoside di- and triphosphates and adenosine regulate several components of the mucocilairy clearance process (MCC) that protects the lung against infections, via activation of epithelial purinergic receptors. However, assessing the contribution of individual nucleotides to MCC functions remains difficult due to the complexity of the mechanisms of nucleotide release and metabolism. Enzymatic activities involved in the metabolism of extracellular nucleotides include ecto-ATPases and secreted nucleoside diphosphokinase (NDPK) and adenyl kinase, but potent and selective inhibitors of these activities are sparse. In the present study, we discovered that ebselen markedly reduced NDPK activity while having negligible effect on ecto-ATPase and adenyl kinase activities. Addition of radiotracer gamma P-32]ATP to human bronchial epithelial (HBE) cells resulted in rapid and robust accumulation of P-32]-inorganic phosphate ((32)Pi). Inclusion of UDP in the incubation medium resulted in conversion of gamma P-32]ATP to P-32]UTP, while inclusion of AMP resulted in conversion of gamma P-32]ATP to P-32]ADP. Ebselen markedly reduced P-32]UTP formation but displayed negligible effect on (32)Pi or P-32]ADP accumulations. Incubation of HBE cells with unlabeled UTP and ADP resulted in robust ebselen-sensitive formation of ATP (IC50=6.9 +/- 2 mu M). This NDPK activity was largely recovered in HBE cell secretions and supernatants from lung epithelial A549 cells. Kinetic analysis of NDPK activity indicated that ebselen reduced the V-max of the reaction (K-i=7.6 +/- 3 mu M), having negligible effect on KM values. Our study demonstrates that ebselen is a potent noncompetitive inhibitor of extracellular NDPK.

Averting biodiversity collapse in tropical forest protected areas

The rapid disruption of tropical forests probably imperils global biodiversity more than any other contemporary phenomenon(1-3). With deforestation advancing quickly, protected areas are increasingly becoming final refuges for threatened species and natural ecosystem processes. However, many protected areas in the tropics are themselves vulnerable to human encroachment and other environmental stresses(4-9). As pressures mount, it is vital to know whether existing reserves can sustain their biodiversity. A critical constraint in addressing this question has been that data describing a broad array of biodiversity groups have been unavailable for a sufficiently large and representative sample of reserves. Here we present a uniquely comprehensive data set on changes over the past 20 to 30 years in 31 functional groups of species and 21 potential drivers of environmental change, for 60 protected areas stratified across the world's major tropical regions. Our analysis reveals great variation in reserve `health': about half of all reserves have been effective or performed passably, but the rest are experiencing an erosion of biodiversity that is often alarmingly widespread taxonomically and functionally. Habitat disruption, hunting and forest-product exploitation were the strongest predictors of declining reserve health. Crucially, environmental changes immediately outside reserves seemed nearly as important as those inside in determining their ecological fate, with changes inside reserves strongly mirroring those occurring around them. These findings suggest that tropical protected areas are often intimately linked ecologically to their surrounding habitats, and that a failure to stem broad-scale loss and degradation of such habitats could sharply increase the likelihood of serious biodiversity declines.

The adenylyl cyclase Rv2212 modifies the proteome and infectivity of Mycobacterium bovis BCG

All organisms have the capacity to sense and respond to environmental changes. These signals often involve the use of second messengers such as cyclic adenosine monophosphate (cAMP). This second messenger is widely distributed among organisms and coordinates gene expression related with pathogenesis, virulence, and environmental adaptation. Genomic analysis in Mycobacterium tuberculosis has identified 16 adenylyl cyclases (AC) and one phosphodiesterase, which produce and degrade cAMP, respectively. To date, ten AC have been biochemically characterized and only one (Rv0386) has been found to be important during murine infection with M. tuberculosis. Here, we investigated the impact of hsp60-driven Rv2212 gene expression in Mycobacterium bovis Bacillus Calmette-Guerin (BCG) during growth in vitro, and during macrophage and mice infection. We found that hsp60-driven expression of Rv2212 resulted in an increased capacity of replication in murine macrophages but an attenuated phenotype in lungs and spleen when administered intravenously in mice. Furthermore, this strain displayed an altered proteome mainly affecting proteins associated with stress conditions (bfrB, groEL-2, DnaK) that could contribute to the attenuated phenotype observed in mice.

An estimate of the number of tropical tree species

The high species richness of tropical forests has long been recognized, yet there remains substantial uncertainty regarding the actual number of tropical tree species. Using a pantropical tree inventory database from closed canopy forests, consisting of 657,630 trees belonging to 11,371 species, we use a fitted value of Fisher's alpha and an approximate pantropical stem total to estimate the minimum number of tropical forest tree species to fall between similar to 40,000 and similar to 53,000, i.e., at the high end of previous estimates. Contrary to common assumption, the Indo-Pacific region was found to be as species-rich as the Neotropics, with both regions having a minimum of similar to 19,000-25,000 tree species. Continental Africa is relatively depauperate with a minimum of similar to 4,500-6,000 tree species. Very few species are shared among the African, American, and the Indo-Pacific regions. We provide a methodological framework for estimating species richness in trees that may help refine species richness estimates of tree-dependent taxa.

Regional research priorities in brain and nervous system disorders

The characteristics of neurological, psychiatric, developmental and substance-use disorders in low-and middle-income countries are unique and the burden that they have will be different from country to country. Many of the differences are explained by the wide variation in population demographics and size, poverty, conflict, culture, land area and quality, and genetics. Neurological, psychiatric, developmental and substance-use disorders that result from, or are worsened by, a lack of adequate nutrition and infectious disease still afflict much of sub-Saharan Africa, although disorders related to increasing longevity, such as stroke, are on the rise. In the Middle East and North Africa, major depressive disorders and post-traumatic stress disorder are a primary concern because of the conflict-ridden environment. Consanguinity is a serious concern that leads to the high prevalence of recessive disorders in the Middle East and North Africa and possibly other regions. The burden of these disorders in Latin American and Asian countries largely surrounds stroke and vascular disease, dementia and lifestyle factors that are influenced by genetics. Although much knowledge has been gained over the past 10 years, the epidemiology of the conditions in low-and middle-income countries still needs more research. Prevention and treatments could be better informed with more longitudinal studies of risk factors. Challenges and opportunities for ameliorating nervous-system disorders can benefit from both local and regional research collaborations. The lack of resources and infrastructure for health-care and related research, both in terms of personnel and equipment, along with the stigma associated with the physical or behavioural manifestations of some disorders have hampered progress in understanding the disease burden and improving brain health. Individual countries, and regions within countries, have specific needs in terms of research priorities.