Long-circulating bacteriophage as antibacterial agents.

The increased prevalence of multidrug-resistant bacterial pathogens motivated us to attempt to enhance the therapeutic efficacy of bacteriophages. The therapeutic application of phages as antibacterial agents was impeded by several factors: (i) the failure to recognize the relatively narrow host range of phages; (ii) the presence of toxins in crude phage lysates; and (iii) a lack of appreciation for the capacity of mammalian host defense systems, particularly the organs of the reticuloendothelial system, to remove phage particles from the circulatory system. In our studies involving bacteremic mice, the problem of the narrow host range of phage was dealt with by using selected bacterial strains and virulent phage specific for them. Toxin levels were diminished by purifying phage preparations. To reduce phage elimination by the host defense system, we developed a serial-passage technique in mice to select for phage mutants able to remain in the circulatory system for longer periods of time. By this approach we isolated long-circulating mutants of Escherichia coli phage lambda and of Salmonella typhimurium phage P22. We demonstrated that the long-circulating lambda mutants also have greater capability as antibacterial agents than the corresponding parental strain in animals infected with lethal doses of bacteria. Comparison of the parental and mutant lambda capsid proteins revealed that the relevant mutation altered the major phage head protein E. The use of toxin-free, bacteria-specific phage strains, combined with the serial-passage technique, may provide insights for developing phage into therapeutically effective antibacterial agents.

The University of Alicante Library copy of Palmerin d'Oliva (London, 1637): A Bibliographical Description

The purpose of this article is to provide bibliographical information about a copy of the fourth edition of the two parts of Anthony Munday's translation of Palmerin d'Oliva (London, 1637; STC 19160) recently purchased by the University of Alicante Library and not mentioned in the standard bibliographies. The article contains a detailed bibliographical description based on Bowers's principles (1949) and is designed to be useful to scholars by making direct consultation of the copy in most cases unnecessary. The description is preceded by a short introduction to the literary text and its publication in England.

Histoire de Saint Louis; texte original ramene a l'orthographe des chartes precede de notions sur la langue et la grammaire de Joinville et suivi d'un glossaire /

Mode of access: Internet.

[Fragmenta varia graeca]

Collection of Greek texts from 14 distinct manuscripts; 15th century and later.

Greek papyri in the British Museum ...

Note in vol. 6 states that this publication forms "no part of the series 'Greek papyri in the British Museum'." (p.vii) After full consideration it was later decided to regard that title as constituting vol. 6 of this series. (vol.7, p.iii)

Fortællinger for ungdommen.

1. Søfjæren. Jerry Creed -- 2. En gammel herre. Firkløveret.

Observations on the attempted application of pantheistic principles to the theory and historic criticism of the Gospel /

Vol. 2 issued in parts, 1841-1844, continuously paged but without over-all t.p. Each part has separate t.p.

Kritik der christlichen dogmen, nach anleitung des apostolischen symbolums,

Mode of access: Internet.

Religious pamphlets

A collection of miscellaneous pamphlets on religion.

The faith of the ages;

Mode of access: Internet.

A digested index to the Virginia reports, containing all the points argued and determined in the Court of appeals of Virginia, from Washington to [third Leigh] ... inclusive [1790-1832] with a table of the names of the cases reported.

Mode of access: Internet.

Patristique et moyen âge; études d'histoire littéraire et doctrinale.

"Relevé chronologique des publications depuis un siècle": v. 1, p. [239]-260.

The certain hour

"Ballad of the double-soul."--Auctorial induction.--Belhs cavaliers.--Balthazar's daughter.--Judith's creed.--Concerning Corinna.--Olivia's pottage.--A brown woman.--Pro Honoria.--The irresistible Ogle.--A princess of Grub street.--The lady of all our dreams.--"Ballad of plagiary."

Lord Milner's work in South Africa : from its commencement in 1897 to the peace of Vereeniging in 1902 containing hitherto unpublished information /

"First edition, November 1906. Reprinted before publication."