Retinal pigment epithelium tears after intravitreal injection of ranibizumab for predominantly classic neovascular membranes secondary to age-related macular degeneration.

PURPOSE: Retinal pigment epithelium (RPE) tear is an extremely rare complication in patients with classic neovascular membranes without RPE detachment. We evaluate their incidence and functional outcome following treatment with intravitreal ranibizumab. METHODS: Observational study of 72 consecutive patients (74 eyes) treated at Jules Gonin University Eye Hospital, Lausanne, with intravitreal ranibizumab 0.5 mg for classic choroidal neovascularization (CNV) between March 2006 and February 2008. Best-corrected visual acuity (BCVA), fundus examination and optical coherence tomography were recorded monthly; fluorescein angiography was performed at baseline and repeated at least every 3 months. RESULTS: RPE tears occurred in four (5.4%) eyes temporal to the fovea, after a mean of four injections (range 3-6). Mean baseline BCVA was 0.25 decimal equivalent (logMAR 0.67) and improved despite the RPE tear to 0.6 decimal equivalent (logMAR 0.22). CONCLUSION: RPE tears following intravitreal ranibizumab injections for classic CNV can occur in about 5% of patients, even in the absence of baseline RPE detachment. Nevertheless, vision may improve provided the fovea is not involved.

Statuts, articles, ordonnances et règlements des jurés et Anciens bacheliers et maîtres de la Communauté des Savetiers... de Paris, vérifiés en Parlement le vingtième mars 1659

[Acte. 1659-03-20]

Extraits de différents auteurs ecclésiastiques, notamment de saint Isidore. Plusieurs articles se rapportent à la grammaire.

Acquis le 15 mai 1830 d'Armans-Alexis Monteil parmi 80 ouvrages pour le prix global de 2400 francs; cf. B.n.F., département des Manuscrits, registre des acquisitions 1828-1833, n° 65/15 "Varia doctrina Xe s".