Migraine With Aura and Migraine Without Aura Are Not Distinct Entities: Further Evidence From a Large Dutch Population Study

It is often debated whether migraine with aura (MA) and migraine without aura (MO) are etiologically distinct disorders. A previous study using latent class analysis (LCA) in Australian twins showed no evidence for separate subtypes of MO and MA. The aim of the present study was to replicate these results in a population of Dutch twins and their parents, siblings and partners (N = 10,144). Latent class analysis of International Headache Society (IHS)-based migraine symptoms resulted in the identification of 4 classes: a class of unaffected subjects (class 0), a mild form of nonmigrainous headache (class 1), a moderately severe type of migraine (class 2), typically without neurological symptoms or aura (8% reporting aura symptoms), and a severe type of migraine (class 3), typically with neurological symptoms, and aura symptoms in approximately half of the cases. Given the overlap of neurological symptoms and nonmutual exclusivity of aura symptoms, these results do not support the MO and MA subtypes as being etiologically distinct. The heritability in female twins of migraine based on LCA classification was estimated at .50 (95% confidence intervals [0CI} .27 -.59), similar to IHS-based migraine diagnosis (h(2) = .49, 95% Cl .19-.57). However, using a dichotomous classification (affected-unaffected) decreased heritability for the IHS-based classification (h(2) = .33, 95% Cl .00-.60), but not the LCA-based classification (h(2) = .51, 95% Cl. 23-.61). Importantly, use of the LCA-based classification increased the number of subjects classified as affected. The heritability of the screening question was similar to more detailed LCA and IHS classifications, suggesting that the screening procedure is an important determining factor in genetic studies of migraine.

Spatio-temporal imaging of corticaldesynchronization in migraine visual aura:a magnetoencephalography case study

Objective.-To determine cortical oscillatory changes involved in migraine visual aura using magnetoencephalography (MEG). Background.-Visual aura in the form of scintillating scotoma precedes migraine in many cases. The involvement of cortical spreading depression within striate and extra-striate cortical areas is implicated in the generation of the disturbance, but the details of its progression, the effects on cortical oscillations, and the mechanisms of aura generation are unclear. Methods.-We used MEG to directly image changes in cortical oscillatory power during an episode of scintillating scotoma in a patient who experiences aura without subsequent migraine headache. Using the synthetic aperture magnetometry method of MEG source imaging, focal changes in cortical oscillatory power were observed over a 20-minute period and visualized in coregistration with the patient's magnetic resonance image. Results.-Alpha band desynchronization in both the left extra-striate and temporal cortex persisted for the duration of reported visual disturbance, terminating abruptly upon disappearance of scintillations. Gamma frequency desynchronization in the left temporal lobe continued for 8 to 10 minutes following the reported end of aura. Conclusions.-Observations implicate the extra-striate and temporal cortex in migraine visual aura and suggest involvement of alpha desynchronization in generation of phosphenes and gamma desynchronization in sustained inhibition of visual function.

Donde esten mis hijos alli que me entierren. the migration history of Aura Lila Callejas

"Adonde esten mis hijos alli que me entierren," presents the migration history of my great-aunt Aura Lila Callejas. This work utilizes the oral history method to examine one woman's migration experience in an attempt to identify various theoretical issues. Aura Lila's immigration experience sheds light on a number of different issues, including the reasons why people migrate and how they adapt to an entirely new and often frightening set of circumstances in the country of arrival. The oral history method has proven useful in presenting some of the ways in which structural factors combine with personal motivations to provide the impetus for Aura Lila's journey of international migration. My work with Aura Lila has also served to highlight some of the existing gaps in the current literature regarding Nicaraguans in the United States and the importance of the family within the overall process of migration. Finally, this work explores the nature of the relationship between the researcher and subject within the ethnographic process. While much of Aura Lila's story remains unique and specific to her family's history, her narrative can be related to the growing body of literature focusing on women's life histories.

El vaciado del natural vida, muerte y aura en la escultura

Como término artístico, denominamos vaciado del natural al procedimiento por medio del cual se obtiene, a través de un proceso de moldes, una copia tridimensional precisa en cuanto a volumen y a texturas de cualquier elemento de la naturaleza, sea vivo o inerte, orgánico o inorgánico. El término también es utilizado para definir el producto resultante de la práctica de este procedimiento. Si aplicamos esta definición en sentido estricto, no podría considerarse vaciado del natural la reproducción por medio de moldes de elementos manufacturados por el hombre. No obstante, en la reproducción de elementos artificiales o manufacturados, se considera aplicable el término vaciado del natural a la reproducción de objetos que han sido creados para una función distinta de la artística que se pretende con su vaciado, como pueda ser una silla o una guitarra. Este procedimiento se ha aplicado habitualmente en la creación escultórica y a este ámbito se dirige el enfoque de la investigación. No obstante, por diversas causas, el procedimiento ha sido muy útil a otras áreas de conocimiento como la arqueología o la medicina y la evolución de su aplicación ha estado intrínsecamente unida a los creadores plásticos con los que se ha producido una estrecha colaboración. Esta se ha producido en las dos direcciones, acudiendo las ciencias que así lo requerían a los artistas como conocedores de la técnica y los procesos e incorporando los artistas a su trabajo las innovaciones desarrolladas por otras áreas e inspirándose en sus resultados. Esta estrecha colaboración hace que en la investigación se traten aspectos que atañen a otras áreas de conocimiento y se analicen sus conexiones con el arte. El objetivo de la presente investigación es desarrollar un estudio desde los posibles orígenes de este procedimiento y analizar su utilización a lo largo de la historia en el entorno socio-cultural de la civilización occidental. Para ello se acude a la documentación escrita que revela y analiza la utilización del vaciado del natural y se investigan las pruebas físicas que la demuestran (moldes, positivos, huellas del natural)...

El libro maligno: Aura e Inés

Se explora la figura del lector y la naturaleza envolvente del libro que lo seduce.

Catalogue des tableaux, aquarelles, dessins, bronzes, etc. offerts par divers artistes à Henry Monnier dont la vente publique aura lieu Hôtel Druot ... 20 mai 1875 ...

Mode of access: Internet.

Migraine Equivalents In Childhood.

Migraine equivalents are a group of periodic and paroxysmal neurologic diseases. Because headache is not a prominent symptom, the diagnosis might be challenging. The objective of the study was to evaluate the frequency and outcome of migraine equivalents. This was a retrospective study. We included benign paroxysmal torticollis of infancy, benign paroxysmal vertigo of infancy, abdominal migraine, cyclic vomiting, aura without migraine, and confusional migraine. We evaluated the frequency of events, treatment, and outcome. Out of 674 children with headache, 38 (5.6%) presented with migraine equivalents. Twenty-one were boys and the mean age was 6.1 years. Fifteen had abdominal migraine, 12 benign paroxysmal vertigo, 5 confusional migraine, 3 aura without migraine, 2 paroxysmal torticollis, and 1 cyclic vomiting. Prophylactic treatment was introduced in 23 patients; 4 lost follow-up and 19 had significant improvement. We conclude that the correct diagnosis of migraine equivalents enables an effective treatment with an excellent outcome.

Novos registros e potencial epidemiológico de algumas espécies de mosquitos (Diptera, Culicidae), no Estado do Rio Grande do Sul

INTRODUÇÃO: A vigilância entomológica tem se mostrado uma importante estratégia de monitoramento da fauna de culicídeos com vistas a predizer o risco de exposição a espécies vetoras de patógenos. Esse trabalho apresenta uma lista de mosquitos identificados pela primeira vez no Rio Grande do Sul e discute o potencial epidemiológico de algumas espécies ocorrentes no Município de Maquiné com registros em outras regiões do Estado. MÉTODOS: Os mosquitos foram coletados com aspirador de Nasci e armadilhas CDC, entre dezembro de 2006 e dezembro de 2008, em área silvestre, rural e urbana do Município de Maquiné. RESULTADOS: Foram verificadas 55 espécies, das quais 22 são registradas pela primeira vez no estado e 10 são potencialmente vetoras do vírus Saint Louis, Oropouche, Aura, Trocara, Ilhéus, Rocio, Una, West Nile e encefalite equina do leste. CONCLUSÕES: Esses dados demonstram a importância da Vigilância Entomológica como ferramenta de informação e ação para a Vigilância em Saúde.

Vascular Endothelial Growth Factor Genetic Polymorphisms and Haplotypes in Women with Migraine

Vascular endothelial growth factor (VEGF) production is regulated by growth factors and inflammatory cytokines, and VEGF plays a role in migraine. We examined for the first time whether three functional polymorphisms in the promoter region of VEGF gene (C(-2578)A, G(-1154A), and G(-634C)) and VEGF haplotypes are associated with migraine. We studied 114 healthy women without migraine and 175 women with migraine (129 without aura, and 46 with aura). We found no differences in the distributions of VEGF genotypes and alleles (p > 0.05). However, the CAC haplotype was more frequent in controls than in migraine patients, and the AGC haplotype was more frequent in patients with migraine with aura than in controls (both p < 0.05). These findings suggest that VEGF haplotypes affect susceptibility to migraine.