Cloona Oasis Centre - Davette Martin

The organisation helps those with mental ill health and those suffering addiction. This is their second community-pharmacy project. The first focussed on men and this project will move on to work with women. Women who have been referred to Cloona Oasis have been through hardship. The Pharmacist will work with them to develop their confidence, explain their medication and break down barriers so that they can access other services.

Martin Heidegger

Nota biogràfica sobre el filòsof Martin Heidegger on es fa, per una banda, un breu repàs dels principals fets de la seva vida com a filòsof i, per una altra banda, un breu repàs de la seva obra

Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.

Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred mouse strains differ in susceptibility to anti-GBM antibody-induced and spontaneous lupus nephritis. This study sought to clarify the genetic and molecular factors that maybe responsible for enhanced immune-mediated renal disease in these models. When the kidneys of 3 mouse strains sensitive to anti-GBM antibody-induced nephritis were compared with those of 2 control strains using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene family,which encodes serine esterases. Mouse strains that upregulated renal and urinary kallikreins exhibited less evidence of disease. Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced nephritis. In addition, nephritis-sensitive mouse strains had kallikrein haplotypes that were distinct from those of control strains, including several regulatory polymorphisms,some of which were associated with functional consequences. Indeed, increased susceptibility to anti-GBM antibody-induced nephritis and spontaneous lupus nephritis was achieved by breeding mice with a genetic interval harboring the kallikrein genes onto a disease-resistant background. Finally, both human SLE and spontaneous lupus nephritis were found to be associated with kallikrein genes, particularly KLK1 and the KLK3 promoter, when DNA SNPs from independent cohorts of SLE patients and controls were compared. Collectively, these studies suggest that kallikreins are protective disease-associated genes in anti-GBM antibody-induced nephritis and lupus.

Noyon, cathédrale [Notre-Dame] vue de la rue St Martin [dégâts dus à la guerre] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57125

Ypres, les halles [i. e. la cathédrale Saint-Martin, ruines] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57808

Ypres, les halles [i. e. la cathédrale Saint-Martin, ruines] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57807

Ypres, les halles [i. e. la cathédrale Saint-Martin, ruines] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57806

28-01-20, Ypres [la cathédrale Saint-Martin en ruines] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57797