Statement of vessels and merchandise passed downward through the Welland Canal at Port Colborne during the year 1859

Statement of vessels and merchandise passed downward through the Welland Canal at Port Colborne during the year 1859 showing nationalities of ports of clearance and discharge, June 29, 1862.

Statement of vessels and merchandise passed downward through the Welland Canal at Port Colborne during the year 1860

Statement of vessels and merchandise passed downward through the Welland Canal at Port Colborne during the year 1860 showing nationalities of ports of clearance and discharge, Jan. 29, 1862.

Statement of vessels and merchandise passed downward through the Welland Canal at Port Colborne during the year 1861

Statement of vessels and merchandise passed downward through the Welland Canal at Port Colborne during the year 1861 showing nationalities of ports of clearance and discharge. This is torn in a number of places and stained. This does not affect the text, Jan. 30, 1862.

Statement showing the totals of the quantity of each class of articles transported on the Welland Canal during the years ending on the 31st of December 1857-1861

Statement showing the totals of the quantity of each class of articles transported on the Welland Canal during the years ending on the 31st of December 1857-1861 and the amount of tolls collected thereon 2 ½ page, hand drawn chart), Dec. 31, 1861.

Statement of the quantity of each article transported on the Welland Canal during the years 1857- 1861 from the Welland Canal Office, Dunnville

Statement of the quantity of each article transported on the Welland Canal during the years 1857- 1861 from the Welland Canal Office, Dunnville. [This is a package containing charts and sections of charts – in total, 26 pieces of hand drawn charts wrapped in a piece of paper], 1862.

Statement from the Sheriff’s Office, Lincoln that there are no writs of execution or extent against Owen Clifford

Statement from the Sheriff’s Office, Lincoln that there are no writs of execution or extent against Owen Clifford. This is signed by Joseph A. Woodruff, March 5, 1869.

Statement of Debentures lodged in the Bank of Upper Canada for Safe Keeping and for Collection the Interest

Statement of Debentures lodged in the Bank of Upper Canada for Safe Keeping and for Collection the Interest on them every 6 months, on the 8th of February and the 8th of August every year (handwritten), 1848, 1850.

Statement of Debentures lodged in the Bank of Upper Canada for Safe Keeping and for Collection the Interest

Statement of Debentures lodged in the Bank of Upper Canada for Safe Keeping and for Collection the Interest on them every 6 months, on the 8th of February and the 8th of August every year (handwritten). [This is a more detailed copy of the above item], 1848, 1850.

Statement (1 page, handwritten) received of Captain Robert Wells of the Lincoln Militia

Statement (1 page, handwritten) received of Captain Robert Wells of the Lincoln Militia. The names of his men listed are listed on the page. Dec. 15, 1798.

Screening for adolescent idiopathic scoliosis: an information statement by the scoliosis research society international task force

Background: Routine screening of scoliosis is a controversial subject and screening efforts vary greatly around the world. METHODS: Consensus was sought among an international group of experts (seven spine surgeons and one clinical epidemiologist) using a modified Delphi approach. The consensus achieved was based on careful analysis of a recent critical review of the literature on scoliosis screening, performed using a conceptual framework of analysis focusing on five main dimensions: technical, clinical, program, cost and treatment effectiveness. FINDINGS: A consensus was obtained in all five dimensions of analysis, resulting in 10 statements and recommendations. In summary, there is scientific evidence to support the value of scoliosis screening with respect to technical efficacy, clinical, program and treatment effectiveness, but there insufficient evidence to make a statement with respect to cost effectiveness. Scoliosis screening should be aimed at identifying suspected cases of scoliosis that will be referred for diagnostic evaluation and confirmed, or ruled out, with a clinically significant scoliosis. The scoliometer is currently the best tool available for scoliosis screening and there is moderate evidence to recommend referral with values between 5 degrees and 7 degrees. There is moderate evidence that scoliosis screening allows for detection and referral of patients at an earlier stage of the clinical course, and there is low evidence suggesting that scoliosis patients detected by screening are less likely to need surgery than those who did not have screening. There is strong evidence to support treatment by bracing. INTERPRETATION: This information statement by an expert panel supports scoliosis screening in 4 of the 5 domains studied, using a framework of analysis which includes all of the World Health Organisation criteria for a valid screening procedure.

The Financial Statement Insurance Alternative to Auditor Liability

These articles evaluate using financial statement insurance (FSI) to reduce the frequency and magnitude of audit failure. The FSI concept was pioneered by Josh Ronen, NYU Accounting Professor, who has modeled its economic aspects. My paper examines FSI’s efficacy from policy and legal perspectives. I conclude that while the model is not perfect, it promises considerable advantages over the current model. While some of the existing system’s imperfections are sustained or reappear in different guises, none of the existing imperfections appears to be aggravated and the rest likely are mitigated significantly. So I prescribe a framework to permit companies, on an experimental-basis and with investor approval, to use FSI as an optional alternative to financial statement auditing backed by auditor liability.

Research through DESIGN through research - a problem statement and a conceptual sketch

This paper re-addresses the issue of a lacking genuine design research paradigm. It tries to sketch an operational model of such a paradigm, based upon a generic design process model, which is derived from basic notions of evolution and learning in different domains of knowing (and turns out to be not very different from existing ones). It does not abandon the scientific paradigm but concludes that the latter has to be embedded into / subordinated under a design paradigm.

Inmunoterapia en pacientes con cáncer de pulmón de células no pequeñas versus terapia convencional. Revisión sistemática

RESUMEN Antecedentes y Justificación: El cáncer de pulmón es la principal causa de muerte relacionada con Cáncer en el mundo. El cáncer pulmonar de células no pequeñas (Non-Small-cell lung cancer NSCLC) representa el 85% de todos los cánceres de pulmón y en un 40% es diagnosticado tardíamente y con los tratamientos disponibles actualmente (cirugía, radioterapia y quimioterapia) presenta una supervivencia a 5 años entre el 10 y el 15%. En los últimos años han surgido nuevos tratamientos basados en la inmunoterapia que prometen mejorar la supervivencia de estos pacientes. Objetivo: Determinar la eficacia de la inmunoterapia en el tratamiento del cáncer de pulmón de células no pequeñas (NSCLC) con el fin de integrar la información disponible para su posterior uso en la clínica. Metodología: Se realizó búsqueda exhaustiva de la literatura disponible del 1 de Enero de 2003 al 31 de Diciembre de 2013. Se examinaron las siguientes bases de datos: Pubmed, Scielo, Medline, Lilacs, EMBASE, Bandolier, peDRO y Cochrane. Se utilizaron los términos MeSH de búsqueda: immunotherapy, NSCLC, clinical trials. Resultados: de 163 referencias identificadas en las bases de datos, 12 fueron seleccionadas para la revisión. Se identificaron 11 estrategias inmunoterapéuticas que fueron complementarias al uso de quimioterapia, radioterapia o ambas. No se encontró diferencia significativa entre la supervivencia global de los grupos de intervención y controles con excepción de 1 artículo. La mayoría de efectos secundarios fueron de leves a moderados y no hubo diferencias significativas entre los grupos. Discusión: no se evidenció un aumento significativo de la supervivencia global con la utilización de inmunoterapias, a excepción de la que emplea células asesinas inducidas por citocinas junto a células dendríticas. Sin embargo es necesario esperar resultados de estudios fase III en curso.